Navigation Links
New microscope reveals ultrastructure of cells
Date:11/19/2010

This release is available in German.

For the first time, there is no need to chemically fix, stain or cut cells in order to study them. Instead, whole living cells are fast-frozen and studied in their natural environment. The new method delivers an immediate 3-D image, thereby closing a gap between conventional microscopic techniques.

The new microscope delivers a high-resolution 3-D image of the entire cell in one step. This is an advantage over electron microscopy, in which a 3-D image is assembled out of many thin sections. This can take up to weeks for just one cell. Also, the cell need not be labelled with dyes, unlike in fluorescence microscopy, where only the labelled structures become visible. The new X-ray microscope instead exploits the natural contrast between organic material and water to form an image of all cell structures. Dr. Gerd Schneider and his microscopy team at the Institute for Soft Matter and Functional Materials have published their development in Nature Methods (DOI:10.1038/nmeth.1533).

With the high resolution achieved by their microscope, the researchers, in cooperation with colleagues of the National Cancer Institute in the USA, have reconstructed mouse adenocarcinoma cells in three dimensions. The smallest of details were visible: the double membrane of the cell nucleus, nuclear pores in the nuclear envelope, membrane channels in the nucleus, numerous invaginations of the inner mitochondrial membrane and inclusions in cell organelles such as lysosomes. Such insights will be crucial for shedding light on inner-cellular processes: such as how viruses or nanoparticles penetrate into cells or into the nucleus, for example.

This is the first time the so-called ultrastructure of cells has been imaged with X-rays to such precision, down to 30 nanometres. Ten nanometres are about one ten-thousandth of the
'/>"/>

Contact: Dr. Gerd Schneider
gerd.schneider@helmholtz-berlin.de
49-030-806-213-131
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Compact microscope a marvel
2. Computational microscope peers into the working ribosome
3. Microscope reveals how bacteria breathe toxic metals
4. Hearing loss study reveals role of bone hardness in tissue function
5. To prevent inbreeding, flowering plants have evolved multiple genes, research reveals
6. X-ray crystallography reveals structure of precursor to blood-clotting protein
7. Optical technique reveals unnexpected complexity in mammalian olfactory coding
8. Genomic comparison of ocean microbes reveals East-West divide in populations
9. Study reveals cancer-linked epigenetic effects of smoking
10. UW-built device reveals invisible world teeming with microscopic algae
11. Imaging reveals key metabolic factors of cannibalistic bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New microscope reveals ultrastructure of cells
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE ... collaboration catalyst that provides the connective tissue that enhances ... enabling them to easily share client-level information; earned a ... to expand to organizations serving seniors aging in community ... Diego" partner on December 11 th 4-6p. ...
(Date:12/10/2014)... , December 9, 2014 ... BCARD Platform   ... meeting scheduling solutions for business-to-business (B2B) events, today ... leader in mobile near-field communication (NFC), Bluetooth low ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... Centers for Disease Control and Prevention (CDC) found that ... age of menarche and total number of lifetime ovulatory ... the course of a woman,s lifetime may influence the ... study are published in Cancer Epidemiology, Biomarkers & ...
... new review article appearing in Environmental Health ... a research associate for the Project on Emerging ... for environmental cleanup. It provides an overview ... environment, health, and safety implications; and possible future ...
... history is filled with several turning points when temperatures ... came and disappeared. But one of the biggest moments ... roughly 540 million years ago, when complex, multi-cellular life ... scientists can pinpoint this pivotal period as leading to ...
Cached Biology News:2 reproductive factors are important predictors of death from ovarian cancer 22 reproductive factors are important predictors of death from ovarian cancer 3Contaminated site remediation: Are nanomaterials the answer? 2Explosive growth of life on Earth fueled by early greening of planet 2Explosive growth of life on Earth fueled by early greening of planet 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... March 17 Spiral Biotech, an Advanced Instruments ... Plating System -- which delivers faster cycle ... that boost processing speed and efficiency in microbiology ... (ASM) General Meeting in May, 2009."The introduction of ...
... Cardiorobotics, Inc., a medical device ... a wide range of applications, including: medical, industrial, ... Dr. Samuel Straface in the position of President ... Straface has joined Cardiorobotics in this executive leadership ...
... Novavax, Inc. (Nasdaq: NVAX ) today announced that ... a press release to be issued after 8:00 a.m. Eastern ... investor conference call to discuss its financial results at 10:00 ... be hosted by Novavax President and Chief Executive Officer Dr. ...
Cached Biology Technology:Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 2Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 3Cardiorobotics Announces New CEO, PLSG Executive-in-Residence to Lead Company 2Cardiorobotics Announces New CEO, PLSG Executive-in-Residence to Lead Company 3Novavax Announces Release Date of 2008 Fourth Quarter Financial Results and Investor Conference Call 2Novavax Announces Release Date of 2008 Fourth Quarter Financial Results and Investor Conference Call 3
... EPS 3501 XL Power Supply, 1. 3500 ... constant current, constant power, and linear voltage ... to focused equilibrium in IPG strips quickly ... compensate for variations in gel thickness, sample ...
...
Request Info...
... ESGRO Complete Derivation Kit is intended ... cells from delayed blastocysts in serum-free ... Clonal Grade ... Blastocyst Incubation Medium Trypsin Solution ...
Biology Products: