Navigation Links
New mechanism for cardiac arrhythmia discovered
Date:9/18/2008

It has long been thought that virus infections can cause cardiac arrhythmia. But why has not been understood. Ulrike Lisewski, Dr. Yu Shi, Michael Radke and Professor Michael Gotthardt of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered the molecular mechanism. The researchers demonstrated that the receptor which the virus uses to infect heart cells is normally necessary for regular heart beat in mice. Likewise, when the receptor is absent or non-functioning, arrhythmia occurs. They assume that both the virus infection and the autoimmune disease can block the receptor which, in turn, disrupts the heart's normal rhythm. The study has now been published online in the Journal of Experimental Medicine (10.1084/jem.20510iti3).

The heart consists of two ventricles and two atria. In order to beat correctly and to pump blood through the body, specialized heart fibres generate electric signals that control the heart beat. Cardiac arrhythmia occurs when these signals are not correctly generated or forwarded. There, a receptor, which scientists call CAR, plays an important role.

CAR stands for Coxsackievirus-Adenovirus-Receptor. It is embedded in specific cell-cell-contacts (tight junctions) of the specialized heart fibres. CAR was discovered as the critical protein responsible for virus entry during infection with Coxsackie and Adenoviruses. Its role in the adult heart was previously unknown.

To investigate CAR's task in a healthy organism, the MDC-scientists switched off the CAR-gene in adult mice. As a result, the rodents could no longer produce the receptors and developed cardiac arrhythmia. "That is an interesting observation because these special cell-cell-contacts, the tight junctions, have not been connected to arrhythmia so far", Professor Gotthardt says.

A detailed analysis of the animals showed that the transfer of electric signals from the atria to the ventricles does not
'/>"/>

Contact: Barbara Bachtler
presse@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel anti-cancer mechanism found in long-lived rodents
2. Oxidative stress: Mechanism of cell death clarified
3. Researchers discover cells quality control mechanism
4. Discovery of a mechanism that regulates cell movement
5. UCLA study identifies mechanism behind mind-body connection
6. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
7. Scientists reveal the key mechanisms for affinity between transient binding proteins
8. A single mechanism for hypertension, insulin resistance and immune suppression
9. Mechanism and function of humor identified by new evolutionary theory
10. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
11. Mechanism explains link between apolipoprotein E and Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... starfish, and corals have in common? Aside from ... that use calcium from their environment to create ... protection. , The July issue of The ... Laboratory, addresses the challenges faced by these species ... carbon dioxide rises, the world,s oceans are becoming ...
(Date:7/23/2014)... July 23, 2014   MedNet Solutions , ... clinical study management systems, is pleased to announce ... life sciences industry executive with over 25 years ... (COO).  Clareece will be responsible for MedNet,s day-to-day ... efficiency and quality product/service delivery.  ...
(Date:7/23/2014)... news release is available in German . ... varying sensory modalities for orientation, some of which might ... example take the polarization pattern produced by sunlight in ... from the Max Planck Institute for Ornithology in Seewiesen, ... from Israel that a night active mammal, the greater ...
Breaking Biology News(10 mins):Calcification in changing oceans explored in special issue of The Biological Bulletin 2MedNet Appoints Clareece West As Chief Operating Officer 2Bats use the evening sky's polarization pattern for orientation 2
... help to raise the offspring of other group members are ... for more distant kin, a new study has found., The ... Australia, the chestnut-crowned babbler, also found that these birds work ... the young of less-related group members., The findings, published in ...
... Elser today received the G. Evelyn Hutchinson Award, the ... the July 2012 Association for the Sciences of Limnology ... Lake Biwa, Otsu, Shiga, Japan. The Hutchinson Award is ... 10 years of excellence in limnology (the study of ...
... CORVALLIS, Ore. Scientists have discovered two viruses that appear ... are important for coral growth and health, and they say ... of coral ecosystems around the world. These viruses, ... have been shown for the first time to clearly be ...
Cached Biology News:Helping family is key for social birds 2ASU ecologist receives prestigious global award for water research 2ASU ecologist receives prestigious global award for water research 3Viruses linked to algae that control coral health 2
(Date:7/23/2014)... VEGAS , July 23, 2014  GrowBLOX Sciences, Inc. ... today that it is filing for two medical marijuana dispensary ... locations are in addition to the Clark County, ... a special use permit, as previously announced.  GrowBLOX ... to be submitting two new applications for dispensaries in the ...
(Date:7/23/2014)... 23, 2014 a2z Inc. announces that ... App, AACC Pathfinder, in its 2014 Annual Meeting ... meeting is planned for July 29-31, 2014 in Chicago, ... be to connect with global leaders in clinical chemistry, ... other areas of breaking science in laboratory medicine. , ...
(Date:7/22/2014)... D.C., June 22, 2014 Even within a phylum so ... is distinguished among other arthropods for its cruelty -- at ... Central America, the fly is a most predatory sort of ... cricket, deposits a smear of larvae, and leaves its wicked ... out. , None of this would be possible without ...
(Date:7/22/2014)... July 22, 2014 Nuclear reactors are ... produced by controlled fission chain reaction in nuclear reactors ... is used to drive a power- generating turbine. Currently ... the world’s total electricity production. Nuclear reactor market is ... construction, planned and proposed nuclear reactor projects. , Early ...
Breaking Biology Technology:GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 3Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 2Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 3
... , , , ... VOLC ), a leader in the development, manufacturing and sales of ... disease, announced today its participation in the 2009 Transcatheter Cardiovascular Therapeutics ... for TCT includes a first look at new study data, live ...
... ROCKVILLE, Md., Sept. 21 Neuralstem, Inc. (NYSE Amex: ... (FDA) has approved its Investigational New Drug (IND) application to commence a ... disease) with its spinal cord stem cells. , , ... Neuralstem is the first company to commence a stem cell ...
... , NES-ZIONA, Israel, Sept. 21 PROLOR Biotech, ... the initiation of a Phase I clinical trial of its ... hGH-CTP is being developed to provide growth hormone ... multiple injections per week that are currently required with a ...
Cached Biology Technology:Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 2Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 3Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 4Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 5Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 6Neuralstem Receives FDA Approval to Commence First ALS Stem Cell Trial 2Neuralstem Receives FDA Approval to Commence First ALS Stem Cell Trial 3Neuralstem Receives FDA Approval to Commence First ALS Stem Cell Trial 4PROLOR Biotech Announces Initiation of Phase I Clinical Trial for its Long-Acting Growth Hormone 2PROLOR Biotech Announces Initiation of Phase I Clinical Trial for its Long-Acting Growth Hormone 3PROLOR Biotech Announces Initiation of Phase I Clinical Trial for its Long-Acting Growth Hormone 4