Navigation Links
New method for researching understudied malaria-spreading mosquitoes
Date:2/28/2013

Researchers at the Johns Hopkins Malaria Research Institute have developed a new method for studying the complex molecular workings of Anopheles albimanus, an important but less studied spreader of human malaria. An. albimanus carries Plasmodium vivax, the primary cause of malaria in humans in South America and regions outside of Africa. Unlike Anopheles gambiae, the genome of the An. albimanus mosquito has not been sequenced and since these two species are evolutionarily divergent, the genome sequence of An. gambiae cannot serve as an appropriate reference. The researcher's findings were published online in the journal Molecular & Cellular Proteomics.

"Technologies and platforms are needed to bridge the scientific gaps that could eventually spur the development of novel interventions to combat all human malarias," said study author, Rhoel Dinglasan, PhD, MPH, an assistant professor with the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. "To our knowledge, no approaches have been published that address this issue."

For the study, Dinglasan and his colleagues developed a method to compare proteins of the midgut of An. albimanus and An. gambiae. The mosquito midgut is a critical stage in the lifecycle of the malaria parasite and in the transmission of malaria to people. For An. albimanus, the researchers developed a seamless, integrated transcriptomic-to-proteomic approach involving assembly of the An. albimanus midgut transcriptome followed by acquisition of the luminal midgut microvilli proteome.

Dinglasan added, "This comparative proteomic analysis of the midgut brush borders of two important malaria vectors, An. gambiae and An. albimanus, which we envision will be one of many comparative studies, will help researchers develop new mosquito-based targets for drugs, v
'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. New 3-D stem cell culture method published in JoVE
2. New methods for better purification of wastewater
3. More effective method of imaging proteins
4. New method for estimating parameters may boost biological models
5. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
6. Scientists discover new method of proton transfer
7. Oceanographers develop method for measuring the pace of life in deep sediments
8. Notre Dame researchers using novel method to combat malaria drug resistance
9. Rapid method of assembling new gene-editing tool could revolutionize genetic research
10. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
11. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
(Date:4/2/2015)... BETHESDA, Md. , April 2, 2015 ... Salt Lake City , the American ... election of five new directors to its Board.  Members ... for the ACMG and for forming and advancing its ... the medical genetics profession. "It,s an eventful ...
(Date:4/1/2015)... BOSTON , April 1, 2015   Medisafe ... 1.5 million users across iOS and ... has begun integrating biofeedback into the platform to allow ... health outcomes. For the first time, patients will be ... missing a dose impacts important biometrics, such as glucose ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... Jan. 26, 2012  Medbox, Inc. (Pinksheets: MDBX) ( ... products for 2012. Through their ... medicine dispensing and storage systems, which are designed ... centers, alternative medicine clinics and doctor,s offices. The ...
... RICHLAND, Wash. The Department of Energy,s Pacific ... a lab-developed technology that improves research sample analysis ... announced today that PNNL is receiving a 2012 ... is a nationwide network that encourages federal laboratories ...
... Hosted by the College of Agricultural Sciences, The Pennsylvania State ... Deadline for Abstract Submissions: 1 March 2012 -- The ... submit an abstract for presentation at the 45th SSR Annual ... 2012. Links to the following are to be found ...
Cached Biology News:Medbox, Inc. Announces New Product Line for 2012 2PNNL recognized for technology transfer 2
(Date:4/20/2015)... Whitehouse Laboratories is pleased and overly ... recent Food and Drug Administration (FDA) inspection and received ... day, GMP compliance inspection, as based upon 21CFR Parts ... April 6th and was granted NAI (no action indicated) ... strict Good Manufacturing Practice (GMP) quality system required by ...
(Date:4/17/2015)... Reed Technology and Information Services Inc. ... preparation, and submission to the U.S. Food and Drug ... Lot Distribution Report (LDR) service for manufacturers of biologics, ... the FDA’s new rule on electronic submission of LDRs. ... volume and timing of particular biologics introduced to the ...
(Date:4/17/2015)... NEW YORK , April 17, 2015  Guggenheim ... Guggenheim Partners, today announced the hiring of William ... research analyst. Mr. Tanner will start work ... New York office. "Bill ... and academic research, to our experienced and highly acclaimed ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 LC ... proteomics technologies, announced today that it is seeking ... an innovative multiplex PCR based targeted sequencing technology. ... sequence analysis, that enables accurate detection of rare ... and Omega-Primer™ technologies. The company will collaborate with ...
Breaking Biology Technology:Whitehouse Laboratories Completes FDA Inspection with No Form 483 – No Observations 2Whitehouse Laboratories Completes FDA Inspection with No Form 483 – No Observations 3Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3
... managed, with the help of an advanced X-ray flash, to ... that has been recognised by the journal Science . ... home to one of the world,s most advanced particle accelerators, ... and study life,s tiniest components: atoms, molecules and proteins. ...
... PLYMOUTH MEETING, Pa. , May 10 /PRNewswire-Asia-FirstCall/ -- ... announced,financial results for the first quarter ended March 31, 2010 . ... ... was a,quarter of successful management transition at Sunstone. We replaced senior,managers including ...
... Fla. , May 10 Dyadic International, Inc. ... today that its President and Chief Executive Officer, Mark ... Renshaw 6th Annual Global Healthcare Conference in London, England ... 11:05 a.m. local time ( 6:05 a.m. EDT ). ...
Cached Biology Technology:BMP Sunstone Reports First Quarter 2010 Financial Results 2BMP Sunstone Reports First Quarter 2010 Financial Results 3BMP Sunstone Reports First Quarter 2010 Financial Results 4BMP Sunstone Reports First Quarter 2010 Financial Results 5BMP Sunstone Reports First Quarter 2010 Financial Results 6BMP Sunstone Reports First Quarter 2010 Financial Results 7BMP Sunstone Reports First Quarter 2010 Financial Results 8BMP Sunstone Reports First Quarter 2010 Financial Results 9BMP Sunstone Reports First Quarter 2010 Financial Results 10BMP Sunstone Reports First Quarter 2010 Financial Results 11BMP Sunstone Reports First Quarter 2010 Financial Results 12Dyadic International to Present at Rodman & Renshaw 6th Annual Global Healthcare Conference 2
... Mouse monoclonal [E12] to MAP1 Light Chain ... mediate the physical interactions between microtubules and components ... of a heavy chain subunit and multiple light ... is one of the light chain subunits and ...
... alpha, also known as smooth muscle cell specific ... levels in various tissues such as intestine, lung ... regulatory protein, calponin. SM22 alpha expression has been ... in both vascular and visceral forms. It is ...
... pixel digital color camera plus overhead UV ... The cabinet features built-in overhead UV with ... on two sides of the cabinet for ... Interior overhead white light is included ...
Pendrin (H-195)...
Biology Products: