Navigation Links
New microscopes at NIH reveal live, developing cells in unprecedented 3-D clarity
Date:10/25/2013

Researchers at NIH have developed two new microscopes, both the first of their kind. The first captures small, fast moving organisms at an unprecedented rate and the second displays large cell samples in three dimensions while decreasing the amount of harmful light exposure to the cells. Both microscopes surpass in clarity any other currently on the market.

The first microscope allows researchers to obtain fast moving images at double the spatial resolution of a conventional microscope. This provides a vastly clearer picture, enabling cell components that were once quite blurry to now become sharply defined; the difference is similar to that of a 1990's-era standard TV set versus today's high-definition TVs. The microscope is also 10 to 100 times faster than traditional technologies.

"It's always helpful to look at smaller and smaller things," said Hari Shroff, Ph.D., at NIH's National Institute of Biomedical Imaging and Bioengineering (NIBIB) lab chief of NIBIB's section on High Resolution Optical Imaging (HROI.) "Looking at a fixed cell at high resolution can tell you where different parts of the cell are at any given moment; but because much of biology depends on the movement of very small proteins finding each other and interacting, we really needed to look at how things move in a live cell."

The problem is that the higher the resolution, the harder it is to eliminate the blur from both light diffraction (the glow that sometimes occurs as light bends around objects) and the motion going on inside the live cell. Traditional linear structured illumination microscopy (SIM) cannot maintain the high resolution desired by researchers when the sample is moving quickly.

Shroff and his research fellow Andrew York, Ph.D., found an answer to these problems with their new instant linear structured illumination microscopy (iSIM), described in a paper published in Nature Methods on October 6th. Building on traditional SI
'/>"/>

Contact: Jessica Meade
nibibpress@mail.nih.gov
301-496-3500
NIH/National Institute of Biomedical Imaging & Bioengineering
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Research reveals first evidence of hunting by prehistoric Ohioans
2. Studies reveal structure of EV71, a virus causing childhood illnesses
3. Researchers reveal how a single gene mutation leads to uncontrolled obesity
4. Study reveals how monarch butterflies recolonize northern breeding range
5. Circadian rhythms have profound influence on metabolic output, UCI study reveals
6. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
7. Ancient civilizations reveal ways to manage fisheries for sustainability
8. Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean
9. Nature: Video reveals wave character of particles
10. Plant research reveals new role for gene silencing protein
11. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New microscopes at NIH reveal live, developing cells in unprecedented 3-D clarity
(Date:4/15/2014)... Puerto Rican community is creating a tropical home away ... has caught the attention of scientists. David W. Taylor ... Connecticut) took a close look at the fresh crops ... evidence that gives new meaning to a phrase that ... in the kitchen. , "Culinary preferences tell us a ...
(Date:4/15/2014)... University of Missouri researchers have previously shown that a ... exercise exists. In a new study, Frank Booth, a ... found a potential link between the genetic pre-disposition for ... which mental maturation occurs. , For his study, Booth ... activity or extreme laziness. Booth then put the rats ...
(Date:4/15/2014)... Case Western Reserve University dental researchers have found ... immune cells from the mouth to study how ... inflammation. , By isolating some specialized immune cells ... how they fight diseases in the mouthor reject ... hope to learn more about treating and preventing ...
Breaking Biology News(10 mins):The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3Genetic pre-disposition toward exercise and mental development may be linked 2New method isolates immune cells for researchers to study how they ward off oral diseases 2
... been named as one of the 2008 Environmental Scientists ... His half-brother, biologist Jules Blais, is the other winner ... prestigious in the environmental sciences. The prize recognizes the ... Smol is series editor of the Springer ...
... 2 BIO-key International,Inc. (OTC Bulletin Board: BKYI), ... identification solutions, today announced that it,has been awarded ... with a large multi-national technology company. BIO-key will,license ... be used on,multiple, large international and domestic opportunities., ...
... WI, JUNE 2, 2008-- An understanding how environmental ... transport and fate of agricultural chemicals in the ... degradation of surface and ground waters from past, ... has been conducted at field or smaller scales, ...
Cached Biology News:BIO-key(R) Awarded $2 Million Biometric Contract by Multi-National Company 2Holistic understanding: Ag chemicals in the environment 2
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... innovation and growth for Scottsdale’s Brain State Technologies®. ... team at Wake Forest University Medical Center who ... Susanne Marcus Collins Foundation, had research papers published ... Amy Grant highlighted Brainwave Optimization® in First for ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch ... an experimental new therapy for the treatment of tinnitus. ... for their unique tinnitus frequency, and over a period ... AudioNotch has previously provided Notched Sound Therapy in two ... is pleased to announce to release of a new ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , ... Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for ... those affected worldwide, will host its annual Crystal Ball ... Warrington, Pa. , Each year, the Crystal Ball ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... solutions based on the products of cells grown ... have entered into an international license agreement with ... Histogen’s proprietary multipotent cell conditioned media (CCM). ... the existing license between Histogen and Suneva Medical, ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... ... of Chronic Wounds, ... focused on improving patient quality of life, today,announced that its ... KFH Novo medical device, a breakthrough medical,technology that enhances the ...
... 11 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) announced ... 28th Annual Healthcare Conference on Tuesday, March 18, 2008 ... being held at the Boston,Marriot Copley Place., Steve ... Inc., will present an overview of Anadys and its ...
... 11 Nile Therapeutics,Inc. (OTC Bulletin Board: NILT), today ... financial results for 2007 after the market,closes on Thursday, ... and live webcast to discuss these financial results and ... 4:30 p.m. ET, 1:30 p.m. PT,that afternoon., Interested ...
Cached Biology Technology:Kingfisher Healthcare Receives European CE Mark for Next Generation Wound Healing Device 2Anadys Pharmaceuticals to Present at the Cowen and Company Healthcare Conference 2Nile Therapeutics to Announce 2007 Fourth Quarter and Full Year Financial Results on Thursday, March 13, 2008 2
... requiring mass detection but not structural ... Mass spectrometer is ideally suited for ... high performance mass analysis. Typical ... protein detection, micro-satellite DNA characterization and ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
... ideal small concentrator for the molecular biology ... water and organic solvents from a variety ... and round bottom flasks. Making it an ... ,The built-in special runs for working with ...
... suitable for use with a wide range ... to water and some of the higher ... of removing water and organic solvents from ... microplates, vials and round bottom flasks; making ...
Biology Products: