Navigation Links
New molecules discovered that block cancer cells from modifying cell DNA
Date:10/11/2007

Lake Tahoe, CA, October 11, 2007 Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications. The findings were presented today at the Prostate Cancer Foundations annual Scientific Retreat. Funding for the research was provided by the Prostate Cancer Foundation, as well as from the National Cancer Institute and the Avon Foundation.

Epigenetics refers to changes to genes other than changes to the DNA sequence itself, such as the addition of molecules to the DNA strand. While the development of cancer can arise from defective or mutated genes, it can also arise from these changes that can actually prevent a cell from acting as it should. Cancer cells exploit this process, putting some genes in cold storage or turned off by modifying the cell DNA in a process known as methylation.

Lead researcher William Nelson, M.D., Ph.D., Professor of Oncology and Urology at the Johns Hopkins Kimmel Cancer Center, explained the findings. One of the proteins in the cell that triggers this process is called a methyl-CpG binding protein, or MBD. We have discovered an antagonist of MBD2 that keeps this protein from binding to methylated genes. If the protein cant bind to the gene, then it cant keep the gene turned off and the gene is turned back on able to act in the way it is supposed to.

Nelson noted that the discovery is particularly exciting because of previous research that shows the importance of being able to alter the methylation process in DNA. When mice were developed without the gene that permits this process, they dont develop cancer. When the gene is removed from cancer cells, they turn on genes again in appropriate ways. The small molecules that weve discovered mimic thi
'/>"/>

Contact: Sharon Reis
prostate@gymr.com
202-745-5103
GYMR
Source:Eurekalert

Page: 1 2

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Inflammatory molecules released by pollen trigger allergies
3. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
4. Medical molecules designed to respond to visible light that can penetrate tissue
5. Touching Molecules With Your Bare Hands
6. DNA constraints control structure of attached macromolecules
7. Team Invents Device For Weighing Individual Molecules
8. Scientists discover that three molecules may be developed into new Alzheimers drugs
9. Physical and functional interaction of key cell growth molecules linked to cancer
10. Scientists discover new way to look at how molecules twist and turn on water
11. Scientists learn to predict protein-stabilizing ability of small molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... minerals and organic compounds in hydrothermal environments are critical ... energy for the deep biosphere, and may have implications ... known about how minerals influence organic reactions. A ... how a common mineral acts as a catalysts for ... toxic solvents or expensive reagents. , At the heart ...
(Date:7/28/2014)... , a wild relative of the domestic tomato, has ... the labs headed by Professors Neelima Sinha and Julin ... The new genome information may help breeders produce tastier, ... in the journal Nature Genetics , was lead ... Germany. The UC Davis labs carried out work on ...
(Date:7/28/2014)... has identified areas of the Earth that are high ... , Europe is particularly vulnerable, as it has the ... cent, of any continent in ,refugia, areas of ... conditions remain relatively constant during times of great environmental ... mostly in Scandinavia and Scotland. , The biggest ...
Breaking Biology News(10 mins):Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
... iCargo project (Intelligent Cargo in Efficient and Sustainable Global ... to an improvement in the efficiency of intermodal loading ... decision making. It comprises 29 European organisations with experience ... It has a budget totalling 17,000,000 and a duration ...
... international team of scientists using a new X-ray method ... living frog embryo in greater detail than ever before., ... research and the search for new treatments for genetic ... fr Technologie in Germany, in collaboration with the Advanced ...
... FASEB MARC (Maximizing Access to Research Careers) Program has ... Developmental Biology (SDB) 72nd Annual Meeting in Cancun, Mexico ... promote the entry of students, postdoctorates and scientists from ... community and to encourage the participation of young scientists ...
Cached Biology News:New logistics services that will cut energy consumption and CO2 emissions 2New X-ray method shows how frog embryos could help thwart disease 2
(Date:7/30/2014)... 30, 2014 Connecticut Center for Advanced ... in East Hartford, Conn., was awarded a Rural Business ... a project that will determine the feasibility of implementing ... Connecticut. USDA Rural Development provided $53,000 for CCAT under ... second phase of the feasibility study in fiscal year ...
(Date:7/30/2014)... July 30, 2014 Vala Sciences ... U.S. Environmental Protection Agency (EPA). This new contract ... toxicity models, including tests designed to assess the ... the formation of connections between neurons (synapses), which ... and synapse formation by environmental pollutants likely contributes ...
(Date:7/30/2014)... July 30, 2014 Adding to their ... weighing boat special – Buy 2 of any ... promotion will benefit lab technicians looking for durable and ... are ideal for multiple applications including weighing liquids, solid, ... of choices including diamond-shaped, hexagonal, square, aluminum weighing, and ...
(Date:7/30/2014)... Henderson, CA (PRWEB) July 30, 2014 ... hosting presentations of leading Immunologists, Principle Investigators, scientists ... Charles J Malemud, Professor at Case Western ... be delivering his keynote address on “The ... TNF-a in production of matrix metalloproteinase-9”. Arya Biragyn, ...
Breaking Biology Technology:USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3
... artist Steven Seagal has written an open letter to Russian ... the "Russia 2045" movement that aims to make Russia the ... "Russia 2045," by using and developing new technologies, hopes to ... by the year 2045. "Not so long ago, ...
... Del., May 16, 2011 Children taking medication for ... heart problems or heart-related deaths than those who were ... online today in the journal, Pediatrics . ... the University of Pennsylvania and HealthCore Inc., drew data ...
... N.J., May 16, 2011 Palatin Technologies, Inc. (NYSE Amex: ... sexual dysfunction indications and PL-3994 for acute asthma and other ... 31, 2011. Recent Highlights ... Drug Administration (FDA), Palatin submitted a revised protocol to the ...
Cached Biology Technology:Steven Seagal Asks For Russian PM Vladimir Putin's Support in Immortality Research 2Pediatrics Study Finds Children Taking ADHD Medications Did Not Suffer More Serious Heart Problems or Cardiovascular-related Death 2Pediatrics Study Finds Children Taking ADHD Medications Did Not Suffer More Serious Heart Problems or Cardiovascular-related Death 3Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 2Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 3Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 4Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 5Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 6
... save space and organize gloves, safety ... They are the perfect benchtop storage ... labs, processing and manufacturing. Clear static-dissipative ... particles they attract. Many other sizes ...
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Mammals microRNA Microarray ...
... Proteolytic degradation is critical to the ... and regulatory proteins as important and ... metabolism, heat shock and stress response, ... receptors and ion channels, cell cycle ...
... critical to the maintenance of appropriate ... as important and diverse as those ... and stress response, antigen presentation, modulation ... channels, cell cycle regulation, transcription, and ...
Biology Products: