Navigation Links
New method of DNA editing allows synthetic biologists to unlock secrets of a bacterial genome
Date:12/5/2013

m Streptomyces griseus, a species of soil bacterium. They added a promoter before each gene in the cluster to increase expression, and inserted the cluster into a related bacterial species, Streptomyces lividans, that is easier to grow in a laboratory setting.

The resulting bacterial strain expressed all the genes in the previously silent cluster, and produced several previously unknown compounds. These compounds belonged to a class of natural products called polycyclic tetramate macrolactams or PTMs, many of which have useful biomedical applications. By examining the compounds produced by strains missing one of the six genes in the cluster, the researchers were able to discover the function of each gene's encoded protein, leading to a better understanding of how bacteria synthesize PTMs.

Zhao sees the work as an important step toward a larger goal: to create a generalized, automated high-throughput method to reconstruct any biochemical pathway in a target experimental organism. Zhao is the leader of the recently formed Biosystems Design Research Theme at the Institute for Genomic Biology, University of Illinois, and development of this type of method is a major goal of the Theme.

"We want the technology platform established, then we can actually work on mammalian systems, on plant systems, on microorganisms," said Zhao. Yet his ultimate motivation is the discovery of potentially useful biochemicals: "It's very likely some of the compounds will turn into new drugs, and that's very exciting."


'/>"/>

Contact: Nicholas Vasi
nvasi@illinois.edu
Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New method for stabilizing hemoglobin could lead to stable vaccines, artificial blood
2. SU biologist develops method for monitoring shipping noise in dolphin habitat
3. UCSB biomedical scientist discovers a new method to increase survival in sepsis
4. New method to diagnose sepsis is faster, cheaper
5. Rice University method gives accurate picture of gas storage by microscopic cages
6. MU study finds more accurate method to diagnose pancreatic cancer
7. New methods improve quagga and zebra mussel identification
8. Laser technology sorting method can improve Capsicum pepper seed quality
9. Researchers develop rapid, cost-effective early detection method for organ transplant injury
10. Scientists develop method that ensures safe research on deadly flu viruses
11. UTSA, Southwest Research Institute to develop low-cost method to treat fracking water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... Germany , June 17, 2015 ... QIA) today launched new Investigator ® STR assay kits ... the United States . The new genetic fingerprint ... genomic markers (short tandem repeats or STRs) for DNA matching. ... the quality of DNA in each sample, a novel QIAGEN ...
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - ... partnership centralized around the incorporation of handyem,s HPC-150 ... diagnostic laboratory, the Mo-POD™. This unprecedented model of ... International Conference at the Pennsylvania ... from June 15 th to 18 th ...
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... 2015 from previously communicated that it will amount to at ... 390 MSEK. Due to the rapid increase in market growth ... from the previously communicated guidance that revenue for 2015 will ... 2015 will amount to approximately 2,200 MSEK. Due ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... Nitrous oxide is a potent greenhouse gas and a ... the ozone. Intensively managed, grazed pastures are responsible for ... excrement. Biochar is potentially a mitigation option for reducing ... carbon can be sequestered in the soil. Biochar also ...
... 17, 2011 (BRONX, NY) Researchers at Albert ... that members of an enzyme family found in humans and ... in regulating cell motility. Their findings suggest an entirely new ... cancer. , David Sharp, Ph.D. , associate professor of ...
... now lives in cities, yet we know little about how ... kind, ecologists in Indianapolis, USA have used 70 year-old dried ... plants. The results are published this week in the British ... Dr Rebecca Dolan, director of the Friesner Herbarium, Butler University, ...
Cached Biology News:Can biochar help suppress greenhouse gases? 2Enzyme can steer cells or possibly stop them in their tracks 2Ecologists use 70-year-old pressed plants to chart city's vanishing native flora 2
(Date:6/30/2015)... 30, 2015  Custom Computer Specialists, Inc. ("Custom"), a ... are silver sponsors of the Primary Care Development Corporation,s ... is lending their support of PCDC,s mission to expand ... Since its founding in 1993, PCDC has been a ...  PCDC has financed over 100 completed primary care projects, ...
(Date:6/30/2015)... ... 30, 2015 , ... Southern Illinois University Edwardsville Chancellor Julie ... president of instruction at Chippewa Valley Technical College (CVTC) and will assume her ... lead SIUE during the past three years,” Furst-Bowe said. “I want to thank ...
(Date:6/29/2015)... ... June 30, 2015 , ... This cutting edge standard making ... Featuring 12 distinct peaks, the WAV-8 is the world’s first cuvette-shaped, solid-state filter ... deep into the NIR range. Previous spectrophotometer calibration standards, such as those made from ...
(Date:6/29/2015)... ... ... The global microfluidics market is expected to grow at ... The market is mainly driven by the rising geriatric population, growing Asian healthcare ... adequate healthcare and research infrastructure in emerging markets, dearth of skilled professionals in ...
Breaking Biology Technology:Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5
... (USP) Convention,an official public standards-setting authority for all ... on December 4, 2008,transferred all rights, ownership and ... This announcement comes one year after Quantros,and ... all,operations, support, marketing and sales for the MEDMARX ...
... magazine profiles the best up-and-coming young investigators, selected by the ... NEW YORK, Dec. 8 Genome Technology magazine has named ... "Tomorrow,s PIs" special edition. , , ... biological research through the eyes of some of the best ...
... COUNTY, Calif., Dec. 8 Beckman Coulter,Inc. (NYSE: ... simplify, automate, and innovate complex biomedical tests, will host its,Annual ... December 16,2008, from 9:00 a.m. to 12:00 p.m. (ET). , ... ) , The live ...
Cached Biology Technology:Quantros Acquires MEDMARX(R) from United States Pharmacopeia (USP) 2Quantros Acquires MEDMARX(R) from United States Pharmacopeia (USP) 3Quantros Acquires MEDMARX(R) from United States Pharmacopeia (USP) 4Genome Technology Names 2008 'Tomorrow's PIs' 2Genome Technology Names 2008 'Tomorrow's PIs' 3Genome Technology Names 2008 'Tomorrow's PIs' 4
... White crystalline solid. PACKAGED UNDER ... Contaminants: DNases, proteases, RNases: none ... nm): ≤0.500; (100 mM, 1 cm, 280 ... Soluble in H 2 O. RTECS ...
... Genome ChIP-on-chip Microarray is specifically designed ... cerevisiae) DNA binding proteins by pairing ... microarrays. This set delivers robust hybridization ... true binding events and fewer false ...
... Salmonella genomes has allowed the development of ... pairs. The S. enterica Typhimurium (strain LT2) ... bp; 4,440 ORFs) and a plasmid, pSLT ... Sigma-Genosys have been designed to amplify all ...
... productivity and allows you to achieve a higher ... beyond traditional paper-based weighing processes into a powerful ... Control of ... PR, SR, PG-S, PG, SG, AT, MT, UMT, ...
Biology Products: