Navigation Links
New molecular signaling cascade increases glucose uptake
Date:8/20/2010

Skeletal muscles combust both lipids and carbohydrates during exercise. The carbohydrates consist of both glycogen stored in the muscles as well as glucose extracted from the blood. Being a major sink for glucose disposal, skeletal muscle represents an important model tissue for studying the intracellular signaling pathways leading to increased glucose transport.

This is important because it is known that the contraction-induced signaling to stimulate glucose transport is distinct from that utilized by insulin. Thus, for individuals in which insulin only has little effect (insulin resistance) the contraction-induced pathway represents an alternative pathway to increase glucose uptake. For pharmaceutical companies this pathway represents a possible and attractive alternative signaling pathway for pharmacological intervention in regulating glucose homeostasis.

Researchers from Department of Exercise and Sport Sciences, University of Copenhagen have in collaboration with scientists at the Joslin Diabetes Center, Harvard University focused on a novel protein called SNARK which was found be activated in skeletal muscle in response to contraction and exercise in both rodents and humans. Furthermore, by the use of transgenic animal models and by over-expressing an inactive mutant of SNARK in mouse skeletal muscle, it could be shown that contraction-induced glucose uptake was severely blunted by 40-50% compared with control animals.

The data in this study clearly support a role for SNARK in regulating glucose transport during muscle contraction and exercise, but it also strongly suggests that multiple, or redundant signals may mediate the effects of contraction on activating glucose transport.

These data have been published in Proceedings of the Nation Academy of Sciences (PNAS) on 16. August 2010 in an article called "Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle".


'/>"/>

Contact: Joergen Wojtaszewski
jwojtaszewski@ifi.ku.dk
452-875-1625
University of Copenhagen
Source:Eurekalert

Related biology news :

1. AACR hosts molecular diagnostics conference in Denver, Colo.
2. American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists
3. WPI research shows how cranberry juice fights bacteria at the molecular level
4. Molecular biology provides clues to health benefits of olive oil
5. NSF grant will develop new online hub for biochemistry, molecular biology educators
6. Elsevier announces the winner of the Ahmed Zewail prize in molecular sciences
7. Molecular discovery suggests new strategy to fight cancer drug resistance
8. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
9. Molecular methods are not sufficient in systematics and evolution
10. Team led by Scripps Research scientists discovers bodys own molecular protection against arthritis
11. Pitt pharmacologists go on a molecular fishing trip and hook prize catch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one ... of their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has ... add Target to its list of well-respected retailers. This list includes such fine ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... SAN FRANCISCO , June 23, 2016   ... it has secured $1 million in debt financing from ... to ramp up automation and to advance its drug ... for its new facility. "SVB has been ... goes beyond the services a traditional bank would provide," ...
Breaking Biology Technology: