Navigation Links
New model predicts environmental effect of pharmaceutical products
Date:7/28/2011

Most synthetic chemical products used in consumer goods end up unchanged in the environment. Given the risks this could pose for the environment and human health, researchers from the Autonomous University of Barcelona (UAB) have developed a new tool to effectively predict what will happen to current and future pharmaceutical products.

Thousands of pharmaceutical products, which are increasingly diverse and increasingly used, are "partially" metabolised by the human body. Those that remain unchanged pass into the waste water treated at sewage plants, which are not always designed to eliminate synthetic organic compounds.

"Sometimes, some substrates can even revert to the original drug within the water treatment plant itself, increasing the concentration of the drug in the effluent discharged, as is the case with carbamazepine (a psychotropic anti-epilepsy drug)", Xavier Domenech, co-author of the study and a researcher at the Department of Chemistry of the UAB, tells SINC.

The result is that a great variety of drugs that could be harmful to wildlife end up in the environment. "This is of greater concern in the case of water treated for human consumption, in which we are increasingly detecting a cocktail of drugs at low concentrations (nanograms per litre), the long-term effect of which is unknown", explains Domenech.

Pinpointing the effect of a drug

The study, which has been published in Water Air and Soil Pollution, has made it possible to develop a new tool to determine the likelihood of drugs ending up in the environment, and at what concentrations, thereby fulfilling the European Medicines Agency (EMEA) requirement to evaluate the environmental risk of new drugs that are being proposed for marketing.

The new tool, developed by Marc Ribera, lead author of the study, uses some physical-chemical properties of pharmaceuticals and the rate of growth in their use in Spain between 1999 and 2006 to determine how they will behave in the environment. The drugs analysed are those that are most commonly consumed in Spain (more than 1 mg of active substance per person and year), including, among many others, ibuprofen, diazepam, naproxen, omeprazole and paracetamol.

In order to validate the model, the research team compared the model's prediction results on water with values measured by authors in rivers and lakes. "The model used is good at predicting the experimental data, and can be seen as a good predictive model for evaluating the environmental risks of current drugs and those that may be marketed in future", concludes Domenech.


'/>"/>

Contact: SINC Team
info@agenciasinc.es
FECYT - Spanish Foundation for Science and Technology
Source:Eurekalert  

Related biology news :

1. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
2. Models of eel cells suggest electrifying possibilities
3. Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
4. Swamping bad cells with good in ALS animal models helps sustain breathing
5. Moderate use averts failure of type 2 diabetes drugs in animal model
6. Multiple sclerosis research charges ahead with new mouse model of disease
7. A model to measure soil health in the era of bioenergy
8. New model predicts hot spots for mercury in fish
9. New movement models tested at the Smithsonian in Panama
10. Cytori reports benefit of adipose-derived regenerative cells in spinal disc model
11. Lifecycles of tropical cyclones predicted in global computer model
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New model predicts environmental effect of pharmaceutical products
(Date:6/22/2016)... , June 22, 2016  The American College of ... Trade Show Executive Magazine as one of the fastest-growing ... May 25-27 at the Bellagio in Las Vegas ... the highest percentage of growth in each of the following ... exhibiting companies and number of attendees. The 2015 ACMG Annual ...
(Date:6/22/2016)... On Monday, the Department of Homeland Security ... solutions for the Biometric Exit Program. The Request for ... (CBP), explains that CBP intends to add biometrics to ... United States , in order to deter visa ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... CLEVELAND , Nov. 30, 2016  GenomOncology today announced ... Vice President of Medical Affairs.  Dr. Coleman ... enhancing the company,s proprietary knowledge-enabled platform. The GenomOncology software suite ... of genetic sequencing data and clinical decision support, from quality ... , ...
(Date:11/30/2016)... 2016  The Allen Institute for Cell Science ... publicly available collection of gene edited, fluorescently tagged ... cellular structures with unprecedented clarity. Distributed through the ... are a crucial first step toward visualizing the ... makes human cells healthy and what goes wrong ...
(Date:11/30/2016)... 2016   Merck , ein führendes ... einer Reihe von Vereinbarungen mit Evotec AG ... Screeningleistungen für Mercks Palette genetischer Reagenzien wie ... diese Bibliotheken in Kombination mit Evotecs Expertise ... zur Ermittlung und Erforschung neuer Arzneimitteltargets.    ...
(Date:11/30/2016)... ... November 30, 2016 , ... Energetiq Technology, a world leader ... generation, ultra-bright, Laser-Driven Light Source, the EQ-77, at the MRS Fall Exhibit 2016. ... offers higher radiance and irradiance from a truly broadband white light source. The ...
Breaking Biology Technology: