Navigation Links
New markers for allergic disorders thanks to analysis of medical databases
Date:1/11/2011

Researchers at the University of Gothenburg, Sweden, have developed new methods for analysing medical databases that can be used to identify diagnostic markers more quickly and to personalise medication for allergic disorders. They could also reduce the need for animal trials in clinical studies.

Published in the journal PLoS Computational Biology, the study builds on data analyses of freely available medical databases representing studies of countless numbers of patients in the

PubMed database, and microarray data in another major database. The use of microarrays is a method that allows scientists to study all 20,000 human genes at the same time for various disorders.

Groups of researchers in Gothenburg, Oslo and Rome have developed computational methods to simulate how a change in the interaction between several different genes in the lymphocytes (a kind of white blood cell) controls the immune system. They identified the genes by reviewing abstracts of all 18 million articles included in PubMed, and then constructed a network model of how these genes interact.

"The model can be compared to a printed circuit card in the lymphocyte which the cell uses to make decisions about whether to activate or suppress the immune system," says Mikael Benson, a researcher at the Sahlgrenska Academy's Unit for Clinical Systems Biology and consultant at the Queen Silvia Children's Hospital. "These decisions are made constantly as the lymphocytes are constantly exposed to different particles, just through breathing for example. Some of the particles could be dangerous and need to trigger a decision to mobilise the immune system. However, sometimes wrong decisions are made, which can lead to various disorders such as allergy or diabetes."

The researchers then carried out data simulations of how the network model reacted to repeated exposure to particles, which resulted in four reaction patterns, one of which was to suppress th
'/>"/>

Contact: Mikael Benson
mikael.benson@vgregion.se
46-031-343-5162
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomarkers for identifying infant infections
2. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
3. Eosinophils as markers for asthma
4. Tiny samples could yield big predictive markers for pancreatic cancer
5. New tumor markers determine therapy intensity
6. Researchers identify genetic markers for aggressive head and neck cancer
7. Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection
8. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
9. Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues
10. Assessing lead time of selected ovarian cancer biomarkers
11. Pacific Biometrics, Inc. Stockholders Approve Company Name Change to Pacific Biomarkers, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... that let nerve cells send out electrical signals, Johns ... tactic that may offer a new way to protect ... responsible way. , Their findingthat naturally occurring insect ... for a closely related onesuggests that insecticides can be ... like bees. A summary of the research, led by ...
(Date:7/10/2014)... 27, 2014  The American Academy of Forensic ... Standards and Technology (NIST) and the Department of ... and forensic science expert members to the Forensic ... element of the NIST,s Organization of Scientific Area ... first appointments made to the new FSSB that ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... we,ve been told, eliminating or severely limiting fats from ... in patients suffering from heart failure, a study at ... Results from biological model studies conducted by assistant professor ... researchers, demonstrate that a high-fat diet improved overall mechanical ...
... WASHINGTON The Chesapeake Bay Program is a ... jurisdictions in the bay watershed to oversee the restoration ... the extent of pollutants -- such as nitrogen, phosphorus, ... from the National Research Council assesses the framework used ...
... a researcher at the Royal Swedish Academy of Sciences, Margareta ... permafrost. "The changes we see are dramatic. And ... from the norm when compared with a longer term perspective", ... of the globe that is warming up fastest today. Measurements ...
Cached Biology News:Damaged hearts pump better when fueled with fats 2Chesapeake Bay program's 2-year milestones improve upon past strategies, but accounting of progress remains a challenge 2A new research report shows effects of climate change in the Arctic are more extensive than expected 2A new research report shows effects of climate change in the Arctic are more extensive than expected 3
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Terascala, the ... announced that Alan Swahn, a former vice president of ... team as vice president of marketing. Terascala’s software when ... and NetApp create the highest performance and most reliable ... appointed to guide Terascala’s channel expansion and broaden its ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... has succeeded in significantly increasing the sensitivity of the ... on this topic at Delft University of Technology on ... and astronomers from around the world are currently working ... of 66 advanced telescopes which will be placed at ...
... Iceland, February 3 deCODE genetics,(Nasdaq: DCGN ) ... letter from,the Nasdaq Listing Qualifications Panel (the "Panel") stating ... stock from the Nasdaq Global,Market to the Nasdaq Capital ... Wednesday, February 4, 2009. The Nasdaq Capital Market, which ...
... DHA (docosahexaenoic acid) omega-3 innovator and maker of the ... today that it has entered into a license agreement ... is a process widely used in food manufacturing that ... the nutritional value, shelf-life and flavor of the finished ...
Cached Biology Technology:Nanotechnology makes supertelescopes much more sensitive 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 3Martek, General Mills Collaborate on Microencapsulation Technology for Food Applications 2Martek, General Mills Collaborate on Microencapsulation Technology for Food Applications 3
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Lysozyme C (W-20)...
... ventilated and BR4i refrigerated multifunction centrifuges are equally ... at a low sound level with a large ... Their AUTO-LOCK rotor exchange system without tools ensures ... within seconds. Instant rotor exchange (5 ...
... X-Gal (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) is a ... identify recombinant plasmids. In ... and IPTG, lac ... blue, whereas recombinant colonies ...
Biology Products: