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New method provides researchers with efficient tool for tagging proteins
Date:7/29/2014

Aarhus University researchers have developed an easier method to create DNAprotein conjugates. The method can potentially strengthen the work involved in diagnosing diseases.

DNA linked to proteins including antibodies provides a strong partnership that can be used in diagnostic techniques, nanotechnology and other disciplines. DNAprotein conjugates which tag proteins with DNA can be used for purposes such as the sensitive detection and visualisation of biological material. The method also provides easier access to handling proteins in nanotechnology, where the DNA acts as a handle on the protein.

Controlling the conjugation of macromolecules such as DNA and proteins can be quite a challenge when scientists want to join them in particular ways and places. Researchers at Aarhus University have now developed a new and efficient method to tag proteins with DNA, making it much simpler to control the process than previously. The new method was developed at the Danish National Research Foundation's Centre for DNA Nanotechnology (CDNA) in collaboration between researchers at Aarhus University's Interdisciplinary Nanoscience Centre (iNANO), Department of Chemistry and Department of Molecular Biology and Genetics. The work is described in the highly prestigious scientific journal Nature Chemistry.

"Maintaining the protein's function and activity often requires the attachment of only a single DNA strand to the protein. At the same time, it can be important to know where the DNA strand is attached to the protein. You can normally only achieve this if you are working with genetically engineered proteins. This is a time-consuming and technically challenging process," explains PhD student Christian B. Rosen, CDNA, Aarhus University one of the researchers behind the new method.

The new method makes it possible to direct the tagging of proteins with DNA to a particular site on the protein, without genetically modifying the p
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Contact: Christian B. Rosen
crosen@chem.au.dk
Aarhus University
Source:Eurekalert

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