Navigation Links
New method for reducing tumorigenicity in induced pluripotent stem-cell based therapies
Date:7/23/2014

New Rochelle, NY -- The potential for clinical use of induced pluripotent stem cell (iPSC) technology for transplant-based therapeutic strategies has previously been hindered by the risk of dysregulated cell growth, specifically the development of tumors. The ability to use etoposide treatment to halt teratoma formation in iPSCs for the treatment of heart disease, specifically acute myocardial infarction, is demonstrated in an article in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Stem Cells and Development website.

In the article 'Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy' Saranya Wyles, Andre Terzic, Timothy Nelson, and coauthors, Mayo Clinic (Rochester, MN), discovered a strategy that alone or in conjunction with other methods could significantly reduce the risk of a tumorigenic event occurring. Their work demonstrates how pretreatment with genotoxic etoposide significantly lowered the threat of abnormal growths by removing the contaminated pluripotent cells and establishing an adjunctive therapy to further harness the clinical value of iPSC-derived cardiac regeneration.

"For anyone seeking to exploit iPSC technology in a clinical setting, the Mayo Clinic has described a strategy that significantly mitigates the risk of tumor development. Furthermore, the paper provides benchmark strategies for assessing the localization and persistence of cell-based treatments in a preclinical model," says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.


'/>"/>
Contact: Kathryn Ruehle
kruehle@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related biology news :

1. Novel methods may help stem cells survive transplantation into damaged tissues
2. Splice-switching oligonucleotide therapeutics is new method for editing gene transcript
3. A new genome editing method brings the possibility of gene therapies closer to reality
4. Food allergies: A new, simple method to track down allergens
5. Comparison study of planting methods shows drilling favorable for organic farming
6. Researchers discover Trojan Horse method of penetrating cellular walls without harm
7. Animal testing methods for endocrine disruptors should change, team argues
8. Frederic Bushman, Ph.D. receives Pioneer Award for advancing therapeutic gene delivery methods
9. Fungal infection control methods for lucky bamboo
10. New method of wormlike motion lets gels wiggle through water
11. Breakthrough method for making Janus or patchy capsules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New method for reducing tumorigenicity in induced pluripotent stem-cell based therapies
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 22, 2017 , ... RURO, Inc., a leading LIMS, RFID, ... content-packed update to the Limfinity® framework. , LimitLIS® and other RURO solutions based ... of customers among labs and other businesses. Limfinity® 6.5 adds new features and ...
(Date:6/20/2017)... , June 20, 2017  Kibow Biotech Inc., a ... announce the issuance of a new patent covering a ... by the U.S. Patent and Trademark Office on May ... of the Buzz of Bio award in 2014 in ... to developing non-drug approaches to chronic disease. Renadyl™, the ...
(Date:6/19/2017)... ... June 19, 2017 , ... ... clinical development reported today that it is launching two new additions of its ... be demonstrating new capabilities at the DIA 2017 Annual Meeting in Chicago, IL, ...
(Date:6/16/2017)... ... June 16, 2017 , ... CTNext , Connecticut’s ... Awards (EIA), held at The LOFT at Chelsea Piers in Stamford. , Nine finalists, ... a panel of judges for an opportunity to secure $10,000 awards to help support ...
Breaking Biology Technology: