Navigation Links
New molecular insight into vertebrate brain development
Date:11/17/2008

In the December 1st issue of G&D, Dr. Fred H. Gage (The Salk Institute for Biological Studies) and colleagues reveal a role for the Hippo signaling pathway in the regulation of vertebrate neural development, identifying new factors and potential therapeutic targets that may be involved in congenital brain size disorders and neurological tumor formation.

Their paper will be made available online ahead of print on 11/17 at http://genesdev.org.

Establishing the basic embryonic brain requires the formation of a hollow neural tube, which serves as the rudimentary central nervous system, as well as the controlled proliferation and differentiation of neural progenitor cells into various specialized cell types.

The Hippo pathway is an ancient conserved signaling cascade that is known to regulate organ size in the fly and mouse. Previous research has demonstrated that Hippo signaling serves as a brake on cell growth and proliferation by preventing another protein, YAP, from entering the nucleus and activating pro-growth genes.

Drs. Xinwei Cao, Samuel Pfaff and Fred Gage now report that Hippo signaling is a critical master regulator of bran size in vertebrates that functions by restricting instructing the survival, proliferation and differentiation of neural precursor cells. In addition, the researchers identified the TEA domain (TEAD) transcription factor protein as the long-sought-after cognate DNA-binding partner of YAP in the nucleus.

Using genetic manipulation of chick embryos, the scientists demonstrated the consequences of altered Hippo signaling on vertebrate neural tube development. Increased YAP/TEAD activity induced neural progenitor cell overproliferation and the formation of an expanded neural progenitor cell population. Decreased YAP/TEAD activity led to increased cell death, while repression of YAP/TEAD target genes induced premature neuronal differentiation.


'/>"/>
Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. New molecular regulators of hyperthyroidism and goiter
2. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
3. UC health news: molecular pathway may predict chemotherapy effectiveness
4. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
5. Story ideas from Molecular & Cellular Proteomics
6. Lets talk -- new paradigms in the research of the biomolecular composition of water
7. Scientists unveil structure of molecular target of many drugs
8. Potential new therapeutic molecular target to fight cancer
9. NIH selects LIAI for major study on allergy molecular causes and possible treatments
10. Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
11. Leading cause of death in preemies might be controlled by resetting a molecular switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... available in German . ... built with the help of sophisticated assembly lines. Mobile assembly ... important part of these assembly lines. In the case of ... work stages arranged in a precise spatial and chronological sequence, ... line. , The creation of such an assembly line at ...
(Date:8/28/2014)... conserve biodiversity and more action is needed to ensure ... say. , Published in PLOS ONE , researchers ... Exeter, used meta-analysis - combining results from different studies ... research into these areas, to determine whether they actually ... Biological Sciences, said protecting an area from human exploitation ...
(Date:8/27/2014)... Aug. 27, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) ... underwritten public offering of units of common stock and ... gross proceeds of $20 million, prior to deducting underwriting ... Company.  The shares and warrants are immediately separable and ... sold in the offering consists of 2,000 shares of ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3Protected areas proven to protect biodiversity 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3
... Illinois at Chicago College of Pharmacy are attempting ... antipsychotic medication works in adults and children and ... a popular "atypical" antipsychotic medication, is used to ... disorder. , Jeffrey Bishop, assistant professor of ...
... With wheat stem sawfly natural enemies in demand, ... increasing their availability. , This fall, the ... mass-rearing parasitic wasps that attack wheat stem sawfly ... plants. The team includes entomologists David Weaver, master's ...
... tool developed at Cambridge University represents a breakthrough in ... Huntington's disease. , Researchers have developed an effective ... the disease, using an automated touch screen. It is ... more effectively the cognitive difficulties in other neurodegenerative disorders ...
Cached Biology News:Studies look at how genes affect antipsychotic drug response 2Rearing an army to save wheat 2Rearing an army to save wheat 3New technology to speed up research into Huntington's disease 2New technology to speed up research into Huntington's disease 3
(Date:8/28/2014)... MENLO PARK, Calif. , Aug. 28, 2014 ... company focused on developing novel mid- to late-stage ... raised $7.0 million in its first round of ... AshHill Biomedical Investments and Hercules Bioventures with participation ... biotech entrepreneur and pharmaceutical executive, Dr. Larry ...
(Date:8/28/2014)... Boston, MA (PRWEB) August 28, 2014 ... of wholesale construction materials, selected SoundConnect ... of their cloud based audio and web conferencing ... configured to support PrimeSource’s employees’ needs. SoundConnect ... technologies. , PrimeSource Building Products will be ...
(Date:8/27/2014)... Rhythm, a biopharmaceutical company developing peptide therapeutics that address ... disorders, announced today that it has filed a registration ... Exchange Commission (SEC) relating to the proposed initial public ... of shares to be offered and the price range ... Citigroup and Cowen and Company will act as ...
(Date:8/27/2014)... The Global and China Trifluoroacetic Acid Industry is ... of the Trifluoroacetic Acid industry in Global and China. ... industry, including definitions, applications and industry chain structure. Global ... with a focus on history, developments, trends and competitive ... and Chinese situation is also offered. , The report ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2Rhythm Files Registration Statement for Proposed Initial Public Offering 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... In a paper published this week in Science , ... and Professor Konstantin Novoselov has literally opened a third dimension ... prove the missing link for graphene to become the next ... is a remarkable material with endless unique properties, from ...
... 2012 InterMune, Inc. (NASDAQ: ITMN ) today ... year 2011 financial results at the close of the U.S. ... and webcast will be hosted by InterMune at 4:30 p.m. ... others may participate in the conference call by dialing 800-891-8257 ...
... Hudson, President and Scientific Director of The Ontario Institute ... to develop a framework for the implementation of personalized ... aims to integrate genomics research into everyday clinical practice, ... care for patients. Published in the journal ...
Cached Biology Technology:Graphene electronics moves into a third dimension 2InterMune to Release Fourth Quarter and Full Year Financial Results on February 9 2New Study Building Framework to Bring Personalized Medicine to the Clinic 2New Study Building Framework to Bring Personalized Medicine to the Clinic 3
Mouse monoclonal [SPM325] to Xanthine Oxidase, prediluted ( Abpromise for all tested applications). Antigen: C terminal 358 amino acid fragment of human xanthine oxidase. Entrez Gene ID: 749...
Rab1A...
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody...
Applications: Beadlyte® assay Stability: 2 years at 4°C (lyophilized) or 6 months at -20°C (rehydrated) ...
Biology Products: