Navigation Links
New molecular signaling cascade increases glucose uptake
Date:8/20/2010

Skeletal muscles combust both lipids and carbohydrates during exercise. The carbohydrates consist of both glycogen stored in the muscles as well as glucose extracted from the blood. Being a major sink for glucose disposal, skeletal muscle represents an important model tissue for studying the intracellular signaling pathways leading to increased glucose transport.

This is important because it is known that the contraction-induced signaling to stimulate glucose transport is distinct from that utilized by insulin. Thus, for individuals in which insulin only has little effect (insulin resistance) the contraction-induced pathway represents an alternative pathway to increase glucose uptake. For pharmaceutical companies this pathway represents a possible and attractive alternative signaling pathway for pharmacological intervention in regulating glucose homeostasis.

Researchers from Department of Exercise and Sport Sciences, University of Copenhagen have in collaboration with scientists at the Joslin Diabetes Center, Harvard University focused on a novel protein called SNARK which was found be activated in skeletal muscle in response to contraction and exercise in both rodents and humans. Furthermore, by the use of transgenic animal models and by over-expressing an inactive mutant of SNARK in mouse skeletal muscle, it could be shown that contraction-induced glucose uptake was severely blunted by 40-50% compared with control animals.

The data in this study clearly support a role for SNARK in regulating glucose transport during muscle contraction and exercise, but it also strongly suggests that multiple, or redundant signals may mediate the effects of contraction on activating glucose transport.

These data have been published in Proceedings of the Nation Academy of Sciences (PNAS) on 16. August 2010 in an article called "Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mo
'/>"/>

Contact: Joergen Wojtaszewski
jwojtaszewski@ifi.ku.dk
452-875-1625
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology news :

1. AACR hosts molecular diagnostics conference in Denver, Colo.
2. American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists
3. WPI research shows how cranberry juice fights bacteria at the molecular level
4. Molecular biology provides clues to health benefits of olive oil
5. NSF grant will develop new online hub for biochemistry, molecular biology educators
6. Elsevier announces the winner of the Ahmed Zewail prize in molecular sciences
7. Molecular discovery suggests new strategy to fight cancer drug resistance
8. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
9. Molecular methods are not sufficient in systematics and evolution
10. Team led by Scripps Research scientists discovers bodys own molecular protection against arthritis
11. Pitt pharmacologists go on a molecular fishing trip and hook prize catch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... traditional cigarettes, but still release toxins into the ... , Scientists studying secondhand smoke from e-cigarettes discovered ... particles, with close-to-zero exposure to organic carcinogens. However, ... second-hand e-cigarette smoke were found to be significantly ... of polycyclic aromatic hydrocarbons cancer-causing organic compounds ...
(Date:8/28/2014)... at the University of Minnesota have developed an animal ... used for muscle regeneration research as well as studies ... The research is published in the current edition of ... no treatment for FSHD, which is thought by many ... FSHD is an unusual genetic disorder because, unlike most ...
(Date:8/28/2014)... -- Scientists have identified the developmental on-off switch for ... produce more than two-thirds of the world,s naturally derived ... to see whether it is possible to manipulate this ... , The study, appearing August 28 in Cell ... molecule called cyclic-di-GMP and a larger protein called BldD ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2UMN researchers find animal model for understudied type of muscular dystrophy 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3
... of government from around the world today agreed at a ... fill a serious void in leadership related to global water ... nonexistent," the retired leaders say the panel will work to ... a looming "water crisis." The 20 members of the ...
... In the treeless, flat Prairie, you,d think a city would ... up and roost in trees and buildings. But researchers at ... urban landscape is far from ideal for these animals. ... lecturer and recent PhD graduate in biological sciences at the ...
... Institute scientists has found a key biological mechanism underpinning ... door to the development of drugs to manage excessive ... much of our lab,s research, was to examine the ... drinking driven by the aversive aspects of alcohol withdrawal," ...
Cached Biology News:Void in leadership on world water crisis cited by 20 former heads of government 2Big city holds empty promise for bats 2Scripps Research scientists find key mechanism in transition to alcohol dependence 2Scripps Research scientists find key mechanism in transition to alcohol dependence 3
(Date:8/28/2014)... The ability for organizations to attract top ... individuals to perform at the highest of levels, are ... to compete in this post–recession era. The pharmaceutical ... the sector increasingly focuses on the importance of employee-fit ... real results on the organization's development and the innovation ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Supplementing ... offering a promotion for Eppendorf Safe Lock ... to purchase the highest quality tubes at an ... ideal for customers doing chemical, medical, pharmaceutical, and ... who are not regularly able to afford Eppendorf ...
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... right now. It's the new magic elixir that will solve ... swells. Then we'll go skipping off hand-in-hand through a sun-drenched ... was touting partnership just last week in this column, but ... the right relationship answer only if all involved are willing ...
... BLOOMFIELD HILLS, Mich. Logicalis , an international ... and storage solution providers, announced Monday it has acquired ... solution provider and one of IBM's top 10 Business ... also executed a letter of intent to purchase a ...
... advantage obsolete? Today, competitors can copy the newest ... or low-cost back-office process seemingly overnight. Indeed, it ... for long. This realization has led many corporate ... strategy to pursue is to create organizations that ...
Cached Biology Technology:Blooming partnerships 2Blooming partnerships 3Blooming partnerships 4Logicalis purchases Solution Technology for $90M 2Going beyond me, too customer experiences 2Going beyond me, too customer experiences 3Going beyond me, too customer experiences 4
... Jouan MSC series of Class II ... conditions and certification to the world's ... ensures that the cabinets cannot be ... Natural lighting, low noise and arm ...
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... designed for paramagnetic bead precipitation from standard ... plates with no additional accessories. The stand ... standard SBS 96-well microplate footprint. The use ... easy and fast (as little as 30 ...
... unit ideal for use in laboratories with low ... set at 12 rpm , Temperature control ... capacity of four 35 x 150mm bottles, eight ... , Consistent, repeatable results achieved with microprocessor ...
Biology Products: