Navigation Links
New neuroimaging analysis technique identifies impact of Alzheimer's disease gene in healthy brains
Date:11/17/2009

Amsterdam, November 17, 2009 Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer's Disease.

Investigators used automated neuroimaging analysis techniques to characterize the impact of an AD-risk gene, apolipoprotein E (ApoE4), on gray and white matter in the brains of cognitively healthy elderly from the KU Brain Aging Project.

They found that healthy elderly individuals carrying a risk-allele of the ApoE4 gene had reduced cognitive performance, decreased brain volume in the hippocampus and amygdala (regions important for memory processing), and decreased white matter integrity in limbic regions. These type of brain changes are also found in people with AD. Therefore, brain changes, usually found in AD patients, are also evident in nondemented individuals who have a genetic risk of later developing AD.

Lead investigator, Robyn Honea, DPhil, Research Assistant Professor, University of Kansas School of Medicine, Department of Neurology, Alzheimer's and Memory Group, comments, "It is important to note that findings of imaging phenotypes of risk variants, such as with this gene, have been shown in a number of studies. The unique element of our study is that we used several new neuroimaging analysis techniques. In addition, the individuals in our study have been well-characterized in a clinical setting."


'/>"/>

Contact: Saskia van Wijngaarden
s.van.wijngaarden@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1

Related biology news :

1. First neuroimaging study examining motor execution in children with autism reveals new insights
2. Ginkgo SRMs: Tools for product analysis/quality
3. DNA analysis shows true dispersal of protozoa
4. Interacting protein theory awaits test from new neutron analysis tools
5. Analysis of breast and colon cancer genes finds many areas of differences between tumors
6. Tumor genome analysis unveils new insights into lung cancer
7. Powerful integration of lipid metabolic profiling with gene expression analysis
8. Human clones: New U.N. analysis lays out worlds choices
9. More comprehensive analysis of Klamath River basin needed to aid decision makers
10. Analysis calls for medical device information to better serve patients and doctors
11. Avian origins: new analysis confirms ancient beginnings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, Inc. is pleased ... centers around the U.S. that offer MR Elastography for liver fibrosis staging. ... biopsy for staging liver fibrosis assessment. , “MRE:connect was created in response to ...
(Date:7/20/2017)... ... July 20, 2017 , ... VIC Technology Venture Development™ (VIC™), ... of directors. This addition continues to strengthen and diversify VIC’s board. , "We ... Chairman. “He is a highly accomplished business executive with a broad range of experience ...
(Date:7/20/2017)... San Diego, CA (PRWEB) , ... July 20, 2017 , ... ... to corporate governance at its 27th annual Director of the Year Awards. , The ... Hyatt Regency La Jolla. This annual event celebrates directors who have made significantly ...
(Date:7/18/2017)... ... July 18, 2017 , ... Sourcing custom glass or ... needs and has the capabilities to properly execute your job can take many hours ... is a sourcing portal designed to showcase the company’s capabilities and core custom ...
Breaking Biology Technology: