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New microscopes at NIH reveal live, developing cells in unprecedented 3-D clarity
Date:10/25/2013

it's in, how it moves around, could go a long way towards scientists' understanding of how infections occur and potentially how to fight them more effectively. In the same way, observing the migration of cancer cells in a 3-D environment could unlock information on how cancer grows, finds nutrients, and spreads.

"Biology is three-dimensional, not two dimensional. The nucleus of a cell is spherical, not circular, and as scientists, it's up to us to find ways to observe cells as accurately as possible, Shroff said. "We're really moving biology into the third dimension with this microscope." There's a lot of attention right now on how neurons fire and interact with each other, but the truth is, we don't even understand how a brain developseven in the most simple of organisms like C. elegans, a worm with only 300 brain cells. We don't know why brain cells go where they do or what determines their organization. We can't understand more about this process without observing it, and that's something that these devices can help to provide."

The Shroff lab has already begun multiple collaborations with biological labs both inside the NIH as well as external institutions, including Yale, Sloan Kettering, and the University of Connecticut Health Center.


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Contact: Jessica Meade
nibibpress@mail.nih.gov
301-496-3500
NIH/National Institute of Biomedical Imaging & Bioengineering
Source:Eurekalert  

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