Navigation Links
New nanoparticles target cardiovascular disease
Date:1/18/2010

CAMBRIDGE, Mass. Researchers at MIT and Harvard Medical School have built targeted nanoparticles that can cling to artery walls and slowly release medicine, an advance that potentially provides an alternative to drug-releasing stents in some patients with cardiovascular disease.

The particles, dubbed "nanoburrs" because they are coated with tiny protein fragments that allow them to stick to target proteins, can be designed to release their drug payload over several days. They are one of the first such particles that can precisely home in on damaged vascular tissue, says Omid Farokhzad, associate professor at Harvard Medical School and an author of a paper describing the nanoparticles in the Jan. 18 issue of the Proceedings of the National Academy of Sciences.

Farokhzad and MIT Institute Professor Robert Langer, also an author of the paper, have previously developed nanoparticles that seek out and destroy tumors.

The nanoburrs are targeted to a specific structure, known as the basement membrane, which lines the arterial walls and is only exposed when those walls are damaged. Therefore, the nanoburrs could be used to deliver drugs to treat atherosclerosis and other inflammatory cardiovascular diseases. In the current study, the team used paclitaxel, a drug that inhibits cell division and helps prevent the growth of scar tissue that can clog arteries.

"This is a very exciting example of nanotechnology and cell targeting in action that I hope will have broad ramifications," says Langer.

The researchers hope the particles could become a complementary approach that can be used with vascular stents, which are the standard of care for most cases of clogged and damaged arteries, or in lieu of stents in areas not well suited to them, such as near a fork in the artery.

The particles, which are spheres 60 nanometers in diameter, consist of three layers: an inner core containing a complex of the drug and a polym
'/>"/>

Contact: Jen Hirsch
jfhirsch@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. First metallic nanoparticles resistant to extreme heat
2. Small nanoparticles bring big improvement to medical imaging
3. Nanoparticles used in common household items caused genetic damage in mice
4. Behavior modification could ease concerns about nanoparticles
5. Knocking nanoparticles off the socks
6. Clemson bioengineer uses nanoparticles to target drugs
7. Therapeutic nanoparticles give new meaning to sugar-coating medicine
8. Carbon nanoparticles toxic to adult fruit flies but benign to young
9. New insights into health and environmental effects of carbon nanoparticles
10. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
11. University of Leicester researchers discover new fluorescent silicon nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... heard of the birds and the bees. But ... are being fertilized. The fertilization process for flowering ... between the male and female reproductive cells. New ... Heidelberg, and Munich, and including Carnegie,s Wolf Frommer, ... the chemical signaling process that guides flowering plant ...
(Date:8/21/2014)... use a previously unknown process for harvesting energy and ... a Penn State University scientist has discovered. The discovery ... plant growth, harvesting energy from the Sun, and understanding ... and other lakes worldwide. A paper describing the discovery ... edition of the journal Science on 21 ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... date of genetic variation among chimpanzees has found that ... central and eastern—is underpinned by significant genetic differences, two ... most different human populations. , In the April ... the University of Chicago, Harvard, the Broad Institute and ...
... cells from being forced to devour themselves, removing one ... researchers at The University of Texas M. D. Anderson ... Cancer Research. , The protein tissue transglutaminase, known by ... at M. D. Anderson and elsewhere to be overexpressed ...
... termites can tell what sort of material their food is ... may lead to improvements in the control of feeding termites. ... and specially designed blocks made of wood and other materials, ... containing the most wood ?even though they could not touch ...
Cached Biology News:Gene study shows three distinct groups of chimpanzees 2Protein found to shield pancreatic cancer cells from self-destruction 2
(Date:8/21/2014)...  BioSpecifics Technologies Corp. (NASDAQ: BSTC ... collagenase-based products marketed as XIAFLEX ® (collagenase ... XIAPEX ® in the EU, today announced ... Phase 2a study of CCH for the potential ... results showed that all three doses of CCH ...
(Date:8/21/2014)... , August 21, 2014 ... http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition of ...  report to their offering.       ... as hormone therapy, is a means of ... produced by the body. This type of ...
(Date:8/21/2014)... Mathematic studies at the Program for Evolutionary Dynamics ... Jeffrey Epstein VI Foundation , have shown that the ... elimination. These aggressive cells are the driver mutations that drive ... of what to look for when examining tumors, comes at ... can be extracted from biopsy, it,s very difficult to know ...
(Date:8/21/2014)... August 21, 2014 Ontotext S4 ... by Ontotext . Now the same enterprise ... of structured and unstructured data is available to start-ups ... of enterprise technology. Organizations that do not have resources ... management can use S4 since there is no need ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... A University of Colorado at Boulder team has developed ... used in nanotechnology devices like computer chips and solar ... Like current methods in the nanoengineering field, one color ... CU-Boulder Assistant Professor Robert McLeod of the electrical, computer ...
... Analytics and Utilization Review Services to Improve Safety ... APS Healthcare, a leading provider of specialty ... information company, have been selected by the New ... state,s Medicaid clinical best practice utilization review program. ...
... Cell Biosciences, Inc., a provider of nanoproteomic ... the launch of the Cell Biosciences CB1000 protein ... of cell signaling proteins. The CB1000 establishes a ... researchers studying signaling pathways in limited samples, such ...
Cached Biology Technology:Novel CU-Boulder technique shrinks size of nanotechnology circuitry 2APS Healthcare and Thomson Reuters to Manage New York State's Medicaid Clinical Best Practices Review Program 2APS Healthcare and Thomson Reuters to Manage New York State's Medicaid Clinical Best Practices Review Program 3APS Healthcare and Thomson Reuters to Manage New York State's Medicaid Clinical Best Practices Review Program 4Cell Biosciences Launches Next-Generation Protein Characterization System 2
Fujifilm Pictro-Color Process for sharp, clear reproduction comparable to silver-halide photography. Photorealistic 400 dpi quality. A4 and A5 output....
... PYREX low form culture flask is designed for culturing ... This flask has a heavy beaded rim to protect ... neck O.D. is 38mm and takes a No. 6.5 ... on a heat source smaller than the base of ...
... FRT-amp-FRT cassette is designed to ... The prokaryotic promoter gb2 driving the gene ... version of the Em7 promoter. It mediates ... Tn5 promoter. A synthetic polyadenylation signal terminates ...
... Application: Pyronin Y is most widely ... to selectively and differentially stain nucleic ... a dichromatic dye solution, Pyronin Y ... stains DNA green. Chem ...
Biology Products: