Navigation Links
New markers for allergic disorders thanks to analysis of medical databases
Date:1/11/2011

Researchers at the University of Gothenburg, Sweden, have developed new methods for analysing medical databases that can be used to identify diagnostic markers more quickly and to personalise medication for allergic disorders. They could also reduce the need for animal trials in clinical studies.

Published in the journal PLoS Computational Biology, the study builds on data analyses of freely available medical databases representing studies of countless numbers of patients in the

PubMed database, and microarray data in another major database. The use of microarrays is a method that allows scientists to study all 20,000 human genes at the same time for various disorders.

Groups of researchers in Gothenburg, Oslo and Rome have developed computational methods to simulate how a change in the interaction between several different genes in the lymphocytes (a kind of white blood cell) controls the immune system. They identified the genes by reviewing abstracts of all 18 million articles included in PubMed, and then constructed a network model of how these genes interact.

"The model can be compared to a printed circuit card in the lymphocyte which the cell uses to make decisions about whether to activate or suppress the immune system," says Mikael Benson, a researcher at the Sahlgrenska Academy's Unit for Clinical Systems Biology and consultant at the Queen Silvia Children's Hospital. "These decisions are made constantly as the lymphocytes are constantly exposed to different particles, just through breathing for example. Some of the particles could be dangerous and need to trigger a decision to mobilise the immune system. However, sometimes wrong decisions are made, which can lead to various disorders such as allergy or diabetes."

The researchers then carried out data simulations of how the network model reacted to repeated exposure to particles, which resulted in four reaction patterns, one of which was to suppress th
'/>"/>

Contact: Mikael Benson
mikael.benson@vgregion.se
46-031-343-5162
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomarkers for identifying infant infections
2. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
3. Eosinophils as markers for asthma
4. Tiny samples could yield big predictive markers for pancreatic cancer
5. New tumor markers determine therapy intensity
6. Researchers identify genetic markers for aggressive head and neck cancer
7. Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection
8. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
9. Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues
10. Assessing lead time of selected ovarian cancer biomarkers
11. Pacific Biometrics, Inc. Stockholders Approve Company Name Change to Pacific Biomarkers, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology ... today announced the availability of the VeriLook ... Surveillance 3.0 provides real-time biometric face identification using ... digital surveillance cameras. The new version not only ... differentiates people from objects while they are moving ...
(Date:10/14/2014)... ITHACA, N.Y. – Scientists have sequenced the house fly ... as one might expect from an insect that thrives ... research, published Oct. 14 in the journal Genome ... and biology and of how flies quickly adapt to ... , Adult house flies (Musca domestica) carry and transmit ...
(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... Tech Wake Forest University,s School of Biomedical Engineering and ... and Simulation Award for 2008. The Office of ... of the Army presented the award for research that could ... with facial injury. The center was selected from ...
... up to half of a person,s body mass consisting ... which include those found in the limbs can ... of Illinois kinesiology and community health professor Kimberly Huey, ... Vitamin E may be associated with reduced expression of ...
... as of January 2009. The official journal of the ... is respected internationally for the publication of basic and ... areas relevant to fisheries science. Published in ... includes original and review articles covering a wide array ...
Cached Biology News:New dummy design and development wins US Department of Defense award 2Vitamin E shows possible promise in easing chronic inflammation 2Vitamin E shows possible promise in easing chronic inflammation 3
(Date:10/20/2014)... GAITHERSBURG, Md. , Oct. 20, 2014  GenVec, Inc. ... Zola P. Horovitz , Ph.D., from its board of ... GenVec board in August 2003, and served as its chairman ... also served on the Nominating and Corporate Governance and Audit ... Zola for more than a decade of dedicated service to ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The ... bromine market in Asia-Pacific with analysis and forecast ... the Asia Pacific Bromine Market report, to get ... also provides a glimpse of the segmentation in ... various tables and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems report ... and forecast of revenue. The Orthopedic braces and support systems ... million by 2018, at a developing CAGR of 4.4% from ... Asian Orthopedic braces and support systems market, to get an ... glimpse of the segmentation of orthopedic braces and support systems ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... Silence Therapeutics plc (London AIM:,SLN), a leading ... reasons, Jeffery Vick has resigned as Group CEO ... has appointed Iain Ross, currently Non-Executive,Chairman, full time ... Cook, a Non-Executive Director of the Company has ...
... Ltd. (Nasdaq: XTLB ; TASE: XTL) announces ... Meeting ("EGM") scheduled,for today were adjourned and postponed ... pm Israel time, respectively., ABOUT XTL BIOPHARMACEUTICALS ... in the development of,therapeutics for the treatment of ...
... Channel Targets for ... at 10:10, CLEVELAND, July 17 ChanTest,s role ... and services for,drug-discovery and development applications will be featured ... The Cleveland-based,company will be exhibiting in booth 839 its ...
Cached Biology Technology:Organizational Changes at Silence Therapeutics 2Organizational Changes at Silence Therapeutics 3ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Drug Discovery Technology, Booth 839 2ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Drug Discovery Technology, Booth 839 3
... RNA sequences from high throughput synthesis are new ... LC Sciences. These products provide a large number ... sequences delivered in a microtube as a mixture ... verified RNA sequence. This is a custom product ...
Chicken polyclonal antibody to Glutathione-S-Transfrease (GST)...
... The gold standard for automated ... of bioanalytical applications • Based on ... • Automated accessories designed for bioresearch ... light • Versatility, reliability and ease-of-use ...
... Arrays contain 60 rabbit tissue samples arrayed on ... unstained slides and 1 hematoxylin and eosin (H&E) ... 15 different tissues from 4 rabbit organisms, for ... Each tissue sample (or core) is 1.5 mm ...
Biology Products: