Navigation Links
New opportunities for covalent drugs published by Avila scientists
Date:4/1/2011

description of progress in the design of targeted covalent drugs with a focus on the Avila strategy is discussed.

  • Several rationally designed, targeted covalent inhibitors have recently advanced in clinical development (neratinib, afatinib, PCI-32765 and the Avlia clinical candidate, AVL-292).

  • New publications have reported on targeted covalent inhibitors to diverse drug targets where each demonstrates high specificity of covalent bond formation to its respective target.

  • The pharmacological advantages of covalent drugs are discussed including the potential to address the problem of drug-resistance mutations that often arise in cancer and in infectious diseases.

    Based on this review article, it is apparent that structural bioinformatics approaches, coupled with structure-based drug design, may enable the engineering of highly selective covalent drugs and a resurgence of interest in this important class of therapeutics.


    '/>"/>


  • Contact: Kathryn Morris
    kathryn@theyatesnetwork.com
    845-635-9828
    Yates Public Relations
    Source:Eurekalert

    Page: 1 2

    Related biology news :

    1. IEEE-USA workshop to explore the challenges and opportunities of electric vehicle technology
    2. New oyster farming technique increases productivity, offers entrepreneurial opportunities
    3. IBIA Statement Regarding the Release of the National Research Council Report - Biometric Recognition: Challenges and Opportunities
    4. Behind the secrets of silk lie high-tech opportunities
    5. New book describes career opportunities in clinical research and how to qualify for them
    6. Conference to discuss sensing technology developments and opportunities
    7. Male antelopes trick females into extra sex opportunities
    8. George Daley to discuss challenges and opportunities facing stem cell scientists
    9. Synthetic biology offers new opportunities for interdisciplinary collaboration
    10. NIGMS invests in scientific Grand Opportunities with Recovery Act funds
    11. Frost & Sullivan Looks at Biometrics Advancement in Civil Security: Exploring Opportunities for Today and Beyond
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:7/28/2014)... The genome of Solanum pennellii , a wild ... an international group of researchers including the labs headed ... UC Davis Department of Plant Biology. The new genome ... , The work, published July 27 in the journal ... and colleagues at Aachen University in Germany. The UC ...
    (Date:7/28/2014)... New research has identified areas of the Earth that ... climate change. , Europe is particularly vulnerable, as it ... four per cent, of any continent in ,refugia, ... natural environmental conditions remain relatively constant during times of ... Europe are mostly in Scandinavia and Scotland. , ...
    (Date:7/28/2014)... YORK CITY (July 28, 2014)The Brain & Behavior ... annual Klerman and Freedman Prizes, recognizing exceptional clinical ... been supported by NARSAD Young Investigator Grants. The ... ideas in neurobiological and psychosocial research for the ... illnesses that affect one in four people. , ...
    Breaking Biology News(10 mins):Study finds Europe's habitat and wildlife is vulnerable to climate change 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 4
    ... easy task to compare the environmental effects of battery ... The degree to which manufacture, usage and disposal of ... are detrimental to the environment is not exactly known. ... scientists have made a detailed life cycle assessment (LCA) ...
    ... world-wide collaboration of researchers has identified the first-ever genetic risk ... looked at the genetic data of more than 50,000 people, ... and they hope their research will open the door for ... that patients with a particular DNA variant on Chromosome 8 ...
    ... bigger hazard to the environment specifically to creatures that ... research from North Carolina State University toxicologists. In a ... One, the NC State researchers show that water fleas ... in agriculture as fertilizers and convert those chemicals into ...
    Cached Biology News:'Greener' than expected 2'Greener' than expected 3First genetic link to common migraine exposed 2First genetic link to common migraine exposed 3Fertilizer chemicals linked to animal developmental woes 2
    (Date:7/28/2014)... DALLAS , July 28, 2014 /PRNewswire/ ... research report  "Microbial Identification Market by Products (Consumables, Instruments, ... & Beverages), End User (Detection, Characterization) - ... global Microbial Identification Market is estimated at ... to reach $1,194.1 Million by 2019, growing ...
    (Date:7/28/2014)... Boston, MA (PRWEB) July 28, 2014 ... with two researchers to further develop potential treatments for ... brain tumor, in combination with their patented vaccine platform, ... and Duke University, are based on the work of ... of Neurosurgery at The Preston Robert Tisch Brain Tumor ...
    (Date:7/28/2014)... Appistry, Inc. , a leading provider ... of genomics to next-generation medicine, announced today its judging ... , Two Appistry staff will be joined by ... Genome Resources, and Mr. Neil Miller, director of informatics ... Rounding out the panel are Appistry’s Dr. Richard Mazzarella, ...
    (Date:7/28/2014)... July 28, 2014 The global market ... by 2020, according to a new study by Grand ... rising demand for effective vaccines and drugs in an ... medical needs is expected to drive market demand over ... enhance agricultural productivity via the use of genetically engineered ...
    Breaking Biology Technology:Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
    ... member of Congress announces that a major reason to reform the ... does it like us. , ,Even during an era when America-bashing ... well - and has always done well - much to the ... things is innovation. In fact, the United States is the greatest ...
    ... - TomoTherapy saw its revenues surge by ... according to the first earnings report issued since ... also announced that it has joined a research collaboration with ... lower-cost proton therapy system for cancer treatment. , , First ...
    ... In Part I of this series on ... of Civil Procedure, which require parties to address and ... ("ESI"). Without a plan of attack or a system ... may unnecessarily be placing your company at risk. ...
    Cached Biology Technology:Changes to U.S. patent law must nurture our culture of innovation 2Changes to U.S. patent law must nurture our culture of innovation 3Changes to U.S. patent law must nurture our culture of innovation 4TomoTherapy reports 86% revenue jump, $131M net loss in Q1 2TomoTherapy reports 86% revenue jump, $131M net loss in Q1 3Finding Safe Harbor in a sea of electronic discovery 2Finding Safe Harbor in a sea of electronic discovery 3
    Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
    ...
    ... Upright Freezer Inventory Storage Racks ... configurations available to fit all makes ... refrigerators. Made of high quality ... 3" high fiberboard, stainless steel or ...
    Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
    Biology Products: