Navigation Links
New nanoparticles could revolutionize therapeutic drug discovery
Date:6/25/2009

A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development - opening up exciting possibilities in drug discovery.

Understanding the structure of proteins is a vital first step in developing new drugs, but to date, drug development has been slowed because due to their instability, proteins are difficult to work with in lab conditions. However, using nanoparticles, scientists from the Universities of Birmingham and Warwick have found a way to preserve membrane proteins intact, enabling detailed analysis of their structure and molecular functions.

These new findings, which have just been published online in the Journal of the American Chemical Society, will give scientists access to previously ignored proteins deemed too unstable to work with.

Professor Michael Overduin, from the University of Birmingham, who led the study, explained: "We have shown how a polymer can wrap around and preserve membrane proteins intact in stable nanoparticles. Membrane proteins are the most valuable but technically challenging targets for drug discovery. Finding a gentle solution that preserves their structure and activity, yet is robust enough for experimental interrogation, has eluded scientists for decades, but is now available."

Using a polymer - styrene maleic acid lipid particles (SMALPs), the researchers solubilised a pair of membrane proteins. They found that not only did the proteins maintain their folded structure, binding and enzyme activities in the SMALPs, but also that using the nanoparticles allowed them to be simply and rapidly used for virtually any laboratory analysis.

Advantages of SMALPs over traditional ways to solubilise proteins such as detergents include enhanced stability, activity and spectral quality
'/>"/>

Contact: Matt Goode
press.office@bbsrc.ac.uk
44-179-341-4694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. Shape matters in the case of cobalt nanoparticles
2. To fight drug addiction, UB researchers target the brain with nanoparticles
3. Magnetic nanoparticles navigate therapeutic genes through the body
4. The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes
5. Nanoparticles in the home: More and smaller than previously detected
6. UD researchers show that plants can accumulate nanoparticles in tissues
7. Workshop on environmental nanoparticles at UD, Nov. 10-11
8. MU scientists go green with gold, distribute environmentally friendly nanoparticles
9. $2M grant awarded to University of Kentucky for research on nanoparticles and human health
10. New ORNL process brings nanoparticles into focus
11. Nanoparticles assemble by millions to encase oil drops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... State University researchers have completed a 20-year study ... Hills prairie at different times of the year. ... late spring time frame has no measurable negative ... have multiple benefits. , The study was conducted ... Prairie Biological Station fire chief, and Joseph Craine, ...
(Date:7/31/2014)... July 31, 2014 -- Do people make a rational ... raise them that way? Is it a matter of ... and a colleague from Rice University say that neither ... people lean left while others lean right. , A ... deep-seated psychology are at the core of political differences, ...
(Date:7/31/2014)... the U.S. surgeon general issued a 101-page report about ... University published a paper breaking new ground on how ... responds when exposed to ultraviolet (UV) light. , The ... UV rays found in sunlight. This damage can lead ... , "Our paper advances foundational knowledge about how ...
Breaking Biology News(10 mins):Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3Scientists find growing consensus: Political attitudes derive from body and mind 2New paper describes how DNA avoids damage from UV light 2New paper describes how DNA avoids damage from UV light 3
... RIVERSIDE, Calif. Huanglongbing (HLB) or citrus ... Asian citrus psyllid , and poses a serious threat ... bacteria kill citrus by disrupting the trees, food transportation ... need sophisticated tools that rapidly characterize citrus varieties and ...
... JOLLA, Calif. , Nov. 20, 2013  Wellspring Biosciences, a ... novel drugs for the treatment of cancer, announced today a ... founders and chairman of its scientific advisory board, in the ... molecules that bind irreversibly to a common oncogenic mutant, K-Ras ...
... be a significant source of arsenic exposure regardless of arsenic ... finds. The study also confirms that toenail clippings are ... alcohol, Brussels sprouts and dark meat fish. Exposure to arsenic ... cancer, vascular diseases and low birth weight. The findings ...
Cached Biology News:Geneticists receive funding to improve citrus production and health 2Geneticists receive funding to improve citrus production and health 3Wellspring Biosciences Founder Publishes In Nature On Discovery of Small Molecule Inhibitors of K-Ras 2Dartmouth-led study shows diet alone can be significant source of arsenic 2
(Date:8/1/2014)... 1, 2014 Cambrex Corporation (NYSE: CBM ... 2014. Highlights , Second quarter ... the same period last year. , Second quarter EBITDA ... the same period last year (see table at the end ... increased, excluding the impact of foreign currency, to between 13% ...
(Date:7/31/2014)... 2014 Food and natural product ... for food alternatives that offer variety, as well ... ingredient market has numerous players operating in the ... Force Technology (VFT). VFT is a science-driven ... patterns, all tested to produce stable, effective and ...
(Date:7/31/2014)... July 31, 2014 Nearly 20,000 medical professionals ... Annual Meeting & Clinical Lab Expo in ... never-before-seen breakthroughs in diagnostic research and technology that will ... As of Wednesday, July 30, more than ... Meeting & Clinical Lab Expo, with more than 10,000 ...
(Date:7/31/2014)... see through organs and even the entire body to ... cellular structures has been a long-time dream of biologists. ... 31st in the journal Cell has now ... making opaque organs, bodies, and human tissue biopsies transparent, ... protocols could pave the way for a better understanding ...
Breaking Biology Technology:Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3See-through organs and bodies will accelerate biomedical discoveries 2
... , ... combination of Edman sequence analysis and electrospray tandem mass spectrometry provides accurate and ... Purpose , ... disulfide bridged peptides is greatly facilitated using a combination of the Procise cLC ...
... , , ... pesticide residues in food and environmental samples requires the use ... technologies. In this , application note the benefits ... is described. In particular the role of the collision cell in the MS/MS , ...
... housands of engineers and ... applications: test and measurement, process control and automation, ... choice due to its unparalleled connectivity to instruments, powerful ... interface, scalability, and overall function completeness. One need ...
Cached Biology Technology:Efficient Primary Structure Elucidation of Disulfide-bridged Peptides 2Efficient Primary Structure Elucidation of Disulfide-bridged Peptides 3Efficient Primary Structure Elucidation of Disulfide-bridged Peptides 4Efficient Primary Structure Elucidation of Disulfide-bridged Peptides 5Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 2Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 3Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 4LabVIEW for Measurement and Data Analysis 2LabVIEW for Measurement and Data Analysis 3LabVIEW for Measurement and Data Analysis 4LabVIEW for Measurement and Data Analysis 5LabVIEW for Measurement and Data Analysis 6LabVIEW for Measurement and Data Analysis 7LabVIEW for Measurement and Data Analysis 8LabVIEW for Measurement and Data Analysis 9LabVIEW for Measurement and Data Analysis 10LabVIEW for Measurement and Data Analysis 11LabVIEW for Measurement and Data Analysis 12LabVIEW for Measurement and Data Analysis 13LabVIEW for Measurement and Data Analysis 14LabVIEW for Measurement and Data Analysis 15