Navigation Links
New method for safer dosing of anticoagulants

Elderly people with atrial fibrillation are often treated with anticoagulants to thin the blood, but this medicine is hard to dose and patients have to have their blood tested regularly. Researchers at the Sahlgrenska Academy at the University of Gothenburg and Chalmers University of Technology have now devised a new method that improves the accuracy of risk assessments.

Atrial fibrillation, or irregular heartbeat, is a very common heart rhythm disturbance that increases the risk of stroke and death. It is usually treated with warfarin, where the dose is calculated by measuring the coagulation of the blood. The dose is increased if coagulation is too quick, and decreased if it is too slow. Patients with unsatisfactory samples are tested more frequently, while satisfactory samples mean that the test interval can be extended.

New measurement method more reliable

In a study involving 20,000 patients in Sweden, Marcus Lind, postdoctoral researcher at the University of Gothenburg's Sahlgrenska Academy and consultant at the NU group of hospitals, tested a new measurement method that assesses far more reliably who is at risk of serious complications and admission to hospital.

"Our method takes account of how blood viscosity goes up and down," says Lind. "This meant that we could establish far more reliably which patients were at risk of a stroke, haemorrhaging or dying."

Collaboration with Chalmers

The new method also takes account of the values' extremes. "In the past we've only checked whether patients fall within the therapeutic range but the new method allows us to identify more accurately how coagulation varies both within and beyond this range," says Anders Odn, professor of biostatistics at Chalmers University of Technology, who played a key role in developing the new method.

Reduces risks

The new method improves the chances of understanding which patients are at risk of complications, and is therefore an indicator for stepping up checks and probably reducing the risks.

"This is also important given the current debate about switching some patients who don't settle on warfarin to a different kind of medication," says Lind. "The new method pinpoints these patients more accurately."

Contact: Marcus Lind
University of Gothenburg

Related biology news :

1. Scalable amounts of liver and pancreas precursor cells created using new stem cell production method
2. Methods in Enzymology celebrates its 500th volume
3. New method of growing high-quality graphene promising for next-gen technology
4. Method of studying roots rarely used in wetlands improves ecosystem research
5. New method cleans up textile industrys most dangerous chemicals
6. MU researchers unveil new method for detecting lung cancer in Nature article
7. Human Gene Therapy expands with robust new methods journal
8. UH researchers work to develop screening method for superbug
9. Rice unveils new method to grow synthetic collagen
10. Novel method for increasing antibiotic yields
11. New imaging method sheds light on cell growth
Post Your Comments:
Related Image:
New method for safer dosing of anticoagulants
(Date:9/29/2015)...  iDAvatars is excited to be named one of the ... The official announcement was recently made at an invite-only ... San Francisco , where iDAvatars presented a demo ... "It is both an honor and a privilege ... to market the cognitive power of IBM Watson in our ...
(Date:9/28/2015)... -- The global image sensors market ... by 2020, growing at a CAGR of 4.6% from ... (BSI) technique to improve picture quality are expected to ...      (Logo: , The light falls ... and, thus, reduce the noise interference and increase picture ...
(Date:9/26/2015)... , Sept. 26th, 2015  Results of ... will be unveiled today at the Stanford Medicine ... Engagement Using iPad Dashboards, Connected Health Devices and ... of Pharmacy 3.0, will explain how senior patients ... data to their pharmacist via the TactioRPM remote ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... the United States , Canada ... of all new cases of kidney cancer.   --> ... and Europe .  PRCC represents about 14% of ... China MediTech Limited ("Chi-Med") (AIM: HCM) today announces that Hutchison MediPharma ... have completed enrolment in a global Phase II study of savolitinib ...
(Date:10/12/2015)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), the leading ... processes to develop and market advanced products and therapies ... Ophthalmic, and the Dental sectors of healthcare, announced today ... the Company has been dismissed by the court.  ... stated, "As we suspected, this case was brought by ...
(Date:10/12/2015)... , October 12, 2015 cell surface ... billion by 2022, according to a new report by Grand ... to rise in incidence of oncology diseases and other cell-associated ... is expected to reach USD 6.49 billion by 2022, according ... growth in demand can be attributed to rise in incidence ...
(Date:10/12/2015)... SAN DIEGO , Oct. 12, 2015 /PRNewswire/ ... for debilitating allergic and inflammatory diseases and conditions, ... Series A preferred stock financing. Concurrent with the ... also entered into a Loan and Security Agreement ... borrow up to $7 million. Patara will use ...
Breaking Biology Technology: