Navigation Links
New mediator of smoking recruits
Date:4/23/2009

Freiburg, Germany Current research suggests that smoking increases the production of osteopontin in the lungs, which contributes to the development of smoking-related lung disease. The related report by Prasse et al, "Essential role of osteopontin in smoking-related interstitial lung diseases," appears in the May 2009 issue of The American Journal of Pathology.

Nearly one billion people worldwide smoke tobacco products. Long-term exposure to compounds found in smoke can lead to both cardiovascular and lung disease. Although lung exposure to cigarette smoke leads to immune cell recruitment and tissue fibrosis, how cigarette smoke causes these changes is largely unknown.

To determine if osteopontin, a molecule that attracts immune cells, mediates cell recruitment in smokers, Prasse et al compared osteopontin levels from smokers with different types of lung diseases, healthy smokers, and healthy non-smokers. They found high levels of osteopontin expression in patients with interstitial lung disease, whereas healthy smokers had lower levels, and healthy non-smokers produced no osteopontin. Osteopontin expression could be stimulated directly by nicotine treatment. In addition, expressing osteopontin in rat lung resulted in recruitment of immune cells, resulting in symptoms similar to smoking-related interstitial lung diseases. These results indicate that osteopontin may be pathogenic in smoking-initiated lung disease.

The article from Prasse et al "suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]." Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Mediator in communication between neurons and muscle cells found
2. Smoking during pregnancy may impair thyroid function of mom and fetus
3. First trimester smoking linked to oral clefts
4. New research explains link between smoking and SIDS
5. Cigarette smoking may accelerate disability in those with MS
6. Climate -- no smoking gun for Neanderthals
7. Girls who begin dieting twice as likely to start smoking
8. Smoking turns on genes -- permanently
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela ... The Chancellor came to the DERMALOG stand together with the Japanese Prime ... partner country. At the largest German biometrics company the two government leaders ... iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, ... Simple," and 23andMe , the leading personal genetics ... choices.  Zipongo can now provide customers with personalized nutrition ... goals and biometrics, but also genetic markers impacting how ... Zipongo,s personalized food decision support platform uses biometrics ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... , March 29, 2017  Applied ... applying mechanistic modeling to drug research and ... collaboration with Zymeworks Inc. for quantitative systems ... therapeutics intended for the treatment of cancer. ... Zymeworks previously for GLP toxicology studies and ...
(Date:3/29/2017)... ... 29, 2017 , ... Bactana Animal Health, a company developing natural products aimed ... enhancement of the gut microbiota, today announced the closing of its first round of ... Sustainable Income Capital Management, LLC and a number of private investors. The company will ...
(Date:3/29/2017)... Research and Markets has announced the ... Markets" report to their offering. ... The study scope includes ... RNA interference, synthetic biology tools and genome editing tools); synthetic ... These technologies and products are analyzed to determine present and ...
(Date:3/28/2017)... ... March 28, 2017 , ... Franz Inc ., the leading ... , has been named a ‘Champion’ by Bloor Research in its recent Graph ... in its class, and, thanks to Gruff, it was rated as the easiest product ...
Breaking Biology Technology: