Navigation Links
New optogenetic tool for controlling neuronal signalling by blue light
Date:7/10/2014

Institute for Basic Science (IBS), the main organization of the International Science and Business Belt project in South Korea, has announced that a group of researchers, led by professor Won Do Heo, have developed a new technology in the field of optogenetics that can remotely control specific receptors by light. They have named this new technology "OptoTrk" and it has succeeded with neuronal differentiation inducement.

The most significant feature of OptoTrk technology is that it requires only light to activate neuronal functions without the need of other substances. The receptors are activated when exposed to blue light, and then induce both neuronal growth and differentiation by upregulating downstream cell signalling.

"We are now conducting neuroscience research on several mouse models using our OptoTrk technology," says professor Won Do Heo, who led the research. "This newly developed technology will play a ground-breaking role in investigating the functions of neurons in the brain, specifically those functions in the most complicated of neural networks, which existing technologies have limitations exploring."

Before the development of this new technology, natural ligands or agonists were widely used as tools to specifically control receptor activity. However, they did not allow spatiotemporal control, and so required a time period to bind with the receptor. Therefore, there were limits to understanding the dynamic nature of intracellular signalling networks. To address these limitations, the researchers developed this new technology using optogenetics. Recently optogenetics is attracting attention from many, various fields in the biological sciences. This study applies light-sensitive proteins - found in microorganisms and plants - to human (and/or animal) cells and can manipulate several cell functions.

"We have found that optoTrk can be regulated by simply switching light on and off," says professor Won Do Heo. "We were able to control the functional duration of down-stream signalling by adjusting the frequency of blue-light illumination."

Professor Won Do Heo added that he plans to publish an additional paper related to source technology in another renowned journal by the end of June. This will bring the Professor's number of published research outcomes related to the study of optogenetics to a total of 3 in the last two months. These publications include the paper regarding "Light-Activated Reversible Inhibition by Assembled Trap (LARIAT)". This paper on LARIAT was published in May in the prominent science journal, Nature Method, in the field of biochemistry.


'/>"/>

Contact: Hanbin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science
Source:Eurekalert

Related biology news :

1. Optogenetic toolkit goes multicolor
2. EUREKA grant to fund development of new optogenetic technique for mapping neural networks at UMMS
3. Oxfords Gero Miesenböck is awarded The Brain Prize 2013 for his pioneering work on optogenetics
4. Zülch Prize 2012 for founders of optogenetics
5. Controlling contamination in open algae ponds for biofuels
6. LSTM researchers identify the complex mechanisms controlling changes in snake venom
7. Chemists design molecules for controlling bacterial behavior
8. Controlling brain waves to improve vision
9. Characterization of stink bug saliva proteins opens door to controlling pests
10. Controlling parasitic worms with genetic selection
11. Oregon scientists offer new insights on controlling nanoparticle stability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2017)... SAN ANTONIO , Feb. 3, 2017  Texas Biomedical ... Dr. Larry Schlesinger as the Institute,s ... of Texas Biomed effective May 31, 2017. He is currently ... and Director of the Center for Microbial Interface Biology at ... Dr. Schlesinger as the new President and CEO of Texas ...
(Date:2/1/2017)... IDTechEx Research, a leading provider of independent market research, business ... new report, Sensors for Robotics: Technologies, Markets and Forecasts 2017-2027 ... ... Revenues of ... for Robotics: Technologies, Markets and Forecasts 2017-2027: Machine vision, force sensing ...
(Date:1/25/2017)... The Elements of Enterprise Information Security ... of a comprehensive set of business processes and ... identities and providing a secured and documented access ... number of programs opted by enterprises to maintain ... processes and changing policies. However, there are some ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... REDWOOD CITY, Calif. , Feb. 27, 2017 ... specialty pharmaceutical company focused on the development and ... moderate-to-severe acute pain, announced today the U.S. Food ... New Drug Application (NDA) under section 505(b)(2) for ... for the treatment of patients with moderate-to-severe acute ...
(Date:2/27/2017)... and HAMILTON, Bermuda , ... (NASDAQ: ADXS ) and SELLAS ... focused on developing cancer immunotherapies, today announced that ... a novel cancer immunotherapy agent using Advaxis, proprietary ... patented WT1 targeted heteroclitic peptide antigen mixture (galinpepimut-S). ...
(Date:2/27/2017)... Iowa (PRWEB) , ... February 27, 2017 , ... In ... following the advice of his grandfather, “Hire for attitude. Train for skill.” , In ... University star linebacker Jevohn Miller as a salesman. Zamzow is hoping to replicate the ...
(Date:2/26/2017)... ... 26, 2017 , ... Rob Lowe is a well recognized television personality, so ... focuses on issues that are important to the American public and important to society ... been a hot topic around the world for a few years. , The climate ...
Breaking Biology Technology: