Navigation Links
New nanoparticles target cardiovascular disease
Date:1/18/2010

CAMBRIDGE, Mass. Researchers at MIT and Harvard Medical School have built targeted nanoparticles that can cling to artery walls and slowly release medicine, an advance that potentially provides an alternative to drug-releasing stents in some patients with cardiovascular disease.

The particles, dubbed "nanoburrs" because they are coated with tiny protein fragments that allow them to stick to target proteins, can be designed to release their drug payload over several days. They are one of the first such particles that can precisely home in on damaged vascular tissue, says Omid Farokhzad, associate professor at Harvard Medical School and an author of a paper describing the nanoparticles in the Jan. 18 issue of the Proceedings of the National Academy of Sciences.

Farokhzad and MIT Institute Professor Robert Langer, also an author of the paper, have previously developed nanoparticles that seek out and destroy tumors.

The nanoburrs are targeted to a specific structure, known as the basement membrane, which lines the arterial walls and is only exposed when those walls are damaged. Therefore, the nanoburrs could be used to deliver drugs to treat atherosclerosis and other inflammatory cardiovascular diseases. In the current study, the team used paclitaxel, a drug that inhibits cell division and helps prevent the growth of scar tissue that can clog arteries.

"This is a very exciting example of nanotechnology and cell targeting in action that I hope will have broad ramifications," says Langer.

The researchers hope the particles could become a complementary approach that can be used with vascular stents, which are the standard of care for most cases of clogged and damaged arteries, or in lieu of stents in areas not well suited to them, such as near a fork in the artery.

The particles, which are spheres 60 nanometers in diameter, consist of three layers: an inner core containing a complex of the drug and a polym
'/>"/>

Contact: Jen Hirsch
jfhirsch@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. First metallic nanoparticles resistant to extreme heat
2. Small nanoparticles bring big improvement to medical imaging
3. Nanoparticles used in common household items caused genetic damage in mice
4. Behavior modification could ease concerns about nanoparticles
5. Knocking nanoparticles off the socks
6. Clemson bioengineer uses nanoparticles to target drugs
7. Therapeutic nanoparticles give new meaning to sugar-coating medicine
8. Carbon nanoparticles toxic to adult fruit flies but benign to young
9. New insights into health and environmental effects of carbon nanoparticles
10. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
11. University of Leicester researchers discover new fluorescent silicon nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... RICHLAND, Wash. A common plant puts out a welcome ... the mat,s molecular mix. , The study published this week ... reveals new targets during the battle between microbe and ... team showed that the humble and oft-studied plant Arabidopsis ... from a pathogen. It,s as if a hostile army were ...
(Date:4/23/2014)... may contribute to early fetal death according to a ... of Children,s Hospital Los Angeles and Ulaanbaatar, Mongolia ... a paper published today in the journal BMC ... correlations" between seasonal ambient air pollutants and pregnancy loss ... of the highest levels of air pollution of all ...
(Date:4/23/2014)... disease, most in their mid-thirties and forties, face ... decline within two decades. "Mutant" protein clusters, long ... have been the primary focus of therapies in ... research from Prof. Gerardo Lederkremer and Dr. Julia ... Research and Immunology, in collaboration with Prof. Ulrich ...
Breaking Biology News(10 mins):How a plant beckons the bacteria that will do it harm 2How a plant beckons the bacteria that will do it harm 3Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2On the defensive 2On the defensive 3
... insight into genetic basis of human diseaseHigh-throughput sequencing of ... which can give clues to the genetic underpinning of ... information from the individual's two chromosomes. Yet many ... individuals' DNA at the level of each chromosome -- ...
... Prehistoric big game hunters and not the last ice age ... sloths and other North American great mammals such as mammoths, ... , Determining whether the first arrival of humans or the ... last Ice Age was responsible for the demise of prehistoric ...
... The National Programme on Substance Abuse Deaths (np-SAD) based at ... London, has found that there has been a decline in ... to 1,372 in 2004, a drop of eight per cent. ... for the year 2004 reported by Coroners and Procurators Fiscal ...
Cached Biology News:California computer scientists double volume of data in NIH biotech repository 2California computer scientists double volume of data in NIH biotech repository 3California computer scientists double volume of data in NIH biotech repository 4Study shows big game hunters, not climate change, killed off sloths 2Study shows big game hunters, not climate change, killed off sloths 3Continued reduction in the number of drug-related deaths in the UK 2Continued reduction in the number of drug-related deaths in the UK 3
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an ... products to serve the wound care market. , Free ... Alliqua was restructured with a seasoned management team and ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
(Date:1/14/2014)... 2014 Global Record Systems, LLC, ... technology solutions for patients, physicians, the biopharmaceutical industry, ... today the signing of a three-year Research Collaboration ... Administration (FDA). This initiative is designed to ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... ALTO, Calif., Dec. 2 Intradigm Corporation, a ... today,announced the issuance of United States patent 7,459,547, ... Silencing." The issued,patent, which is based on ... Stone Cook Chair of Biomedical Sciences and Professor ...
... 2 Cardiogenesis Corporation (Pink Sheets: CGCP), a leading developer ... from severe angina, today announced the addition of veteran medical ... Cohen as a member of the Company,s Board of Directors, ... , Mr. Cohen, 49, has over ...
... ENDO ), an innovative medical device ... used by urologists and,interventional radiologists for tissue and ... institutions including Mayo Clinic,Memorial Sloan-Kettering Cancer Center and ... among others, will present a total of 38 ...
Cached Biology Technology:Intradigm Announces Issuance of Key Patent Related to Enhancing Efficacy and Potency of RNAi Therapeutics 2Intradigm Announces Issuance of Key Patent Related to Enhancing Efficacy and Potency of RNAi Therapeutics 3Cardiogenesis Announces Addition of Raymond W. Cohen to Board of Directors 2Cardiogenesis Announces Addition of Raymond W. Cohen to Board of Directors 338 Cryoablation Studies, Exhibits Presented at National Radiological Society Meeting 238 Cryoablation Studies, Exhibits Presented at National Radiological Society Meeting 338 Cryoablation Studies, Exhibits Presented at National Radiological Society Meeting 4
... Start up kit. Includes configured Laptop PC ... 2 MultiBlock satellite thermal cyclers (non-robotic). ... User friendly software. Store/track run data. ... lid. Outstanding uniformity. Advanced control ...
Glycerokinase; from Bacillus stearothermophilus...
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
... Ascent FL is equipped ... luminometric measurement technologies that ... of advanced features of ... Ascent. Fluoroskan Ascent FL ...
Biology Products: