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New nano-tool synthesized at Scripps Research Institute
Date:4/13/2010

La Jolla, CA, April 13, 2010 -- Two chemists at The Scripps Research Institute have synthesized a new nano-scale scientific tool a tiny molecular switch that turns itself on or off as it detects metallic ions in its immediate surroundings.

Featured on the cover of the April 19, 2010 issue of the International Edition of the journal Angewandte Chemie, this molecule may be useful as a laboratory tool for controlling tiny reactions in the test tube, and it has potential to be developed as the basis of a new technology that could sensitively detect metals, toxins, and other pollutants in the air, water, or soil.

The molecule is named "ouroborand" after the mythical Ouroboros ("tail-eater" in Greek) a lizard-like creature that swallows itself head-to-tail. In mythology, the cyclic Ouroboros is always depicted with its tail in its mouth and this is usually taken as a symbol of eternity. In the Scripps Research laboratory where it was invented, the ouroborand molecule alternatively swallows or coughs out its taillike a switch that goes on or off as it senses metals.

This switching is possible because the molecule has a cup-like head at one end and a tail at the other. The tail can curl around and plug the cup just like the lizard swallowing its own tail.

"When no metals are present, the molecule's tail is held within its cavity at the other end," says Julius Rebek, Ph.D., who is the director of the Skaggs Institute for Chemical Biology at Scripps Research.

In the presence of zinc or other metal ions, the part of the molecule that links the head and the tail curls around the metal ions and pulls the head and the tail apart, springing the molecule open, says Rebek. Remove the metal, and the tail will move again to plug the other end of the molecule.

When Rebek and his postdoctoral fellow Fabien Durola synthesized the molecule and decided to name it ouroborand, they made a return of sorts to the dreams of chemi
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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

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