Navigation Links
New molecule can tangle up DNA for more than 2 weeks
Date:2/14/2012

stay there long enough to be therapeutically meaningful.

"Those are the big hurdles, but we jumped over two of them," says Iverson. "I'll give presentations in which I begin by asking: Can DNA be a highly specific drug target? When I start, a lot of the scientists in the audience think it's a ridiculous question. By the time I'm done, and I've shown them what we can do, it's not so ridiculous anymore."

In order to synthesize their binding molecule, Iverson and his colleagues begin with the base molecule naphthalenetetracarboxylic diimide (NDI). It's a molecule that Iverson's lab has been studying for more than a decade.

They then piece NDI units together like a chain of tinker toys.

"It's pretty simple for us to make," says Amy Rhoden Smith, a doctoral student in Iverson's lab and co-author on the paper. "We are able to grow the chain of NDIs from special resin beads. We run reactions right on the beads, attach pieces in the proper order and keep growing the molecules until we are ready to cleave them off. It's mostly automated at this point."

Rhoden Smith says that the modular nature of these NDI chains, and the ease of assembly, should help enormously as they work toward developing molecules that bind to longer and more biologically significant DNA sequences.

"The larger molecule is composed of little pieces that bind to short segments of DNA, kind of like the way Legos fit together," she says. "The little pieces can bind different sequences, and we can put them together in different ways. We can put the Legos in a different arrangement. Then we scan for sequences that they'll bind."


'/>"/>
Contact: Daniel Oppenheimer
oppenheimer@austin.utexas.edu
512-745-3353
University of Texas at Austin
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UH Manoa researchers discover novel chemical route to form organic molecules
2. Simpler times: Did an earlier genetic molecule predate DNA and RNA?
3. New synthetic molecules treat autoimmune disease in mice
4. Twisting molecules by brute force: A top-down approach
5. Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology
6. Scripps research scientists develop brand new class of small molecules through innovative chemistry
7. Bacteria responsible for common infections may protect themselves by stealing immune molecules
8. Molecule serves as a key in some protein interactions
9. Study identifies molecules used by certain species of seaweed to harm corals
10. Medical College of Wisconsin researchers show molecule inhibits metastasis
11. Sexual selection by sugar molecule helped determine human origins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New molecule can tangle up DNA for more than 2 weeks
(Date:12/22/2014)... 2014  The 2014 Holiday Season may be ... Acuity Market Intelligence reports that the long anticipated ... Acuity forecasts that intensifying demand for smart phones, ... will drive a global market of 2.5 billion ... 2020.   According to Maxine ...
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... -- Automation is fundamentally transforming the travel experience and ... borders. Over the past decade, ePassports, biometric readers, ... to self process through border control via eGates ... increasing number of airports, seaports, and land borders ... Maxine Most , Principal at Acuity Market ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... is not a steady march towards ever more sophisticated beings ... pointless, according to findings published by a team of researchers ... Department of Biochemistry. "Aristotle was the first to classify organisms ... of evolution continued this idea, with the concept of a ...
... Green technologies developed at The University of Nottingham have ... aimed at reducing global warming and tackling climate change. ... Rushlight Awards, attracting two prizes for innovations that will ... the developing world and help to make homes of ...
... are related to complex species including vertebrates (such as humans) ... an evolutionary link between simple animals such as jellyfish and ... implies that they have not always been as simple as ... and Acoelomorpha are very simple animals ...
Cached Biology News:New evolutionary research disproves living missing link theories 2Nottingham success in green technologies awards 2Nottingham success in green technologies awards 3Simple marine worms distantly related to humans 2
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014  ( ... that CoPatient, an online medical bill review and advocacy ... offering in the FREE WellCard Savings discount health services ... medical bill that was more than they expected to ... members reduce health care costs, WellCard Savings is pleased ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a ... a network of more than 20 contributing fertility ... fast access to a national pool of frozen ... Associates of Memphis is the only fertility clinic in ... Dr. William Kutteh , director of Fertility Associates ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... 19, 2014 Bina Technologies, Inc. (Bina, ... they have been acquired by Roche (SIX: RO, ROG; ... held company that provides a big data platform for ... data for the academic and translational research markets.  Bina ... will continue to focus on development of their innovative ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... (AIM: NWBS and NWBT; OTC Bulletin Board: NWBO) (the,"Company") ... Rajhi Holdings,through the subscription of 1,000,000 new shares in ... share. The new stock is expected to be ... shares will not be tradable on the,Company,s OTC bulletin ...
... Relations, a Top 25 independent PR agency announced today the ... Group and the Yan Center for Corrective & Cosmetic Surgery, ... clientele. Both medical centers have tasked 5WPR to proactively direct ... Kent Holtorf and the Yan Center have selected 5W PR ...
... iCo Therapeutics Inc. (TSX-V: ICO) is pleased to announce ... financing provides the company with sufficient capital to develop ... clinical trial. iCo-007 is targeting the treatment of Diabetic ... company with additional working capital. iCo,s partner Isis Pharmaceuticals ...
Cached Biology Technology:Northwest Biotherapeutics Secures $700,000 Equity Financing 2The Holtorf Medical Group and Yan Center for Corrective & Cosmetic Surgery Tap 5W Public Relations 2iCo Therapeutics Closes $1.3 Million Private Placement 2iCo Therapeutics Closes $1.3 Million Private Placement 3
... comprehensive microarray service for systematic discovery ... non-coding RNAs (ncRNAs) using a novel ... which enables highly sensitive and specific ... This comprehensive service includes custom probe ...
... The AccuSpot automates LC micro-fractionation, ... With the AccuSpot system, LC eluent ... onto target plates, in trace amounts. ... target plates for MALDI-TOF-MS measurements. When ...
... Sigmas 10 Capillary Electrophoresis Running Buffer ... and high throughput demands of todays sequencing ... supplier of TBE to the gel-based sequencing ... large scale capacity to meet your buffer ...
... and far-infrared range FT-IR spectrometers give you ... class. Yet all this comes at an ... Having a larger and faster mirror ... conventional FT-IRs provides 300%,larger solid angle of ...
Biology Products: