Navigation Links
New molecules discovered that block cancer cells from modifying cell DNA
Date:10/11/2007

Lake Tahoe, CA, October 11, 2007 Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications. The findings were presented today at the Prostate Cancer Foundations annual Scientific Retreat. Funding for the research was provided by the Prostate Cancer Foundation, as well as from the National Cancer Institute and the Avon Foundation.

Epigenetics refers to changes to genes other than changes to the DNA sequence itself, such as the addition of molecules to the DNA strand. While the development of cancer can arise from defective or mutated genes, it can also arise from these changes that can actually prevent a cell from acting as it should. Cancer cells exploit this process, putting some genes in cold storage or turned off by modifying the cell DNA in a process known as methylation.

Lead researcher William Nelson, M.D., Ph.D., Professor of Oncology and Urology at the Johns Hopkins Kimmel Cancer Center, explained the findings. One of the proteins in the cell that triggers this process is called a methyl-CpG binding protein, or MBD. We have discovered an antagonist of MBD2 that keeps this protein from binding to methylated genes. If the protein cant bind to the gene, then it cant keep the gene turned off and the gene is turned back on able to act in the way it is supposed to.

Nelson noted that the discovery is particularly exciting because of previous research that shows the importance of being able to alter the methylation process in DNA. When mice were developed without the gene that permits this process, they dont develop cancer. When the gene is removed from cancer cells, they turn on genes again in appropriate ways. The small molecules that weve discovered mimic thi
'/>"/>

Contact: Sharon Reis
prostate@gymr.com
202-745-5103
GYMR
Source:Eurekalert

Page: 1 2

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Inflammatory molecules released by pollen trigger allergies
3. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
4. Medical molecules designed to respond to visible light that can penetrate tissue
5. Touching Molecules With Your Bare Hands
6. DNA constraints control structure of attached macromolecules
7. Team Invents Device For Weighing Individual Molecules
8. Scientists discover that three molecules may be developed into new Alzheimers drugs
9. Physical and functional interaction of key cell growth molecules linked to cancer
10. Scientists discover new way to look at how molecules twist and turn on water
11. Scientists learn to predict protein-stabilizing ability of small molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... WHEN: , Saturday to Wednesday, Oct. 18-22, 2014 ... 111 W. Harbor Drive, San Diego, CA 92101 ... sessions and other presentations of the latest research ... Opening plenary session featuring high-scoring abstracts on rare ... of various cancers, and treatment for sun sensitivity ...
(Date:8/21/2014)... successfully replicated one of the crucial steps in photosynthesis, ... which could manufacture hydrogen as a fuel. , "Water ... exciting prospect to use them to create hydrogen, and ... from the ARC Centre of Excellence for Translational Photosynthesis ... offers potential as a zero-carbon replacement for petroleum products, ...
(Date:8/20/2014)... 158 pregnant teenagers in Rochester, NY, nearly half engaged ... ice, cornstarch, vacuum dust, baby powder and soap, and ... Moreover, such teens had significantly lower iron levels as ... , Pregnant teens, regardless of pica, are at higher ... deficiency and anemia. Low iron in pregnant teens raises ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2Water and sunlight the formula for sustainable fuel 2Pica in pregnant teens linked to low iron 2
... HOUSTON -- A comprehensive drug development strategy that ... then narrows down to a small-molecule prototype has yielded ... ways, a team led by scientists at The University ... two papers published back-to-back online at the Proceedings ...
... to detect nuclear explosions and enforce the world,s nuclear ... volcanoes in the Northern Mariana Islands near Guam. The ... for forward deployment of U.S. military forces in the ... U.S. Geological Survey and Southern Methodist University in Dallas ...
... provide powerful protection against risks her baby faces in the ... the journal Biological Psychiatry . The research shows that ... to be a harbinger for babies, poor cognitive development ... care during infancy and toddler-hood. The new study represents ...
Cached Biology News:New strategy develops 2 prototype drugs against cancer, retinal diseases 2New strategy develops 2 prototype drugs against cancer, retinal diseases 3Volcano monitoring will target hazard threat to Marianas, US military and commercial jets 2Volcano monitoring will target hazard threat to Marianas, US military and commercial jets 3Volcano monitoring will target hazard threat to Marianas, US military and commercial jets 4Good parenting triumphs over prenatal stress 2Good parenting triumphs over prenatal stress 3
(Date:8/21/2014)... Aug. 21, 2014  China Cord Blood Corporation (NYSE: ... to release financial results for the first quarter of ... market close in the US.  The ... ET on Friday, August 29, 2014 to discuss its ... Company,s recent developments, followed by a question and answer ...
(Date:8/21/2014)... August 21, 2014 Gallus ... contract development and manufacturing organization (CMO) announced today ... Inc., an oncology company focused on the development ... to manufacture the anti-prostate specific membrane antigen (PSMA) ... candidate. Under the agreement the antibody will ...
(Date:8/20/2014)... analysis of patented university inventions licensed to biotechnology ... to commercialization. To open these roadblocks, the researchers ... during the discovery stage could lead to faster ... frequently derived from discoveries made in university laboratories ... known during clinical trials, which have a high ...
(Date:8/20/2014)... Livermore, California (PRWEB) August 20, 2014 ... to develop and apply the most complete climate ... challenging and demanding climate change issues. , Eight ... combining forces with the National Center for Atmospheric ... in the new effort. Other participating national laboratories ...
Breaking Biology Technology:China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... Technology Center (HTC), Texas, largest technology incubator and ... of Entrepreneurs . "  The event honored local entrepreneurs ... economy; and developed lifesaving and revolutionary technologies. ... TechTrans International, Inc., as this year,s honoree. As the Founder ...
... May 20, 2012 A team of Australian scientists has ... of people with bowel cancer. The discovery has ... would signal the early stages of bowel cancer. This test ... programs and encouraging those at risk to have a colonoscopy. ...
... NEW YORK, May 17, 2012   Pharmaceutical companies ... value could have an advantage in the competition for ... published today by the Health Research Institute (HRI) at ... to know how well a drug will work and ...
Cached Biology Technology:Leading Technology Incubator Honors Extraordinary Entrepreneurs 2Leading Technology Incubator Honors Extraordinary Entrepreneurs 3Australian Discovered Biomarkers Map Path to New Blood Test for Bowel Cancer 2Australian Discovered Biomarkers Map Path to New Blood Test for Bowel Cancer 3New Competitive Arena Emerges for Pharmaceutical Companies in Healthcare's Changing Payment Landscape, Finds PwC Health Research Institute Study 2New Competitive Arena Emerges for Pharmaceutical Companies in Healthcare's Changing Payment Landscape, Finds PwC Health Research Institute Study 3New Competitive Arena Emerges for Pharmaceutical Companies in Healthcare's Changing Payment Landscape, Finds PwC Health Research Institute Study 4New Competitive Arena Emerges for Pharmaceutical Companies in Healthcare's Changing Payment Landscape, Finds PwC Health Research Institute Study 5New Competitive Arena Emerges for Pharmaceutical Companies in Healthcare's Changing Payment Landscape, Finds PwC Health Research Institute Study 6
... RNase H- Reverse Transcriptase ... version of SuperScript™ II ... SuperScript™ II it synthesizes ... from single-stranded RNA DNA ...
versican (H-56)...
... Heraeus HERAcell is the ideal CO2 incubator ... of ova or embryos at or near ... to provide everything needed to protect and ... Safe and stable incubation conditions ensure optimum ...
... presents PsiPort Mass Directed Auto Purification ... data acquisition system designed for automated ... life science and pharmaceutical discovery programs. ... to simplify high throughput mass directed ...
Biology Products: