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New method provides researchers with efficient tool for tagging proteins
Date:7/29/2014

rotein beforehand. In other words, it is possible to tag natural proteins, including antibodies.

The researchers use a piece of DNA that is engineered to bind to metal ions. Using this 'control stick', they direct another piece of DNA to a metal binding site on the protein, where it reacts. A considerable number of proteins bind metal ions, which makes them suitable for this method. A significant point in using this method is that the tagged proteins retain their functionality after being bound to DNA.

The researchers are applying for a patent for the new method, which has potential in a number of areas.

"Of greatest importance is the fact that we can use our technique for tagging antibodies. Antibodies that are chemically bound (conjugated) to chemotherapeutics represent an entirely new class of medicine in which the antibody part is used to recognise specific tissue and the chemotherapeutic part is used to kill the cell. When you tag antibodies, it's important that you keep the recognition element of the antibody intact. With our method, we strike the constant part of the antibody and not the variable part, which contains its recognition element. Our technique is therefore general for a major class of proteins," explains Anne Louise Bank Kodal, CDNA, another author of the article.


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Contact: Christian B. Rosen
crosen@chem.au.dk
Aarhus University
Source:Eurekalert

Page: 1 2

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