Navigation Links
New medications show promise in treating drug-resistant prostate cancer
Date:4/7/2009

ress the growth of cancer cells temporarily, but in most patients the cancer ultimately develops resistance to drugs. About 29,000 men in the United States die each year from the disease.

Prostate cancer becomes resistant to antiandrogen drugs when cancer cells begin to increase production of the androgen receptor, said Sawyers. When the level of androgen receptors on the cells' surface reaches a certain level, the drugs that originally suppressed the cancer actually begin to stimulate cancer growth.

Because of this backlash effect, many scientists have questioned whether blocking the androgen receptor is a wise course of action. But Sawyers and his colleagues believe that blocking the receptor is critical to successful treatment. So they set out to design a new generation of drugs that can block the androgen receptor without unwanted side effects, even when levels of the receptor are high.

Researchers in Sawyers' lab based their designs on a drug that tightly attaches to the site on the androgen receptor that binds testosterone. If that site is blocked, the hormone cannot bind to prostate cells and tell the receptor to stimulate growth. Using this molecule as a chemical scaffold, the researchers synthesized nearly 200 slightly different versions of the drug. They tested each one in the lab on prostate cancer cells that had been engineered to produce high levels of androgen receptor.

This screening yielded two molecules, RD162 and MDV3100, which tightly bind to the androgen receptor and did not show the cancer-stimulating effect of bicalutamide and other current antiandrogen drugs. The molecules were good candidates for drugs, because they are readily absorbed into the blood when taken orally and they persist in the bloodstream.

The researchers tested the new drugs' effectiveness in mice with tumors derived from drug-resistant prostate cancer cells. "To our delight, we found that these compounds caused very dramatic shrinkage of tumors in th
'/>"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Device prevents potential errors in childrens medications
2. Study of successful drug targets could hasten development of new medications
3. Genetic variant mimics effect of heart failure medications
4. Hypertension and cholesterol medications present in water released into the St. Lawrence River
5. Innovative civil engineering application promises cleaner waters
6. New CPR promises better results by compressing abdomen, not Chest
7. Tiny tubes and rods show promise as catalysts, sunscreen
8. New genetic research into nicotine addiction shows promise for personalized treatment
9. Genetic ancestral testing cannot deliver on its promise, study warns
10. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
11. Summer-dormant tall fescue grass shows promise for pasture improvements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... NEW YORK , Nov. 18, 2014 /PRNewswire/ ... iris-based identity authentication solutions, and MorphoTrust USA ... solutions and services, today announced a strategic partnership ... across enterprise, motor vehicle administration (MVA), airport screening ... leader in identity-related solutions, MorphoTrust serves consumers through ...
(Date:11/11/2014)... Nov. 11, 2014  Forensicon, Inc., a ... pleased to announce the promotion of Yaniv Schiff ... Digital Forensics. In Schiff,s new role as Director, he ... of digital forensics examiners and provide leadership within the ... - http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined ...
(Date:11/7/2014)... , Nov. 7, 2014  In conjunction with the ... Police Departments, The Community Foundation of the Verdugos has ... DNA JUSTICE PROJECT," a $250,000 initiative to keep the ... phase. In its first six months of existence, the Lab ... evidence support for local law enforcement. "Because our ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... in spring they will most likely buy flowering ornamental ... have shown that consumers favor plants that are already ... that can present multiple challenges for commercial growers. ... like bedding plants and perennials start growing crops far ...
... They challenge the mountain ranges of the Alps, the ... known about seamounts, the vast mountains hidden under the world,s ... scientists uncover the mystery of life on these submerged ... under threat. The bathymetry of our oceans ...
... decades scientists believed Neanderthals developed `modern, tools and ... , but new research from the University of ... adapt, innovate and evolve technology on their own. ... a half-century of conventional wisdom maintaining that Neanderthals ...
Cached Biology News:Rotating high-pressure sodium lamps provide flowering plants for spring markets 2Marine scientists unveil the mystery of life on undersea mountains 2Neanderthals more advanced than previously thought 2
(Date:11/18/2014)... Sarasota, FL (PRWEB) November 17, 2014 ... novel point-of-care diagnostic tests – today announces its ... Control and Prevention’s (CDC) Get Smart About Antibiotics ... Antibiotics Week is a national campaign designed to ... local health departments, and non-profit and for-profit partners ...
(Date:11/18/2014)... November 17, 2014 Athena Signature Series: Turning ... Dr. Beverly Emerson, a professor in the Regulatory Biology Laboratory ... most recent discovery points to an “off switch” for drug ... and how her local research is making a global impact ... findings and then join host Cheryl K. Goodman, CEO of ...
(Date:11/18/2014)... 18, 2014 Brothers Josh and Bryce ... of PAWSitively Curing Cancer, Inc . in recognition ... (3) non-profit organization is dedicated to raising funds for ... to the University of Florida College of Veterinary ... Curing Cancer as the recipient of this vital funding. ...
(Date:11/18/2014)... Nov. 18, 2014 PDL BioPharma, Inc. (PDL) ... connection with the acquisition of Durata Therapeutics, Inc. by ... with the termination of PDL,s credit agreement with Durata, ... of $40 million, accrued interest, and prepayment and change ... a structured financing transaction with Durata in which PDL ...
Breaking Biology Technology:RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3PDL BioPharma Announces Successful Conclusion of Debt Financing Agreement with Durata Therapeutics 2
... ,, REYKJAVIK, Iceland , and SALT LAKE CITY, Utah , ... - U.S. Laboratories and Physicians ... , , , ... ARUP will offer deCODE,s DNA-based prostate cancer risk,assessment test to its clients nationwide. , ...
... television and computer screens could be brighter, clearer and ... by a team of researchers from Canada and the ... synthesis of a conjugated organic polymer--widely used as a ... solar cells--could mean more efficient, cheaper electronics. ...
... "Amira Pharmaceuticals, Inc. announced today that its FLAP (5-lipoxygenase-activating protein) program, which ... , , ... the program to Phase 2 studies, which explore the use of the Amira ... , , ...
Cached Biology Technology:ARUP Laboratories Ink Partnership to Offer deCODE ProstateCancer(TM) Test 2ARUP Laboratories Ink Partnership to Offer deCODE ProstateCancer(TM) Test 3ARUP Laboratories Ink Partnership to Offer deCODE ProstateCancer(TM) Test 4ARUP Laboratories Ink Partnership to Offer deCODE ProstateCancer(TM) Test 5Polymer synthesis could aid future electronics 2Amira Pharmaceuticals Hits Two Development Milestones Related to FLAP Inhibitor Program 2
8 different frozen tissues are mounted on positively charged glass slides...
Donor feline serum and plasma...
... These versatile vacuum cups provide flexible ... curved, or irregular surfaces. ,PFG: Flat ... Bellows cup ,PCG: Multiple Bellows cup ... from 25 to 200 mm , ...
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
Biology Products: