Navigation Links
New model synapse could shed light on disorders such as epilepsy and anxiety
Date:8/8/2012

A new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction has been developed by a group of scientists led by Gong Chen, an associate professor of biology at Penn State University. The new method involves molecularly engineering a model synapse -- a structure through which a nerve cell send signals to another cell. This model synapse can precisely control a variety of receptors for the neurotransmitter called GABA, which is important in brain chemistry. The research, which will be published in the Journal of Biological Chemistry on 10 August 2012, opens the door to the possibility of creating safer and more-efficient drugs that target GABA receptors and that cause fewer side effects.

Neurotransmitters -- chemicals sent by nerves to trigger other cells to change their electrical responses -- interact with special receptors located on the cell's outer membrane. These receptors form inside the cell, and then are transported to different locations on the membrane to await the arrival of neurotransmitters. Chen explained that understanding how these receptors work and how they move to various locations on a cell's membrane is a critical step toward the development of new drugs targeting diseases that affect brain chemistry.

In their study, Chen and his team focused on a particular receptor -- called the GABA-A receptor-- that responds to the neurotransmitter GABA. "The GABA-A receptors are associated with various disorders in which nerve-cell excitability is altered, such as epilepsy and anxiety, and these receptors mediate major inhibition in the brain," Chen explained. "Each GABA-A receptor protein is made up of five subunits and there are 19 possible subunits that can combine in various ways to form any single receptor. We focused on a particular group of subunits called Alpha, and how changing these tiny subunits might affect the GABA
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. First model of how buds grow into leaves
2. Parkinsons disease stopped in animal model
3. New method for estimating parameters may boost biological models
4. Bone marrow transplant arrests symptoms in model of Rett syndrome
5. 3-D RNA modeling opens scientific doors
6. NCEAS researchers offer new ecological model for deep-water oil spills
7. Patel recognized with NSF Career Award for computer-modeling research on cell membranes
8. Model forecasts long-term impacts of forest land-use decisions
9. A cells first steps: Building a model to explain how cells grow
10. Computer model pinpoints prime materials for efficient carbon capture
11. The academic jungle: Ecosystem model reveals why women are driven out of science
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New model synapse could shed light on disorders such as epilepsy and anxiety
(Date:8/4/2015)... Aug. 04, 2015 ... has announced the addition of the ... and Service), Sub-Segment (Computer Forensics, Network Forensics, ... Types, Service, Vertical and Region - Global ... offering. By Component (Hardware, Software, ...
(Date:8/4/2015)... 2015  AMRI (NASDAQ: AMRI ) today reported financial and ... Highlights: , Second quarter contract revenue of ... , Adjusted contract margins of 26 % ... a $0.05 decrease in EPS from royalties in the current quarter ... "We are very pleased to present another strong financial ...
(Date:8/3/2015)... Calif. , Aug. 3, 2015 Synaptics, ... human interface solutions, today announced that members of the ... at the Pacific Crest Global Technology Leadership Forum on ... The conference will be held at the Sonnenalp Resort ... The presentation may include forward-looking information. An audio ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... Washington, D.C. (April 5, 2011) -- Sealants, like weather ... of a building, byproviding a barrier that prevents water ... out. The challenge, says research chemist Christopher White of ... Gaithersburg, Maryland, is predicting when they will fail. ...
... Spanish . Genetadi Biotech has presented to ... on Human Genetics held in Murcia - a prenatal diagnostic ... microarray technology (genomic hybridisation genetic chips) and with a diagnostic ... new device, known as Amniochip, is able to detect 150 ...
... our two closest living primate relatives, chimpanzees and bonobos, ... same genus. Now, a comparative analysis of their ... these behaviors, from the aggression more typical of chimpanzees ... is that the data appears to match what we ...
Cached Biology News:Inexpensive new instruments test building sealants under real-world conditions 2New technology capable of detection of 150 genetic syndromes from an amniocentesis 2Chimp, bonobo study sheds light on the social brain 2
(Date:8/4/2015)... Sinovac Biotech Ltd. (Nasdaq: SVA ), a leading ... , today announced that it will release its unaudited ... 2015, after market close on Wednesday, August 12, 2015. The ... 13, 2015, at 8:00 a.m. EDT (Thursday, August 13, ... the Company,s financial results and provide an update on ...
(Date:8/3/2015)... MARIETTA, Ga. , Aug. 3, 2015  MiMedx ... medicine company utilizing human amniotic tissue and patent-protected processes ... the Wound Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic ... will present at the 35 th Annual Canaccord|Genuity ...  Parker H. "Pete" Petit, Chairman and CEO, William ...
(Date:8/3/2015)...  Aethlon Medical, Inc. (Nasdaq: AEMD ), the ... diseases, today announced that it will host its First ... Thursday, August 13, 2015 at 4:30 p.m. Eastern Time. ... release of fiscal 2016 first quarter results.  A recorded ... hours after the call at the Investor Relations portion ...
(Date:8/3/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: REPCF), a ... autologous cell therapies, announced today that RepliCel,s CEO, David ... in Minneapolis, Minnesota on August 5 ... highlight RepliCel,s 18-month milestones including CE Mark for its RCI-02 ... clinical data from both RCT-01 (tendon) and RCS-01 (skin) clinical ...
Breaking Biology Technology:Sinovac to Host Conference Call to Report Second Quarter 2015 Unaudited Financial Results 2MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2
... 2010 Lexicon Pharmaceuticals, Inc. (Nasdaq: ... breakthrough treatments for human disease, today updated the progress ... for the three and nine months ended September 30, ... new mechanisms of action in irritable bowel syndrome and ...
... 5, 2010 Tomophase Corporation, a leading developer of ... announced that it has received an award from the ... for the Qualifying Therapeutic Discovery Project (QTDP.) ... sponsored program that is targeted to projects that show ...
... today released the first in a series of video ... technology correspondent Miles O,Brien and currently airing nationally on ... quick look at what happens when genius meets possibility: ... shaping our world. The 26-part video series is ...
Cached Biology Technology:Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results 2Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results 3Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results 4Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results 5Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results 6Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results 7Tomophase Receives Qualifying Therapeutic Discovery Project (QTDP) Award 2
... The ProLink Express is the first ... plate delivery and transfer operations with complete ... from initial bacterial colony picking through final ... system is capable of delivering a plate ...
...
... 3D structure visualization, phylogenetic tree building, sequence ... single application. Retrieve ... and filter them in real-time Organize ... searching, filtering and sorting Provides up-to-date ...
...
Biology Products: