Navigation Links
New method isolates immune cells for researchers to study how they ward off oral diseases
Date:4/15/2014

Case Western Reserve University dental researchers have found a less invasive way to extract single rare immune cells from the mouth to study how the mouth's natural defenses ward off infection and inflammation.

By isolating some specialized immune cells (white blood cells known as "leukocytes") to study how they fight diseases in the mouthor reject foreign tissues, such as in failed organ transplantsresearchers hope to learn more about treating and preventing such health issues as oral cancers, cardiovascular disease, AIDS and other infectious diseases.

To this point, researchers have had to rely on studying and growing immune cells from blood. Studying tissue immune cells allows researchers to learn how they function at the site of infection.

The role of adaptive immune cells in the stomach and intestines is more widely known, yet the role of similar cells in the mouth is unclear. There are no reliable methods to extract immune cells from mouth, which are more accessible and easier to extract than harder-to-reach tissues in the stomach and intestines.

But, until now, immune cells removed from the mouth couldn't be isolated with enough viability or grown to study their activities, Pushpa Pandiyan, assistant professor of biological sciences at the dental school, explained.

The new method, developed by Pandiyan, the study's lead author, is described in Biological Procedures article, "Isolation of T cells from mouse oral tissues."

Pandiyan, who studies oral diseases associated with HIV, found no reliable method existed to isolate and keep a single cell from the tongue, gums and palate alive long enough to study.

Pandiyan and her team developed a way to do so successfully. The researchers reported that more than 94 percent of the isolated cells lived long enough to study.

Their method

Using mouse models, the researchers isolated two important specialized immune T lym
'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New method confirms humans and Neandertals interbred
2. Gauging the impact of tropical forest logging: Winrock develops new method for quantifying carbon emissions
3. Research method integrates meditation, science
4. Faster genetic testing method will likely transform care for patients with breast cancer
5. New method yields potent, renewable human stem cells with promising therapeutic properties
6. A non-invasive, rapid screening method for Alzheimers disease
7. AZTI-Tecnalia develops a methodology for authenticating canned tuna species within 24 hours
8. Researchers warn against abrupt stop to geoengineering method
9. New NIST method evaluates response to oxidation in live cells
10. Caltech-developed method for delivering HIV-fighting antibodies proven even more promising
11. New method developed for ranking disease-causal mutations within whole genome sequences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... as simple as inserting a medicated, disappearing fabric minutes ... have discovered a potentially faster way to deliver a ... method spins the drug into silk-like fibers that quickly ... of the drug than possible with other topical materials ... women a potentially more effective, discreet way to protect ...
(Date:7/30/2014)... colors, nature had already perfected the process think ... example. Now scientists are tapping into those secrets to ... plastics. Their paper on using structure or the ... to produce color appears in the ACS journal ... and colleagues point out that currently, plastic manufacturers add ...
(Date:7/30/2014)... has been awarded the Scientific Committee on Antarctic ... Research. , SCAR, an inter-disciplinary international science body, ... research in the Antarctic region, and on the ... system. The organisation also provides scientific advice about ... governing the region. , The medal is open ...
Breaking Biology News(10 mins):Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... a trait which could be exploited in lands affected by ... the Society for Experimental Biology meeting on July 5, shows ... outer layer of their roots are more efficient at accessing ... Jonathan Lynch at the Pennsylvania State University, United States, found ...
... ITHACA, N.Y. With fewer than a dozen flowering plants ... caloric intake, people need to tap unused plants to feed ... geneticist Susan McCouch in the Comment feature of the July ... with population growth and rising incomes around the world, researchers ...
... TORONTO - A team of Toronto-based researchers may be one ... cells for use in research and therapy. Induced pluripotent ... research because they can flexibly develop into many different types ... proteins that control their generation are largely unknown. But ...
Cached Biology News:To feed the future, we must mine the wealth of the world's seed banks today 2Toronto team ID proteins key in stem cell production 2
(Date:7/30/2014)... 2014 A study presented at the ... efficacy of CSL Behring,s C1 Inhibitor (C1-INH) concentrate ... highly sensitized patients. C1-INH is a human protein ... The study shows that post-transplant treatment ... levels of complement components 3 and 4, suggesting ...
(Date:7/30/2014)... AZ (PRWEB) July 30, 2014 Sales ... the launch of blended sales training programs for companies ... sales training programs used by thousands of salespeople over ... blended sales training program can be customized to address ... , The blended sales training program consists ...
(Date:7/30/2014)... PA (PRWEB) July 30, 2014 Vycom ... family of products, designed to meet Factory Mutual (FM) ... equipment materials such as wet benches, process tools, fume ... worker safety and damage to semiconductor wafers used in ... provides a flame-retardant PVC solution with excellent workability and ...
(Date:7/30/2014)... July 30, 2014   Epic Sciences, Inc. ... novel diagnostics to personalize and advance the treatment and ... Gregory T. Lucier as chairman of Epic,s board ... of Life Technologies (formerly Invitrogen). Mr. Lucier joins Epic,s ... its circulating rare cell analysis platform with special focus ...
Breaking Biology Technology:Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 2Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 3Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3
... Jan. 19 /PRNewswire-FirstCall/ - ConjuChem Biotechnologies, Inc. (TSX: CJB) ... independent Board members to explore and evaluate all strategic alternatives ... or the sale of all or a substantial part of ... external consultants to expeditiously make recommendations as to the optimal ...
... Using ... Not Quantity , ... Chicago, IL (PRWeb) January 19, 2010-- Ocean Tomo, LLC, the Chicago-based Intellectual Capital Merchant ... , , , ,The study, which ranks the 25 companies with the Most ...
... , , BIRMINGHAM, Ala. , Jan. ... "bad boy" when it comes to cholesterol. According to a new ... little A" — can be labeled "bad cholesterol." The landmark study ... recently published in the New England Journal Of Medicine ...
Cached Biology Technology:ConjuChem to evaluate strategic alternatives 2Ocean Tomo Study Ranks Top 25 Most Inventive Companies for Bloomberg BusinessWeek, 2Ocean Tomo Study Ranks Top 25 Most Inventive Companies for Bloomberg BusinessWeek, 3Ocean Tomo Study Ranks Top 25 Most Inventive Companies for Bloomberg BusinessWeek, 4New Study: Lp(a) Joins LDL as Heart Disease Risk Factor 2New Study: Lp(a) Joins LDL as Heart Disease Risk Factor 3