Navigation Links
New measurement of telomeres; DNA could help identify most viable embryos for IVF
Date:6/28/2010

Scientists from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust, are the first to directly measure a specific region of DNA in human embryos. The length of this region could be a quality marker for embryonic development.

Researchers at the University of Warwick's Warwick Medical School and University Hospital, Coventry, have measured telomeres, regions of repetitive DNA at the ends of a chromosome which protect it from deterioration. Telomeres shorten each time a cell divides and when telomere length becomes critically short, the cells die.

The research, published in Molecular Human Reproduction Journal, suggests that telomere length is shortest in the early stages of an embryo's development, at around two days, and then lengthens just before implantation in the womb at five days. This lengthening may be essential for normal development, because short telomeres may not be enough to survive the many rounds of cell division that take place as embryos grow.

Lead authors Professor Geraldine Hartshorne, from the University of Warwick's Warwick Medical School, and Sarah Turner, from University Hospital , Coventry, said this discovery could have implications for IVF treatment.

Professor Hartshorne said: "It has already been shown that artificially shortened telomeres cause problems in animal embryos. Human embryos are highly variable, and many of them cannot develop normally. We think that telomere length might one day be used to help diagnose which are the most viable embryos. We also know that telomeres shorten with oxidative stress, so telomere length might also provide a measure of the stressfulness of the culture systems that we use in IVF and their impact on embryos."

The research project used oocytes and embryos donated by patients undergoing IVF treatment. Only material that could not be used for the patients' own treatment was accessed for research.

Sarah Turner said: These results have given us plenty of new questions as well as answers. We now need to find out why telomere length is relatively short in early development. Our next steps are looking at single sperm and eggs to work out where the telomere length in early embryos is coming from. "


'/>"/>

Contact: Peter Dunn
p.j.dunn@warwick.ac.uk
44-247-652-4668
University of Warwick
Source:Eurekalert

Related biology news :

1. Unprecedented global measurement network achieves full coverage of oceans
2. Measurement Specialties, Inc. Announces Impact of German Business Tax Reform 2008 Resulting in Lower Combined German Tax Rate - Impacts 2Q08 Reported Financial Results
3. Worldwide atmospheric measurements will determine the role of atmospheric fine particles
4. LDL particle measurement by NMR recognized by ADA, ACC
5. Scientists demonstrate the sharpest measurement of ice crystals in clouds
6. Successful series of measurements in Arctic sea ice
7. UI researchers help to improve carbon measurements in global climate studies
8. Carbon accounting from atmospheric measurements -- the aircraft perspective
9. Innerscope Research Adds to Its Advisory Board Two Pioneers in the Measurement and Application of Emotional Engagement
10. NIST issues human milk and blood serum SRMs for contaminant measurements
11. Innerscope Research Adds to Its Advisory Board Two Pioneers in the Measurement and Application of Emotional Engagement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:8/18/2017)... ... August 18, 2017 , ... ... will feature Federal Hybrids, Inc. in an upcoming episode, scheduled to broadcast fourth ... Farmer will explore Federal Hybrids, the independent, family-owned seed company. Educating audiences about ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... Tunnell ... part in sessions at the ISPE Annual Meeting and Expo , to be ... Diego Marina. The event’s theme is “Driving innovation to advance patient therapies.” , The ...
(Date:8/16/2017)... Columbus, OH (PRWEB) , ... August 16, 2017 ... ... of a beneficial microbe delivery system, announced it has secured $2M in funding ... Funds, Queen City Angels, Carmen Innovations, and SVG Thrive Fund. With this investment, ...
(Date:8/15/2017)... , Aug. 15, 2017 After spending the past ... support with crowdsourced data collection, GeneFo now offers this platform to ... aligning and amplifying support, adherence, and data collection vis a vis ... foundations mark the successful launch of this offer. ... GeneFo ...
Breaking Biology Technology: