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New method sneaks drugs into cancer cells before triggering release
Date:5/9/2014

es create an opening in the endosome, spilling their Dox-rich contents into the surrounding cell leading to cell death.

In a mouse model, the researchers found that the new technique significantly decreased the size of breast cancer tumors compared to treatment that used Dox without the nanoscale liposomes.

"This work is somewhat similar to previous research we've done with polymer-based nanogels but there is a key difference," says Dr. Zhen Gu, senior author of the paper and an assistant professor in the joint biomedical engineering program. "The difference is that this liposome-based technique allows us to introduce additional ATP into the cancer cell, releasing the drug more quickly.

"Being able to adjust ATP levels is important because some cancer cells are ATP deficient," Gu adds. "But this technique would work even in those environments."


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Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

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