Navigation Links
New model for treatment of obsessive-compulsive disorder created
Date:9/15/2011

s to begin.

"OCD is very mysterious and very prevalent," Shanahan said. "The development of OCD-specific treatments will be an extremely important step toward helping these people and preventing the disorder's cost to society."

With an animal model that replicates at least some aspects of OCD, researchers can dig deeper into the specific neurotransmitters and systems involved in the disorder. In Dulawa's laboratory, a team led by Shanahan found inspiration in a drug that activates the 1b class of receptors for the neurotransmitter serotonin. Clinically, the drug is used to treat migraines, but it is also known to have the unintended effect of increasing anxiety and compulsions in people with OCD.

When the drug was given to mice, they showed highly repetitive patterns of locomotion when placed into an open arena. The drug-treated mice also exhibited deficits in prepulse inhibition, a form of startle plasticity thought to measure the brain's ability to filter out intrusive thoughts, which plague OCD patients.

To determine whether these drug-induced behaviors reflected the neurobiology of OCD, the researchers tested the same drugs used to treat the disorder in humans. After four weeks of pre-treatment with SRIs the same duration required to see therapeutic effects in humans drug-induced OCD behaviors were reduced in the mice. Shorter SRI treatment or treatment with other antidepressant drugs that do not work in humans with OCD were unsuccessful in reducing the behaviors caused by the drug.

"We have this time course that nicely parallels or mimics the human therapeutic response," Shanahan said. "In order to study how these drugs are working and the pathophysiology of the disorder, we need a model where this delayed onset exists. So we are really excited about that."

The researchers then looked for a specific brain region where activation of 1b serotonin receptors creates OCD-like symptoms. In humans, scientists ha
'/>"/>

Contact: Robert Mitcum
robert.mitchum@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Engaging land-use stakeholders is model behavior
2. Using a mathematical model to evaluate microsatellite genotyping from low-quality DNA
3. Mapping a model: International research on plant species appears in journal Nature
4. A mouse model brings new perspectives on Lafora disease
5. A math-based model for deep-water oil drilling
6. Scale models
7. Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder
8. New model predicts environmental effect of pharmaceutical products
9. Modeling plant metabolism to optimize oil production
10. CWRU receives $2.1 million NIH grant to expand cystic fibrosis research models
11. Models show Coho salmon at risk in US urbanizing watersheds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... marine phytoplankton, such as the prolific bloomer Emiliania ... researchers have discovered. The finding contradicts the common view ... microbes depend on scarce supplies of thiamine in the ... to think about the ocean," says CIFAR Senior Fellow ... Journal paper with CIFAR fellows John Archibald ...
(Date:8/28/2014)... A free mobile app called TX Invasives is now ... The University of Texas at Austin for identifying harmful ... , Invasive species in the United States cause about ... they destroy agricultural crops, clog waterways, kill native plants ... TX Invasives app for reporting where invasive species occur, ...
(Date:8/28/2014)... The zebrafish, a ... pattern of blue stripes alternating with golden stripes. Three major ... cells emerge during growth in the skin of the tiny ... the characteristic colour pattern. ,While it was known ... proper stripes, the embryonic origin of the pigment cells that ...
Breaking Biology News(10 mins):Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Mobile app makes ID of harmful plants, insects in Texas a snap 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... other biological molecules, only exist today in a few ... Tom Ran and Shai Kaplan, research students in the ... Biological Chemistry, and Computer Science and Applied Mathematics Departments ... devices ,user friendly, even while performing complex computations and ...
... 30 /PRNewswire-FirstCall/ -- Aware, Inc. (Nasdaq: AWRE ... reported financial results for its second quarter ended June 30, 2009. ... quarter of 2009 were $5.8 million, a decrease of 7% compared ... the six months ended June 30, 2009, revenues decreased 14% to ...
... GEOLOGY studies include some curious associations: air hockey and ... Basalts and the Congo Fan; and rock hyrax middens ... on Mars; the only basin known to have both ... fish die-off; and mapping naturally occurring asbestos in the ...
Cached Biology News:DNA computation gets logical at the Weizmann Institute of Science 2Aware, Inc. Reports Second Quarter 2009 Financial Results 2Aware, Inc. Reports Second Quarter 2009 Financial Results 3Aware, Inc. Reports Second Quarter 2009 Financial Results 4Aware, Inc. Reports Second Quarter 2009 Financial Results 5Aware, Inc. Reports Second Quarter 2009 Financial Results 6Aware, Inc. Reports Second Quarter 2009 Financial Results 7Aware, Inc. Reports Second Quarter 2009 Financial Results 8August 2009 Geology and GSA Today media highlights 2August 2009 Geology and GSA Today media highlights 3August 2009 Geology and GSA Today media highlights 4August 2009 Geology and GSA Today media highlights 5August 2009 Geology and GSA Today media highlights 6August 2009 Geology and GSA Today media highlights 7August 2009 Geology and GSA Today media highlights 8August 2009 Geology and GSA Today media highlights 9August 2009 Geology and GSA Today media highlights 10August 2009 Geology and GSA Today media highlights 11August 2009 Geology and GSA Today media highlights 12August 2009 Geology and GSA Today media highlights 13August 2009 Geology and GSA Today media highlights 14August 2009 Geology and GSA Today media highlights 15
(Date:8/28/2014)... important devices in spintronics, an electronic which is ... but also on their spin and the spin-related ... into magnetic signals and vice versa. Recently, the ... Institute of Physics at Johannes Gutenberg University Mainz ... and Japan, has for the first time realised ...
(Date:8/28/2014)... --  SunTrust Robinson Humphrey (STRH) today announced ... equity research team in biotechnology and oilfield services.  ... research demonstrates our commitment to providing our valued ... investment decision making," said Biff Woodruff , ... make significant investments in differentiated content at a ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 ... is offering a promotion for Eppendorf Safe ... customers to purchase the highest quality tubes at ... are ideal for customers doing chemical, medical, pharmaceutical, ... technicians who are not regularly able to afford ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... Year-Over-Year Increase in Revenue; Gross Margin Increase ... Continues; Net Losses ... an innovative medical device company focused on the development of,minimally ... in revenues, cryoprobe sales and procedures and,continued expense reductions in ...
... Vical Incorporated (Nasdaq:,VICL) today announced that the company will ... before the opening of trading on,Thursday, May 8, and ... results and provide a company update at noon Eastern ... a listen-only basis to any interested,parties. The company will ...
... ORCH ), a leading worldwide provider of identity ... results on,Thursday, May 8, 2008 at approximately 7:00 a.m. ... discuss the results at 10:00 a.m. EDT on the,same ... quarter,2008 as well as operating highlights. A question-and-answer session ...
Cached Biology Technology:Endocare Reports 2008 First Quarter Financial Results 2Endocare Reports 2008 First Quarter Financial Results 3Endocare Reports 2008 First Quarter Financial Results 4Endocare Reports 2008 First Quarter Financial Results 5Endocare Reports 2008 First Quarter Financial Results 6Endocare Reports 2008 First Quarter Financial Results 7Endocare Reports 2008 First Quarter Financial Results 8Vical Announces News Release and Conference Call Schedule for First Quarter 2008 Financial Results 2Orchid Cellmark to Announce First Quarter 2008 Financial Results on May 8, 2008 2
Human FADD Affinity Purified Polyclonal Ab...
Immunogen: Synthetic peptide based on the sequence: SPSSGPSLTADSMWR Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
... is an inhibitor of ... concentration of inhibitor required ... must be determined empirically ... micromolar inhibitor is sufficient ...
Biology Products: