Navigation Links
New method monitors early sign of oxidative stress in cancer
Date:9/11/2009

.

The researchers then used the method to assess sulfenic acid levels as a marker of oxidative stress in several systems, including a panel of breast cancer cell lines.

"For each line, we saw a very distinct pattern of sulfenic acid modifications," indicating different oxidative stress levels and hinting at differences in the underlying molecular events associated with tumor growth," said Carroll, assistant professor of chemistry and a research assistant professor in the Life Sciences Institute. "Whether the patterns we see will correlate with response to antioxidant treatment or other therapies that modulate oxidative stress level remains to be seen, but now we at least have a way to investigate that question."

Next, Carroll's group wants to determine which specific proteins in the cell are being modified and what roles, if any, those proteins play in the disease process. "Some of the modified proteins may not play any role, but I'm sure it will turn out that many of them do," Carroll said. "Once we find out which proteins are involved, we can target them directly rather than using global treatments like antioxidants."

The U-M Office of Technology Transfer is working on commercialization of the technology. Patent protection has been applied for, and the compounds used in this research soon will be commercially available.


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Prototype NIST method detects and measures elusive hazards
2. Researcher says microchannels could advance tissue engineering methods
3. Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
4. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
5. Researchers develop brain-reading methods
6. NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
7. New biomarker method could increase the number of diagnostic tests for cancer
8. Energy-saving method checks refrigerant level in air conditioners
9. Improved method developed to test carcinogen risk
10. Infant formula adulteration with melamine underscores need for better detection methods
11. UBC researchers develop new method to study gambling addictions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... , June 17, 2015 QIAGEN ... launched new Investigator ® STR assay kits for analysis ... United States . The new genetic fingerprint kits provide ... (short tandem repeats or STRs) for DNA matching. They incorporate ... of DNA in each sample, a novel QIAGEN technology that ...
(Date:6/16/2015)... CITY , June 16, 2015 /CNW Telbec/ ... their partnership centralized around the incorporation of handyem,s ... point-of-care diagnostic laboratory, the Mo-POD™. This unprecedented model ... BIO International Conference at the Pennsylvania ... from June 15 th to 18 ...
(Date:6/16/2015)... 2015 Fingerprint Cards (FPC) raises the ... will amount to at least 340 MSEK to that it ... increase in market growth and orders received the revenue guidance ... revenue for 2015 will exceed 1,500 MSEK to an updated ... MSEK. Due to receipt of orders of touch ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... (TUM) have formed a strategic alliance for catalysis research, "Munich ... catalysis, a major aspect of this cooperation will be the ... meet the rising global demand for energy and base chemicals ... work with up to two million euros a year. The ...
... extinction of dinosaurs 65 million years ago paved the way ... bigger than they had been. The study, released ... first to quantitatively explore the patterns of body size of ... funded by a National Science Foundation Research Coordination Network grant, ...
... are overexposed to antibacterial soaps containing triclosan may suffer ... A among adults may negatively influence the immune system, ... study suggests. Triclosan is a chemical compound widely ... diaper bags and medical devices. Bisphenol A (BPA) is ...
Cached Biology News:Up to 20 million euros for Munich Catalysis research cooperation 2Up to 20 million euros for Munich Catalysis research cooperation 3Researcher explores the evolution of largest mammals over the past 100 million years 2Study suggests that being too clean can make people sick 2
(Date:7/3/2015)... ... July 03, 2015 , ... ... products for use in applications such as animal waste reduction, bioremediation, wastewater ... and restaurant kitchen settings, announced today that it will be showcasing, ManureMagic™, ...
(Date:7/3/2015)... Houston, Texas (PRWEB) , ... July 03, 2015 ... ... search firm, highly-regarded by Fortune 500 companies and professional service industries alike-- typically ... aimed to make clients laugh, honor a good cause and break from their ...
(Date:7/3/2015)... July 3, 2015 ... september 2015 på  http://www.openinnovationinscience.at till det ... Science" som hålls i Wien ... undersökning med internationella forskare och vetenskapsmän som ... hälsovetenskapens två största utmaningar bristen på incitament ...
(Date:7/3/2015)... July 3, 2015  Pomerantz LLP announces that a ... Inc. ("Puma" or the "Company")(NYSE: PBYI ) and ... United States District Court, Central District of ... behalf of a class consisting of all persons or ... and May 13, 2015 inclusive (the "Class Period").  This ...
Breaking Biology Technology:DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2The Alexander Group Declares Their Independence with a Bit of Levity 2Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4
... scientists are harnessing nanotechnology to quickly produce ultra-lightweight, ... everyday paper. Simply coating a sheet of ... silver nanowires makes a highly conductive storage device, ... and engineering. "Society really needs a low-cost, ...
... , , MONTREAL, Dec. 7 ... wholly-owned U.S. affiliate, has been selected by the U.S. Department ... the construction and operation of its waste-to-biofuels facility to be ... only four that have been selected in the larger demonstration ...
... , PRINCETON, N.J., Dec. 7 PharmaNet ... services to pharmaceutical, biotechnology, generic drug and medical device ... Company as Chief Information Officer. , In his ... corporate information technology function including strategy development and execution ...
Cached Biology Technology:Dip ordinary paper into ink infused with nanotubes and nanowires to create an instant battery 2Enerkem Awarded $50 Million Funding by U.S. Department of Energy for its Mississippi Biorefinery Project 2Enerkem Awarded $50 Million Funding by U.S. Department of Energy for its Mississippi Biorefinery Project 3Stephen Kasay Joins PharmaNet Development Group as Chief Information Officer 2
... ALH 3000 workstation automates a wide array ... and Proteomic Sample Preparation to Bio-Molecular and ... design of the Caliper Sciclone enables numerous ... perfectly meet the needs of a given ...
Designed for use with the Agencourt SprintPrep 384 kit and all MCPrep reagent kits. Used with flat bottom 96-well microplates such as deep well plates used to culture bacteria....
... TRAC is a platform for fully ... applications. It can easily be configured for ... to molecular biology.TRAC allows closed loop screening, ... screen, hit list generating, cherry picking and ...
... devices for the fast and reliable clarification/filtration of ... 500 l. They can be used in fixed ... Features: High-flux Polyethersulphonemembrane 0.8 ... volume ( Fast and reproducible performance ...
Biology Products: