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New method for stabilizing hemoglobin could lead to stable vaccines, artificial blood
Date:12/3/2013

A UConn research team has found a way to stabilize hemoglobin, the oxygen carrier protein in the blood, a discovery that could lead to the development of stable vaccines and affordable artificial blood substitutes.

The team's novel approach involves wrapping the polymer poly(acrylic acid) around hemoglobin, protecting it from the intense heat used in sterilization and allowing it to maintain its biological function and structural integrity.

In addition to having potential applications in the stabilization of vaccines and development of inexpensive artificial blood, the stabilizing polymer also allows vaccines and other biomedical products to be stored for longer periods without refrigeration. It could also have applications in biomaterials, biosensors and biofuels.

"Protein stability is a major issue in biotechnology," says Challa V. Kumar, UConn professor of chemistry and biochemistry and the primary investigator on the project. "What we've done is taken this protein molecule and wrapped it up in a polymer chain in order to stabilize it. In thermodynamics terms, we have restricted the entropy of the denatured state of the protein and stabilized it beyond our expectations. The system also exhibits a high degree of reversibility. The protein can be denatured and renatured many, many times. This is the very first example of its kind in the literature of all protein science. No one has ever been able to achieve this kind of stability for proteins."

A popular example of denaturation can be found in the protein present in eggs. As the egg is cooked and the protein around the yolk turns white, the protein in the egg is denatured and cannot return to its prior, natural state. Likewise, when proteins in a living cell are exposed to heat they become denatured, which disrupts their activity and can lead to cell death. When protein is a critical element in a vaccine and breaks down, the product becomes useless.

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Contact: Challa V. Kumar
challa.kumar@uconn.edu
860-486-3213
University of Connecticut
Source:Eurekalert  

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