Navigation Links
New method sneaks drugs into cancer cells before triggering release

Biomedical engineering researchers have developed an anti-cancer drug delivery method that essentially smuggles the drug into a cancer cell before triggering its release. The method can be likened to keeping a cancer-killing bomb and its detonator separate until they are inside a cancer cell, where they then combine to destroy the cell.

"This is an efficient, fast-acting way of delivering drugs to cancer cells and triggering cell death," says Dr. Ran Mo, lead author of a paper on the work and a postdoctoral researcher in the joint biomedical engineering program at North Carolina State University and the University of North Carolina at Chapel Hill. "We also used lipid-based nanocapsules that are already in use for clinical applications, making it closer to use in the real world."

The technique uses nanoscale lipid-based capsules, or liposomes, to deliver both the drug and the release mechanism into cancer cells. One set of liposomes contains adenosine-5'-triphosphate (ATP), the so-called "energy molecule." A second set of liposomes contains an anti-cancer drug called doxorubicin (Dox) that is embedded in a complex of DNA molecules. When the DNA molecules come into contact with high levels of ATP, they unfold and release the Dox. The surface of the liposomes is integrated with positively charged lipids or peptides, which act as corkscrews to introduce the liposomes into cancer cells.

As the liposomes are absorbed into a cancer cell, they are sealed off from the rest of the cell in an endosome a compartment that walls off all foreign material that gets into a cell.

The environment inside an endosome is acidic, which causes the Dox liposomes and ATP liposomes to fuse together, as well as to the wall of the endosome itself.

Meanwhile, two other things are happening simultaneously. First, the ATP liposomes spill their ATP into the Dox liposomes, releasing the Dox from its DNA cage. Second, the walls of the Dox liposomes create an opening in the endosome, spilling their Dox-rich contents into the surrounding cell leading to cell death.

In a mouse model, the researchers found that the new technique significantly decreased the size of breast cancer tumors compared to treatment that used Dox without the nanoscale liposomes.

"This work is somewhat similar to previous research we've done with polymer-based nanogels but there is a key difference," says Dr. Zhen Gu, senior author of the paper and an assistant professor in the joint biomedical engineering program. "The difference is that this liposome-based technique allows us to introduce additional ATP into the cancer cell, releasing the drug more quickly.

"Being able to adjust ATP levels is important because some cancer cells are ATP deficient," Gu adds. "But this technique would work even in those environments."


Contact: Matt Shipman
North Carolina State University

Related biology news :

1. Simulating in tiny steps gave birth to long-sought-after method
2. Computational method dramatically speeds up estimates of gene expression
3. New method isolates immune cells for researchers to study how they ward off oral diseases
4. New method confirms humans and Neandertals interbred
5. Gauging the impact of tropical forest logging: Winrock develops new method for quantifying carbon emissions
6. Research method integrates meditation, science
7. Faster genetic testing method will likely transform care for patients with breast cancer
8. New method yields potent, renewable human stem cells with promising therapeutic properties
9. A non-invasive, rapid screening method for Alzheimers disease
10. AZTI-Tecnalia develops a methodology for authenticating canned tuna species within 24 hours
11. Researchers warn against abrupt stop to geoengineering method
Post Your Comments:
Related Image:
New method sneaks drugs into cancer cells before triggering release
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
(Date:10/27/2015)... , Oct. 27, 2015 In the present ... of concern for various industry verticals such as banking, ... to the growing demand for secure & simplified access ... ,sectors, such as hacking of bank accounts, misuse of ... equipment such as PC,s, laptops, and smartphones are expected ...
(Date:10/26/2015)... LAS VEGAS , Oct. 26, 2015 ... an innovator in modern authentication and a founding member ... launch of its latest version of the Nok Nok™ ... to use standards-based authentication that supports existing and emerging ... Suite is ideal for organizations deploying customer-facing applications that ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 HemoShear Therapeutics, ... discovering drugs for metabolic disorders, announced today the ... its Board of Directors (BOD). Mr. Watkins is ... Human Genome Sciences (HGS), and also served as ... Jim Powers , Chairman and CEO of ...
(Date:11/24/2015)... , November 24, 2015 , ... in a European healthcare ... the companies will work closely together in identifying European breakthrough ... medical need. The collaboration is underpinned by a significant investment ... This is the first investment by Bristol-Myers Squibb in a ...
(Date:11/24/2015)... According to two new studies, fewer men are ... that many doctors, scientists, and public health experts have been ... PSA tests being done, will there be more men dying ... Samadi, "Despite the efforts made in regards to early ... cancer cause of death in men, killing approximately 27,500 men ...
(Date:11/23/2015)... THOUSAND OAKS, Calif., Nov. 23, 2015   Ceres, ... company, announced today financial results for the fiscal year ... its business. --> --> ... on commercializing forage and feed products with a better ... the company signed distribution agreements with several leading crop ...
Breaking Biology Technology: