Navigation Links
New methods identify thousands of new DNA sequences missing from the human genome reference map
Date:4/20/2010

Along with their collaborators at Agilent, the team designed ways to examine these newly identified sequences in a panel of people representing populations from around the world. The researchers found that, in some cases, the number of copies of these sequences varied from person to person.

The fact that a person can have one or more copies, or no copy at all, of a particular DNA sequence may account for why these sequences were missing from the reference genome. The researchers also found that some of these sequences were common or rare in different populations, depending on from which part of the globe their ancestors originated.

"Each segment of the reference genome is from a single person, and reflects the genome of that individual. If the donor sample was missing a sequence that many other people have, that sequence would not be represented in the reference genome." Kidd explained. "That is why some of the positions on the reference genome represent rare structural configurations or entirely omit sequences found in the majority of people." Kidd said that the study published in Nature Methods used information from nine individuals, representing various world populations, to search for and fill in some of the missing pieces.

By looking at genomes from seven kinds of animals, the researchers were also able to show that some of the newly identified DNA sequences appear to have been conserved during the evolution of mammals and man. The animals whose genomes were studied were chimpanzee, Bornean orangutan, Rhesus monkey, house mouse, Norway rat, dog, and horse.

"Some of the sequences were present in several different species, but were absent from the reference genome," Kidd said. "Some of the sequences present in several mammals actually correspond to sites of variations in humans some people have retained a particular sequence, and others have lost it."

The researchers also developed a method to accurately
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New bioanalytical methods have potential for investigative and screening applications
2. A forensic analysis of Hurricane Katrinas impact: methods and findings
3. Biologists merge methods, results from different disciplines to find new meaning in old data
4. New management methods extend blackberry season
5. Widely used virus assay shown unreliable when compared to other methods
6. Magnetic nanotags spot cancer in mice earlier than methods now in clinical use
7. Company Granted Patent on Apparatus, Systems, and Methods for Gathering and Processing Wireless Biometric and Biomechanical Data
8. Cold Spring Harbor Protocols features RNA analysis methods
9. Researcher says microchannels could advance tissue engineering methods
10. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
11. Researchers develop brain-reading methods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... NY - July 24, 2014 -- Keryx Biopharmaceuticals, Inc. ... the long-term, randomized, active control Phase 3 study of ... phosphate binder, for the treatment of hyperphosphatemia in patients ... study (PhosphatE binding and iRon delivery with FErric CiTrate ... Journal of the American Society of Nephrology ( ...
(Date:7/24/2014)... on different species of fish, according to a ... Exeter which tested fish anti-predator behaviour. , ... predator model when exposed to additional noise, whereas ... , Lead author Dr Irene Voellmy of Bristol,s ... many aquatic environments have increased substantially during the ...
(Date:7/24/2014)... its own microbial terroir, meaning the microbial populations found ... the product, creating the final flavor according to research ... and Environmental Microbiology . This is the first time ... brewery. , Many sake makers inoculate with both ... of the University of California, Davis, but he and ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4The microbes make the sake brewery 2
... Researchers at Oregon State University have helped sequence ... for genetic improvements to related fruits like apples, peaches ... the journal Nature Genetics . "This will ... commercial strawberries," said OSU plant molecular biologist Todd Mockler, ...
... international research consortium has sequenced the genome of the ... Dec. 26 advance online edition of the journal ... possibilities for breeding tastier, hardier varieties of the berry ... the strawberry parts list," said the consortium,s leader Kevin ...
... brain tumours in larvae of the fruit fly Drosophila ... grow. The removal of some of these genes leads to ... for tumour development. The study, headed by ICREA researcher Cayetano ... . One of the characteristics of tumour cells ...
Cached Biology News:OSU helps decode strawberry genome in bid to improve fruit 2OSU helps decode strawberry genome in bid to improve fruit 3Georgia Tech team helps decode newly sequenced strawberry genome 2Georgia Tech team helps decode newly sequenced strawberry genome 3Some brain tumors mimic the genetic program of germline cells 2
(Date:7/24/2014)... Calabasas, CA (PRWEB) July 24, 2014 ... advancing the Global Supply Chain of the biotech ... annual SCM Innovation Awards, brought to you by ... premiere global organization of supply chain management professionals ... be given to stakeholders of the Biotech industry ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
(Date:7/24/2014)... natural and synthetic processes prefer to settle into ... energyit is within the realm of non-equilibrium conditions ... changes in energy and phases, such as temperature ... allow humans to regulate their body temperature, airplanes ... seismic activity. , But even though these ...
(Date:7/24/2014)... , July 24, 2014 SRI International ... with the National Institute of Allergy and Infectious Diseases ... conduct preclinical development of potential therapies for HIV infection ... to treat HIV and AIDS and the complications and ... microbicides for preventing sexual transmission of HIV. ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... Oct. 20 Prometheus Research LLC has formed the ... including dashboards and reports. The group will draw on ... of building custom biomedical data management applications. ... said Andrzej Pienczykowski, Executive Vice President for Product Development ...
... Incorporated (NYSE: DGX ), the world,s leading ... its Board of Directors increased the company,s share repurchase ... first three quarters of 2010, the company repurchased approximately ... fully utilizing its previous authorization, which was granted in ...
... OAK RIDGE, Tenn., Oct. 19, 2010 -- The Cold ... National Laboratory,s High Flux Isotope Reactor and a complementary ... entered its commissioning phase. The CTAX uses "cold" ... magnetic excitations in materials. Cold neutrons are slower than ...
Cached Biology Technology:Prometheus Research Launches Solutions Group to Springboard HTSQL-based Solutions for Customers 2ORNL's research reactor revamps veteran neutron scattering tool 2
dithiothreitol (DTT) Reactive Dyes and Chemicals Thiol-Reactive Dyes, Haptens and Quenchers Reducing Agents...
GRADIENT MAKER, 30 ML, 1 EA. Category: Protein Vertical Instruments....
Recombinant Rat Leptin, CF...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Biology Products: