Navigation Links
New mechanical insights into wound healing and scar tissue formation
Date:12/17/2007

New research published today in the Journal of Cell Biology illuminates the mechanical factors that play a critical role in the differentiation and function of fibroblasts, connective tissue cells that play a role in wound healing and scar tissue formation.

When we are injured, the body launches a complex rescue operation. Specialized cells called fibroblasts lurking just beneath the surface of the skin jump into action, enter the provisional wound matrix (the clot) and start secreting collagen to close the wound as fast as possible. This matrix is initially soft and loaded with growth factors. The fibroblasts "crawl" around the matrix, pulling and reorganizing the fibers. The matrix grows stiffer, and at a certain point, the fibroblasts stop migrating and, like Popeye, change into powerful contractile cells, anchoring themselves to the matrix and pulling the edges of the wound together.

The research reported today reveals for the first time that a mechanical mechanism is crucial for this switch from migrating to contractile cells. To make this change, the fibroblasts need to get at their "spinach" -- the growth factor sitting in the matrix which, once liberated, stimulates the production of smooth-muscle proteins. Previously, researchers postulated that the fibroblasts did this by digesting the matrix. But EPFL scientist Boris Hinz, doctoral student Pierre-Jean Wipff and their colleagues have discovered that the cells unlock the growth factor via a purely mechanical process. With experiments using novel cell culture substrates of varying rigidity, they found that at a certain point, the matrix is sufficiently rigid that cell-exerted force allows the growth factor to pop out, like candy from a wrapper. Once the growth factor is available, the fibroblast expresses the contractile proteins, sticks more firmly to the matrix and starts to contract, pulling the matrix tightly together. In the process it liberates yet more growth factor that i
'/>"/>

Contact: Mary Parlange
mary.parlange@epfl.ch
41-216-937-022
Ecole Polytechnique Fdrale de Lausanne  
Source:Eurekalert

Page: 1 2

Related biology news :

1. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
2. Stomach stem cell discovery could bring cancer insights
3. KGI professor contributes new insights on jumping genes
4. Study involving more than 100 scientists provides new insights on green algae
5. New insights into how lasers cut flesh
6. Tumor genome analysis unveils new insights into lung cancer
7. New insights into the fate of antiparasitics in manure and manured soils
8. Hinode: new insights on the origin of solar wind
9. Sea cucumbers fast track organ regrowth by healing their wounds
10. A step toward tissue-engineered heart structures for children
11. Researchers create system to build transplant tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New mechanical insights into wound healing and scar tissue formation
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
(Date:11/18/2014)...   News Highlights: ... The Partners Data Lake, an agile data and ... will allow researcher and clinicians to explore and ... lives of patients , The Partners Data ... the Partners system, breaking down physical barriers for ...
(Date:11/15/2014)... YORK , Nov. 13, 2014  While we may ... technology Doctor McCoy used in "Star Trek" to gain instant ... tools designed to work with smartphones and tablets for monitoring ... of the healthcare world. This may seem a tad Orwellian ... ready to adopt some of these technological opportunities into their ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... Registration is now open for Disease Models & ... Mechanisms. This one-day Symposium will ... and disease processes at the cellular and whole-organism ... be used to address this issue. It is ...
... flower, created by the union of two foreign plant species, ... Genetic changes in this attractive yellow-flowered hybrid have allowed it to ... new species that has originated in the wild in the last ... to have originated in this way, yet only a handful of ...
... A San Francisco State University biologist has released the ... bee populations and has found low numbers of bees in ... habitat loss is one of the primary reasons for sharp ... Now the researcher plans to add to her data ...
Cached Biology News:Rare glimpse into the origin of species 2SF State researcher releases first results from nationwide bee count 2SF State researcher releases first results from nationwide bee count 3
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Achim Noack ... administration for Stoller Group. In this position, Noack will ... on administrative matters, develop marketing strategy and supervise global ... , “Achim has tremendous knowledge and experience in ... Stoller Group. “His experience and innovative thinking will be ...
(Date:12/17/2014)... Beach, CA (PRWEB) December 17, 2014 ... Inc. to provide a larger packaged waste water treatment ... in King Abdullah Economic City (KAEC). Two years ago ... EMAAR’s Jeddah Gate Development, serving two residential towers with ... capacity is over a quarter million gallons per day ...
(Date:12/17/2014)... 2014 Xeno Diagnostics has again ... most recent COLA inspection. Xeno has met all ... healthcare accreditation organization. Accreditation is earned only by ... day-to-day operations, demonstrate continued accuracy in the performance ... laboratory survey. , While the Laboratory ...
Breaking Biology Technology:Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... NESS ZIONA, Israel, August 24 Foamix ... gynecology, announced today,that it has been awarded US Patent ... foam compositions, suitable for the,treatment of heat and chemical ... Dr. Dov Tamarkin, the Company,s CEO stated, ...
... This ... about how -- or even whether -- invasive saltcedar should be controlled. The Society ... natural ecosystems and carefully weigh the impact of our decisions. , ... Lawrence, KS (PRWEB) August 24, 2009 -- Saltcedar (Tamarix ...
... TONBRIDGE, England, Aug. 21 Pharmacists have branded government ... after the profession was excluded from the first wave of healthcare ... week health secretary Andy Burnham announced the list of priority patient ... However, the Department of Health [DH] list of "frontline health ...
Cached Biology Technology:Foamix Receives US Patent on Novel Foam Technology 2Invasive Saltcedar Triggers Lively Debate among Weed Scientists and Land Managers 2Invasive Saltcedar Triggers Lively Debate among Weed Scientists and Land Managers 3Chemist+Druggist Reveals Frontline NHS Staff Won't Get Swine Flu Vaccine 2
...
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
...
... area that will help protect your PCR ... the work area prior to use, reducing ... amplified. Containment features reduce the chance of ... windows for a clear view, an acid-resistant ...
Biology Products: