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New materials, progress toward an HIV vaccine, and more at meeting of crystallographers
Date:7/1/2013

"Our goal is to improve both patient tolerance and overall drug efficacy by using structural and chemical biology to potently target an intestinal microbial enzyme."

Abstract 13.01.3: http://www.amercrystalassn.org/app/session/100131

Facebook for Minerals

"CEO Mark Zuckerberg, in Jan 2013 announced to employ graph-search where the entire Facebook is expressed as a graph of infinitely extensible collection of documents.... We have been developing rule-based approaches to create such indexes for a warehouse of chemical structures and biomedical data."

Abstract 03.01.11: http://www.amercrystalassn.org/app/session/100111?page=1

Photosynthetic Proteins Caught in Action

"We believe that we have visualized the protein-quake that occurs as a large amount of energy is absorbed by a light-driven protein and this energy is rapidly dissipated into the surrounding solvent before the protein unfolds."

Abstract 11.03.10: http://www.amercrystalassn.org/app/session/100127

Anti-Plague Drugs

"Yersinia pestis, the causative agent of bubonic plague and a potential bioweapons agent, requires a highly active protein tyrosine phosphatase, YopH, for pathogenicity. We have identified a potent and non-promiscuous inhibitor with good selectivity against a panel of phosphatases that exhibits significant inhibition of intracellular Y. pestis replication."

Abstract 12.02.13: http://www.amercrystalassn.org/app/session/100130

New Ways to Fight Superbugs

"Gram negative bacteria (GNB) are becoming increasingly resistant to our current arsenal of antibiotics with new
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Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

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