Navigation Links
New mechanism for cardiac arrhythmia discovered
Date:9/18/2008

It has long been thought that virus infections can cause cardiac arrhythmia. But why has not been understood. Ulrike Lisewski, Dr. Yu Shi, Michael Radke and Professor Michael Gotthardt of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered the molecular mechanism. The researchers demonstrated that the receptor which the virus uses to infect heart cells is normally necessary for regular heart beat in mice. Likewise, when the receptor is absent or non-functioning, arrhythmia occurs. They assume that both the virus infection and the autoimmune disease can block the receptor which, in turn, disrupts the heart's normal rhythm. The study has now been published online in the Journal of Experimental Medicine (10.1084/jem.20510iti3).

The heart consists of two ventricles and two atria. In order to beat correctly and to pump blood through the body, specialized heart fibres generate electric signals that control the heart beat. Cardiac arrhythmia occurs when these signals are not correctly generated or forwarded. There, a receptor, which scientists call CAR, plays an important role.

CAR stands for Coxsackievirus-Adenovirus-Receptor. It is embedded in specific cell-cell-contacts (tight junctions) of the specialized heart fibres. CAR was discovered as the critical protein responsible for virus entry during infection with Coxsackie and Adenoviruses. Its role in the adult heart was previously unknown.

To investigate CAR's task in a healthy organism, the MDC-scientists switched off the CAR-gene in adult mice. As a result, the rodents could no longer produce the receptors and developed cardiac arrhythmia. "That is an interesting observation because these special cell-cell-contacts, the tight junctions, have not been connected to arrhythmia so far", Professor Gotthardt says.

A detailed analysis of the animals showed that the transfer of electric signals from the atria to the ventricles does not work properly. "When CAR is missing, the signal can not be passed on and the heart does not beat properly," Dr. Shi says.

Professor Gotthardt now wants to investigate whether CAR is blocked in patients with arrhythmia. "However, it does not always have to be connected to a virus infection," he says. "The body's own antibodies directed against CAR could cause the disease as well."


'/>"/>

Contact: Barbara Bachtler
presse@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Novel anti-cancer mechanism found in long-lived rodents
2. Oxidative stress: Mechanism of cell death clarified
3. Researchers discover cells quality control mechanism
4. Discovery of a mechanism that regulates cell movement
5. UCLA study identifies mechanism behind mind-body connection
6. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
7. Scientists reveal the key mechanisms for affinity between transient binding proteins
8. A single mechanism for hypertension, insulin resistance and immune suppression
9. Mechanism and function of humor identified by new evolutionary theory
10. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
11. Mechanism explains link between apolipoprotein E and Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/23/2017)... 23, 2017 The report "Gesture Recognition and Touchless Sensing ... Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is expected ... 29.63% between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 , ... ... into a different cell type. Many treatments for specific cancers, such as breast, ... of targeted treatment is androgen deprivation therapy for advanced prostate cancer. , ...
(Date:8/16/2017)... year,s edition of the Inc. 5000 features a now-familiar name: BioPoint ( ... the list for the third year in a row. Now in its ... on a set of quantitative metrics. In addition, BioPoint was also named ... Bay State . ... 5000 ...
(Date:8/15/2017)... San Diego, CA (PRWEB) , ... August 15, ... ... science company pioneering graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces the ... reduces the number of steps needed to gain kinetic binding data for a ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... The ... time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming panels and events. ... February 7-9, 2018, at The Roosevelt Hotel in New York City. , “With our ...
Breaking Biology Technology: