Navigation Links
New medications show promise in treating drug-resistant prostate cancer
Date:4/7/2009

ress the growth of cancer cells temporarily, but in most patients the cancer ultimately develops resistance to drugs. About 29,000 men in the United States die each year from the disease.

Prostate cancer becomes resistant to antiandrogen drugs when cancer cells begin to increase production of the androgen receptor, said Sawyers. When the level of androgen receptors on the cells' surface reaches a certain level, the drugs that originally suppressed the cancer actually begin to stimulate cancer growth.

Because of this backlash effect, many scientists have questioned whether blocking the androgen receptor is a wise course of action. But Sawyers and his colleagues believe that blocking the receptor is critical to successful treatment. So they set out to design a new generation of drugs that can block the androgen receptor without unwanted side effects, even when levels of the receptor are high.

Researchers in Sawyers' lab based their designs on a drug that tightly attaches to the site on the androgen receptor that binds testosterone. If that site is blocked, the hormone cannot bind to prostate cells and tell the receptor to stimulate growth. Using this molecule as a chemical scaffold, the researchers synthesized nearly 200 slightly different versions of the drug. They tested each one in the lab on prostate cancer cells that had been engineered to produce high levels of androgen receptor.

This screening yielded two molecules, RD162 and MDV3100, which tightly bind to the androgen receptor and did not show the cancer-stimulating effect of bicalutamide and other current antiandrogen drugs. The molecules were good candidates for drugs, because they are readily absorbed into the blood when taken orally and they persist in the bloodstream.

The researchers tested the new drugs' effectiveness in mice with tumors derived from drug-resistant prostate cancer cells. "To our delight, we found that these compounds caused very dramatic shrinkage of tumors in th
'/>"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Device prevents potential errors in childrens medications
2. Study of successful drug targets could hasten development of new medications
3. Genetic variant mimics effect of heart failure medications
4. Hypertension and cholesterol medications present in water released into the St. Lawrence River
5. Innovative civil engineering application promises cleaner waters
6. New CPR promises better results by compressing abdomen, not Chest
7. Tiny tubes and rods show promise as catalysts, sunscreen
8. New genetic research into nicotine addiction shows promise for personalized treatment
9. Genetic ancestral testing cannot deliver on its promise, study warns
10. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
11. Summer-dormant tall fescue grass shows promise for pasture improvements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Researchers in France have hit on a novel ... receive the correct and most effective treatment possible., ... the western and developing world. If left untreated, ... to renal failure and other complications. In many ... problem. Clearly a more effective pathological approach to ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
(Date:4/17/2014)... have uncovered a new way the immune system may ... efforts to use immune cells to treat illness. , ... the immunological equivalent of "neighborhood police" specialized squads ... organ, instead of an entire city, the body. , ... Louis have shown that the liver, skin and uterus ...
Breaking Biology News(10 mins):New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Some immune cells defend only 1 organ 2
... Barbara, CA The Bren School-based authors of a study ... have observed toxicity to marine organisms resulting from exposure to ... toxic under similar conditions. Lead author and assistant research ... both Bren School professors and lead scientists at the ...
... at the University of California, Riverside discovered a tiny fairyfly wasp ... United States until then. Nearly exactly a year later, he ... is well established in the country. Called Gonatocerus ater ... North America from Europe. It lays its eggs inside the ...
... New Rochelle, NY, January 24, 2012The time for commercial development ... and curable with gene therapy deserve access to the technology, ... Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy ... . Human Gene Therapy and Human Gene ...
Cached Biology News:Nano form of titanium dioxide can be toxic to marine organisms 2Wasp found in upstate New York shows up in Southern California 2Gene therapy is a 'disruptive science' ready for commercial development 2
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... BURLINGAME, Calif. , Jan. 14, 2014 As pet owners ... no doubt many of them wrote: "Take better care of my ... and even designer clothes and top-brand carrying cases to take the ... Pet parents might also feel compelled to buy some pricey toys ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. 14, ... with two institutes from the National Institutes of Health ... bringing safer, more effective treatments to patients on a ... for Advancing Translational Sciences (NCATS) and the National Eye ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... Germany will present itself as one of the,world,s ... BIO,International Convention. Under the "Breakthroughs in Regenerative Medicines,in ... into the,latest research results in the area of ... the regulatory framework conditions will be,introduced in a ...
... Corporation (Nasdaq: MATK ) announced that it intends ... 2009 on June 3, 2009, at approximately 4:00 p.m. Eastern ... Martek will conduct a conference call to discuss these results ... call live via webcast by visiting Martek,s web site at ...
... North Carolina And ChinaRESEARCH TRIANGLE PARK, N.C., May ... Health Sciences has signed an agreement with China ... Institute for International Drug Development. Building on strengths ... development, and education, the Institute will help to ...
Cached Biology Technology:BIO International Convention 2009: Research Location Germany Presents Potential in Regenerative Medicine 2The Hamner Institutes Announce Partnership With China Medical City 2The Hamner Institutes Announce Partnership With China Medical City 3