Navigation Links
New model reveals pesticide-free method that takes a bite out of mosquito-borne disease
Date:2/10/2011

Scientists have modeled a system that may be used to control mosquitoes and the diseases they transmit, without the use of pesticides. In the proposed system, mosquitoes are engineered to carry two genes. The first gene causes males to transmit a toxin to females through their semen. The second gene, when expressed in females, makes them immune to this toxin. This research, published in the February 2011 issue of Genetics (http://www.genetics.org), describes a system that can be created using currently available molecular tools and could confine the spread of mosquitoes to isolated populations. It also allows the genes to be recalled if necessary.

"I hope that the results of this theoretical study will inspire molecular biologists to explore new ways of driving transgenes into populations," said John M. Marshall, Ph.D., a researcher involved in the work from the Department of Infectious Disease Epidemiology, School of Public Health at the Imperial College of London in the United Kingdom. "Ultimately, I hope that the application of these ideas will help move transgenic mosquito technology forward, and thereby contribute to the many efforts to reduce the prevalence of malaria and dengue fever in disease-endemic countries."

The gene transfer system was modeled using mathematical equations that describe how genetic alterations in the mosquitos' DNA are inherited from one generation to the next, and predict how these alterations will either spread or be eliminated from the population. The system has two basic componentsa toxin expressed in the semen of transgenic males that either kills female recipients or renders them infertile, and an antidote expressed in females that protects them from the effects of the toxin. An all-male release should result in population suppression because wild females that mate with transgenic males produce no offspring. A release that includes transgenic females propagat
'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Genetics Society of America
Source:Eurekalert

Page: 1 2

Related biology news :

1. New discoveries improve climate models
2. Mathematical model could help predict and prevent future extinctions
3. Purdue team creates engineered organ model for breast cancer research
4. Go figure: Math model may help researchers with stem cell, cancer therapies
5. Simple, ingenious way to create lab-on-a-chip devices could become a model for teaching and research
6. Mathematical model explains how complex societies emerge, collapse
7. Malaria modeling and control focus of workshop
8. Consortium studying mathematical modeling of influenza infection
9. Isogenic cell models for cancer research exclusively licensed to Horizon Discovery
10. La Jolla Institute validates Type 1 diabetes computer models predictive success through lab testing
11. Researchers devise computer model for projecting severity of flu season
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014) Scientists at the Barshop Institute for ... Medicine at the UT Health Science Center at San ... tissues of the longest-lived rodent, the naked mole rat. ... cells of naked mole rats protects and alters the ... and obsolete proteins. , The factor also protects proteasome ...
(Date:8/29/2014)... release is available in German . ... players in the natural nitrogen cycle on Earth and ... bacteria were thought to depend on nitrite as their ... by Holger Daims, a microbiologist at the University of ... hydrogen as an alternative source of energy. The oxidation ...
(Date:8/29/2014)... Boulder, Colo., USA - The rise of the Tibetan ... on Earth -- is important for both its profound ... In this study published in GSA Bulletin , ... -- "clumped" isotope thermometry -- using modern and fossil ... Zhada basin in southwestern Tibet. , Views range ...
Breaking Biology News(10 mins):Factor in naked mole rat's cells enhances protein integrity 2Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... (UH) executed two license agreements with SuperPower, a ... covers the intellectual property on second generation (2G) ... under the Sponsored Research Agreement (SRA) previously executed ... is led by Venkat Selvamanickam, M.D. Anderson chair ...
... the Ministry of Public Health and Sanitation, together with ... Adolescent Health), unveiled a renewed set of national policy ... by putting proven interventions to work within the country,s ... global progress against diarrhoea has stalled. Contrary to what ...
... with legends of European monarchs, frail heirs and one flamboyant ... the very treatments that can help can also put patients, ... an expensively produced protein that helps the blood to clot. ... and in a subset of those, it sets off an ...
Cached Biology News:SuperPower and UH sign high temperature superconducting wire license agreements 2Policy unveiled to combat diarrheal disease, a killer of Kenyan children 2Policy unveiled to combat diarrheal disease, a killer of Kenyan children 3Researchers harness the power of plants to fight hemophilia 2Researchers harness the power of plants to fight hemophilia 3Researchers harness the power of plants to fight hemophilia 4
(Date:8/28/2014)... Scientists, researchers, and technologists will converge ... Damage 2014 symposium. Marking its 46th year, the ... run 14-17 September. The event is sponsored by ... , The premier conference for basic and applied issues ... materials will engage researchers and engineers from numerous industries ...
(Date:8/28/2014)... MA (PRWEB) August 28, 2014 ... wholesale construction materials, selected SoundConnect to ... their cloud based audio and web conferencing platform ... to support PrimeSource’s employees’ needs. SoundConnect delivers ... , PrimeSource Building Products will be utilizing ...
(Date:8/27/2014)... August 27, 2014 Varian Medical Systems ... its current Salt Lake City manufacturing facility and allow ... Utah to ultimately create 1,000 new full time jobs ... , “Utah is home to hardworking people with immense ... credited with Varian’s success in the manufacturing of our ...
(Date:8/27/2014)... August 27, 2014 In 2013, ... Lawrence Livermore National Security LLC (LLNS), ... and deliver a state-of-the-art laser system for the ... Beamlines), under construction in the Czech Republic. , ... laser system, called the " High repetition-rate Advanced ...
Breaking Biology Technology:Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3PrimeSource Chooses SoundConnect as Collaboration Provider 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
...  A recent Van Andel Research Institute (VARI) study published in ... function of an essential plant hormone could profoundly change our ... to the development of new drugs for a variety of ... by the same team of investigators at VARI that was ...
... 2012  PinneyAssociates, Inc., a health care consulting firm with offices ... the following promotions, effective 1 January 2012: , ... , Lucy Owen, to Vice President, Program Operations and ... President , Joe Gitchell, to President , John ...
... Aethlon Medical, Inc. (OTCBB: AEMD), the ... address infectious disease, cancer and other life-threatening conditions, ... Therapy Scientific Advisory Board to guide the advancement ... from the Aethlon ADAPT™ system.  Aethlon recently established ...
Cached Biology Technology:Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process 2PinneyAssociates Announces Senior Staff Promotions 2Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 2Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 3Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 4Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 5Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 6Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 7
Request Info...
... CLS number is a new product ... product number. If showing no availability ... Sigma-Aldrich number (Z71,405-4) or contact customer ... 60 mm volume diam. 3 ...
Contact us for more information...
... to rapidly and reliably amplify unknown genomic ... APAgene provides hassle-free, ready-to use components, at ... are provided in each kit. The Genome ... filling, localized cloning of genomic DNA, isolating ...
Biology Products: