Navigation Links
New mechanical insights into wound healing and scar tissue formation
Date:12/17/2007

New research published today in the Journal of Cell Biology illuminates the mechanical factors that play a critical role in the differentiation and function of fibroblasts, connective tissue cells that play a role in wound healing and scar tissue formation.

When we are injured, the body launches a complex rescue operation. Specialized cells called fibroblasts lurking just beneath the surface of the skin jump into action, enter the provisional wound matrix (the clot) and start secreting collagen to close the wound as fast as possible. This matrix is initially soft and loaded with growth factors. The fibroblasts "crawl" around the matrix, pulling and reorganizing the fibers. The matrix grows stiffer, and at a certain point, the fibroblasts stop migrating and, like Popeye, change into powerful contractile cells, anchoring themselves to the matrix and pulling the edges of the wound together.

The research reported today reveals for the first time that a mechanical mechanism is crucial for this switch from migrating to contractile cells. To make this change, the fibroblasts need to get at their "spinach" -- the growth factor sitting in the matrix which, once liberated, stimulates the production of smooth-muscle proteins. Previously, researchers postulated that the fibroblasts did this by digesting the matrix. But EPFL scientist Boris Hinz, doctoral student Pierre-Jean Wipff and their colleagues have discovered that the cells unlock the growth factor via a purely mechanical process. With experiments using novel cell culture substrates of varying rigidity, they found that at a certain point, the matrix is sufficiently rigid that cell-exerted force allows the growth factor to pop out, like candy from a wrapper. Once the growth factor is available, the fibroblast expresses the contractile proteins, sticks more firmly to the matrix and starts to contract, pulling the matrix tightly together. In the process it liberates yet more growth factor that i
'/>"/>

Contact: Mary Parlange
mary.parlange@epfl.ch
41-216-937-022
Ecole Polytechnique Fdrale de Lausanne  
Source:Eurekalert

Page: 1 2

Related biology news :

1. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
2. Stomach stem cell discovery could bring cancer insights
3. KGI professor contributes new insights on jumping genes
4. Study involving more than 100 scientists provides new insights on green algae
5. New insights into how lasers cut flesh
6. Tumor genome analysis unveils new insights into lung cancer
7. New insights into the fate of antiparasitics in manure and manured soils
8. Hinode: new insights on the origin of solar wind
9. Sea cucumbers fast track organ regrowth by healing their wounds
10. A step toward tissue-engineered heart structures for children
11. Researchers create system to build transplant tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New mechanical insights into wound healing and scar tissue formation
(Date:9/2/2014)... The Field Museum will present the prestigious Parker/Gentry Award ... commitment to biodiversity conservation awareness. The Parker/Gentry Award is ... individual, team or organization whose efforts have had a ... and whose actions can serve as a model to ... an environmental science and conservation news website that draws ...
(Date:9/2/2014)... a history of scientific research on mountain ecosystems, ... systems, and sets an agenda for biodiversity conservation ... "Mountain gloom and mountain glory revisited: A survey ... regions," appears online in the Journal of ... of Tufts University, Jodi A. Hilty of the ...
(Date:9/2/2014)... JUPITER, FL, September 2, 2014 In a new ... scientists from the Florida campus of The Scripps Research ... diseased cells into unique manufacturing sites for molecules that ... using a cell as a reaction vessel and a ... in a diseased cell," said TSRI Professor Matthew Disney.,"Because ...
Breaking Biology News(10 mins):An uphill climb for mountain species? 2An uphill climb for mountain species? 3Scripps Florida scientists make diseased cells synthesize their own drug 2
... turtles are too optimistic, according to Loren McClenachan ... McClenachan, Jeremy Jackson and Marah Newman agree ... helped increase green and hawksbill turtle populations that ... that dwindling turtle populations on many historically important ...
... population in New Hampshire's Great Bay estuary has plummeted by ... disease MSX. The previous century saw a slower but equally ... local extinction on some reefs," says Ray Grizzle, research associate ... , Now Grizzle is working to bring oysters back ...
... a surprisingly high percentage of people with type 1 ... years or longer (The Joslin Medalists) may still have ... The findings will be presented June 12 at the ... Washington, D.C. , "It is surprising that some ...
Cached Biology News:All the eggs in one basket 2All the eggs in one basket 3UNH researcher restoring oyster reefs to Great Bay 2Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes 2Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes 3
(Date:8/31/2014)... -- Wockhardt Limited today announces a major boost to ... two of its drugs, WCK 771 and WCK 2349, ... from U.S. Food & Drug Administration (FDA).  QIDP status ... have a high degree of unmet need in their ... (a top U.S. government health and safety body).  QIDP ...
(Date:8/31/2014)... 31, 2014 2014 Market ... a professional and in-depth research report on ... Polyacrylamide information, including Polyacrylamide definition, classification, application, ... industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment ...
(Date:8/30/2014)... 31, 2014 The Global and ... and in-depth study on the current state of ... China. , The report provides a basic overview ... chain structure. Global market analysis and Chinese domestic ... history, developments, trends and competitive landscape of the ...
(Date:8/29/2014)... on electrons, but one of the most promising technologies ... based on light (photons) instead of electrons. First, it ... of single photons and control their direction. Researchers around ... achieve this control, but now scientists at the Niels ... of photons emitted one at a time and in ...
Breaking Biology Technology:U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Breakthrough in light sources for new quantum technology 2
... CARLSBAD, Calif., Dec. 14 Isis,Pharmaceuticals, Inc. (Nasdaq: ... of,Directors has promoted B. Lynne Parshall, J.D. to ... position as Chief Financial,Officer, and is a Director ... and appropriately reflects the scope,of Lynne,s responsibilities at ...
... /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS; Nasdaq: PXSL) today announced ... its asthma diagnostic tool, Aridol in Portugal., ... included in the,successful mutual recognition procedure earlier this ... "Bronchial challenge testing is a common procedure ...
... Corporation (NYSE:,FMC) and Pronova BioPharma ASA (OSE: ... a worldwide license and development agreement to ... by FMC. The,alginate-based capsule technology is expected ... Pronova BioPharma,s products and has,the potential for ...
Cached Biology Technology:Isis Announces Appointment of B. Lynne Parshall as Chief Operating Officer 2Isis Announces Appointment of B. Lynne Parshall as Chief Operating Officer 3Pharmaxis Appoints Portuguese Distributor for Aridol 2FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsule Products 2FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsule Products 3FMC Corporation and Pronova BioPharma Announce Agreement To Develop New Alginate-Based Capsule Products 4