Navigation Links
New molecule protects brain from detrimental effects linked to diabetes and high blood sugar
Date:1/28/2014

Researchers at the Hebrew university of Jerusalem have created a molecule that could potentially lower diabetic patients' higher risk of developing dementia or Alzheimer's disease.

Recent studies indicate that high levels of sugar in the blood in diabetics and non-diabetics are a risk factor for the development of dementia, impaired cognition, and a decline of brain function. Diabetics have also been found to have twice the risk of developing Alzheimer's disease compared to non-diabetics. Now, researchers from the Hebrew University of Jerusalem have found a potential neuro-inflammatory pathway that could be responsible for the increases of diabetics' risk of Alzheimer's and dementia. They also reveal a potential treatment to reverse this process.

The research group led by Prof. Daphne Atlas, of the Department of Biological Chemistry in the Alexander Silberman Institute of Life Sciences at the Hebrew University, experimented with diabetic rats to examine the mechanism of action that may be responsible for changes in the brain due to high sugar levels. The researchers found that diabetic rats displayed high activity of enzymes called MAPK kinases, which are involved in facilitating cellular responses to a variety of stimuli, leading to inflammatory activity in brain cells and the early death of cells.

The study shows that the diabetic rats given a daily injection of the sugar-lowering drug rosiglitazone for a month enjoyed a significant decrease in MAPK enzyme activity accompanied by a decrease in the inflammatory processes in the brain. According to the authors, this finding represents the first unequivocal evidence of a functional link between high blood sugar and the activation of this specific inflammatory pathway in the brain.

Using the diabetic rat model, they explored a novel approach that would lower the activation of these enzymes in the brain, and decrease neuronal cell death. In the last few years, Prof. Atlas developed a series of molecules that mimic the action of thioredoxin called thioredoxin-mimetic peptides (TXM), whose role is to protect the cells from early death through activating inflammatory pathways. The TXM peptides were effective in different animal models and were able to prevent the activation of the damaging MAPK kinases. Applied to the diabetic Zucker rats, one of the molecules, TXM-CB3, significantly reduced the activity of these enzymes, and lowered the accelerated brain cell death. These results indicate that the molecule managed to cross the blood-brain barrier and improve the condition of the brain cells, through lowering the inflammatory processes in the rats' brains, despite the high glucose levels afflicting the rats.

The Hebrew University's Prof. Atlas said: "This study paves the way for preventive treatment of damages caused by high sugar levels, and for reducing the risk of dementia and Alzheimer's disease in diabetics or people with elevated blood sugar levels. Following the successful animal testing of the molecule we developed, we hope to explore its potential benefit for treating cognitive and memory impairments caused by diabetes on humans."

The molecule is protected by a patent registered by Yissum Research Development Company, the technology transfer arm of the Hebrew University.

The study, "Thioredoxin-Mimetic peptide CB3 Lowers MAPKinsase activity in the Zucker Rat Brain," appeared in the journal Redox Biology, an official Journal of the Society for Free Radical Biology and Medicine and the Society for Free Radical Research-Europe.


'/>"/>

Contact: Dov Smith
dovs@savion.huji.ac.il
972-258-82844
The Hebrew University of Jerusalem
Source:Eurekalert  

Related biology news :

1. Programming smart molecules
2. Missing molecule in chemical production line discovered
3. New tool developed for profiling critical regulatory structures of RNA molecules
4. New microscope captures movements of atoms and molecules
5. Wellspring Biosciences Founder Publishes In Nature On Discovery of Small Molecule Inhibitors of K-Ras
6. SlipChip counts molecules with chemistry and a cell phone
7. Penn Dental Medicine team identifies molecule critical to healing wounds
8. Lawrence Livermore researchers unveil carbon nanotube jungles to better detect molecules
9. BUSM researchers identify molecule that could aid lung cancer detection, treatment
10. Biomolecules for the production line
11. MicroRNA molecule found to be a potent tumor-suppressor in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New molecule protects brain from detrimental effects linked to diabetes and high blood sugar
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/1/2016)... , June 1, 2016 Favorable ... Election Administration and Criminal Identification to Boost Global Biometrics ... recently released TechSci Research report, " Global Biometrics Market ... Competition Forecast and Opportunities, 2011 - 2021", the global ... by 2021, on account of growing security concerns across ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... -- Andrew D Zelenetz , ... Published recently in Oncology & ... Andrew D Zelenetz , discusses the fact ... placing an increasing burden on healthcare systems worldwide, ... the patents on many biologics expiring, interest in ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
Breaking Biology Technology: