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New method will triple amount of genetic information from newborn blood spot screenings
Date:1/12/2011

mation from blood on Guthrie cards using the least amount of this precious resource," said Resau.

"Showing that mRNA is reasonably well preserved in archived filter paper blood spots, whether frozen or not, opens up a very important avenue for clinical and translational research, especially in child health, because the largest such archive is samples used for newborn genetic screening," said Nigel Paneth, M.D., M.P.H., University Distinguished Professor in the Departments of Epidemiology and Pediatrics & Human Development at the Michigan State University College of Human Medicine.

Messenger ribonucleic acid or mRNA is a molecule that carries instructions from DNA to protein making structures in cells.

Since archived blood spots can be more than 20 years old, the researchers' next step is to investigate the power of activated gene detection in various archival periods. Resau said the cards could also be used for population studies, such as finding out when a particular virus first appeared in a specific region, or levels of compounds in that region that could be affecting public health.


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Contact: Joe Gavan
joe.gavan@vai.org
Van Andel Research Institute
Source:Eurekalert

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