Navigation Links
New mediator of smoking recruits
Date:4/23/2009

Freiburg, Germany Current research suggests that smoking increases the production of osteopontin in the lungs, which contributes to the development of smoking-related lung disease. The related report by Prasse et al, "Essential role of osteopontin in smoking-related interstitial lung diseases," appears in the May 2009 issue of The American Journal of Pathology.

Nearly one billion people worldwide smoke tobacco products. Long-term exposure to compounds found in smoke can lead to both cardiovascular and lung disease. Although lung exposure to cigarette smoke leads to immune cell recruitment and tissue fibrosis, how cigarette smoke causes these changes is largely unknown.

To determine if osteopontin, a molecule that attracts immune cells, mediates cell recruitment in smokers, Prasse et al compared osteopontin levels from smokers with different types of lung diseases, healthy smokers, and healthy non-smokers. They found high levels of osteopontin expression in patients with interstitial lung disease, whereas healthy smokers had lower levels, and healthy non-smokers produced no osteopontin. Osteopontin expression could be stimulated directly by nicotine treatment. In addition, expressing osteopontin in rat lung resulted in recruitment of immune cells, resulting in symptoms similar to smoking-related interstitial lung diseases. These results indicate that osteopontin may be pathogenic in smoking-initiated lung disease.

The article from Prasse et al "suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]." Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Mediator in communication between neurons and muscle cells found
2. Smoking during pregnancy may impair thyroid function of mom and fetus
3. First trimester smoking linked to oral clefts
4. New research explains link between smoking and SIDS
5. Cigarette smoking may accelerate disability in those with MS
6. Climate -- no smoking gun for Neanderthals
7. Girls who begin dieting twice as likely to start smoking
8. Smoking turns on genes -- permanently
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/17/2016)... 17, 2016 Global Market Watch: Primarily ... Banks, Population-Based Banks and Academics) market is to witness a ... Biobanks shows the highest Compounded Annual Growth Rate (CAGR) of ... during the analysis period 2014-2020. North America ... followed by Europe at 9.56% respectively. ...
(Date:11/14/2016)... Nov. 14, 2016  xG Technology, Inc. ("xG" or ... critical wireless communications for use in challenging operating environments, ... 30, 2016. Management will hold a conference call to ... p.m. Eastern Time (details below). Key Recent ... $16 million binding agreement to acquire Vislink Communication Systems. ...
(Date:6/22/2016)... -- On Monday, the Department of Homeland Security (DHS) ... for the Biometric Exit Program. The Request for Information ... explains that CBP intends to add biometrics to confirm ... States , in order to deter visa overstays, ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... PHILADELPHIA , Dec. 8, 2016  Partnering to ... ecosystem, Ben Franklin Technology Partners of Southeastern ... Group ("IHG"), the parent company of Independence Blue Cross; ... today announced their intentions for a $6 million funding ... early-stage healthcare startups. Responding to a burgeoning ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... it has become a Wonderware Certified System Integrator Partner. Huffman Engineering is ... Electric Software. , “The System Integrator Partner certification gives customers confidence that our ...
(Date:12/7/2016)... , Dec. 7, 2016  Nordion, a standalone ... Atomics (GA), welcome today,s award by the United ... Administration (NNSA) of the Phase II cooperative agreement ... Nordion and the University of Missouri Research Reactor ... will support the establishment of a new, reliable ...
(Date:12/7/2016)... Texas , Dec. 7, 2016  Genprex, ... of revolutionary immunogene therapy treatments, today announced that ... practice within a leading strategic communications and advisory ... communications program. The program will combine investor relations, ... objective of raising the profile of Genprex and ...
Breaking Biology Technology: