Navigation Links
New marker of drug response may speed pace of lung cancer prevention trials
Date:1/8/2013

Testing medicines to prevent lung cancer requires treating many thousands of high-risk individuals and then waiting 5, 10 or 15 years to discover which of them develop cancer and which, if any, experience survival benefit from the treatment. A University of Colorado Cancer Center study recently published in the journal Cancer Prevention Research proposes a possible waypoint on the way to benefit, which if validated, could dramatically reduce the number of patients needed and time required to test drugs for lung cancer prevention.

"Chemoprevention is an important approach that has been way behind in terms of scientific advances for lung cancer," says Fred R. Hirsch, MD, PhD, investigator at the CU Cancer Center and professor of medical oncology and pathology at the CU School of Medicine. "If we could find a surrogate endpoint for lung cancer mortality an intermediate endpoint it would make it much easier to conduct smaller trials in much shorter time."

The original intent of the study was to discover certain microRNAs whose level of expression might predict patients likely to respond to the possible chemopreventive drug, Iloprost. If an especially high or low microRNA expression predicted response, it would allow researchers to test the drug only in the population most likely to benefit. Unfortunately, while levels of seven miRNAs were found to be correlated with the appearance of lung cancer, none predicted response to the drug.

It might have been a dead-end study if it weren't for microRNA-34c.

To a striking degree, changes in the expression of this molecule six months after treatment correlated with benefit from the drug seen much later. In those who later showed benefit, microRNA-34c expression was down six months after treatment; in patients who showed no benefit, microRNA-34c expression remained unchanged.

"Instead of waiting for an endpoint 15 years in the future, we could potentially discover the effe
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Is the detection of early markers of Epstein Barr virus of diagnostic value?
2. BioFortis Inc., Introduces Next Generation Biobanking Software Platform for Biomarker-Based Clinical Research
3. U of M researchers: Newly discovered genetic markers could signal colon cancer development
4. Molecular and protein markers discovered for liver transplant failure from hepatitis C
5. Color-coded markers may help doctors diagnose neural diseases through the eyes
6. New biomarker for common lung cancer predicts responses to chemotherapy
7. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
8. Researchers identify genetic markers to predict male fertility
9. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
10. Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease
11. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... moving body relies on an orchestrated response of bones, joints, ... literally the geometry of a critical part like ... just a footfall error at the root of one of ... cruciate ligament tear. In fact, size of the femoral ... and volume of the ACL combine to influence the ...
(Date:9/23/2014)... MADISON, Wis. A multidisciplinary team at the University ... creating a faster, more affordable way to screen for ... development. , The National Institutes of Health (NIH) announced ... 11 universities receiving support to continue the promising work ... program. The team will receive approximately $7 million over ...
(Date:9/23/2014)... Health will award funds to support the next phase ... improve ways of predicting drug safety and effectiveness. Researchers ... human tissue chips and combine them into an integrated ... human body. Led by the National Center for Advancing ... at $17 million in 2014 with additional support over ...
Breaking Biology News(10 mins):Does size matter? MRI imaging sheds light on athletes most at risk for severe knee injury 2Does size matter? MRI imaging sheds light on athletes most at risk for severe knee injury 3UW-Madison team developing 'tissue chip' to screen neurological toxins 2UW-Madison team developing 'tissue chip' to screen neurological toxins 3NIH funds next phase of Tissue Chip for Drug Screening program 2NIH funds next phase of Tissue Chip for Drug Screening program 3NIH funds next phase of Tissue Chip for Drug Screening program 4
... Leading scientists, physicians, and veterinarians are uncovering new links ... implications for human health. , "Marine mammals are providing ... says Paul Sandifer, Chief Scientist for the new Oceans ... and Atmospheric Administration (NOAA). "There is mounting evidence ...
... there's a constant shuffling of genetic material going ... via ocean-dwelling viruses, scientists report this week in ... Sallie Chisholm and her colleagues at the Massachusetts ... new facet of evolution and helping scientists see ...
... gene responsible for making embryos male and forming the ... by Parkinson's disease. Published in the Feb. 21 ... why more men than women develop the degenerative disorder, ... 1.5 times more likely to develop Parkinson's disease than ...
Cached Biology News:Marine mammals are on the frontline of failing ocean health 2Marine mammals are on the frontline of failing ocean health 3Marine mammals are on the frontline of failing ocean health 4Marine mammals are on the frontline of failing ocean health 5Marine mammals are on the frontline of failing ocean health 6Scientists discover interplay between genes and viruses in tiny ocean plankton 2UCLA scientists find male gene in brain area targeted by Parkinson's 2
(Date:9/23/2014)... 23, 2014 This is a ... of the Phenolic Resin industry in Global and ... industry, including definitions, applications and industry chain structure. ... are provided with a focus on history, developments, ... comparison between the international and Chinese situation is ...
(Date:9/23/2014)... ATCC, the premier global biological materials resource ... appointments to the senior leadership team. Barbie Bigelow has ... Technology and Dr. Maryellen de Mars also joins as ... roles are new positions at ATCC. ... ATCC described the additions as part of a revitalization ...
(Date:9/23/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced three ... to $5 million. The orders are all odour control projects ... continue to see new orders coming in," said Peter ... has climbed to over $11 million." About ... company that designs, manufactures and distributes a comprehensive line of ...
(Date:9/23/2014)... This is a professional and in-depth ... (IPA) industry. The report provides a basic overview ... chain structure. Global market analysis and Chinese domestic ... history, developments, trends and competitive landscape of the ... situation is also offered. , The report ...
Breaking Biology Technology:Phenolic Resin Industry (International, China) Development Policy and Plan Now Available at ReportsnReports.com 2ATCC Announces New Appointments to its Leadership Team 2ATCC Announces New Appointments to its Leadership Team 3(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 2(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 3
... ... its first relaunch, and came out as a beta. In this relaunch they have focused on ... get more relevant results. They have tried to get the users to get and give a ... , ...
... POMPEY, France, September 17 Novasep is ... - France, specialized in the development,and manufacturing of ... "Potent Compound Safety Certification" from SafeBridge(R),Consultants, Inc. , ... Safety Certification program verifies,Novasep,s performance in the management, ...
... SCOTTSDALE, Ariz., Sept. 17 MedTrust Online, a ... options for challenging patient cancer cases, has surpassed 5,000 ... Online also announced today that world-renowned oncologist Dr. Henry ... advisors. , , "5,000 users is ...
Cached Biology Technology:ePDF is Happy to Announce that ePDF has Completed its First Relaunch, and has Come Out as a Beta 2Novasep Gains SafeBridge(R) "Potent Compound Safety Certification" for its Le Mans Facility 2Novasep Gains SafeBridge(R) "Potent Compound Safety Certification" for its Le Mans Facility 3MedTrust Online Surpasses 5,000 Registered Users and Adds Dr. Henry Friedman to Oncology Advisory Board 2
... bottoms,• Nonreversible lids with ... contamination,• Individual alphanumerical codes ... footprint for ease in ... cell attachment,• Sterilized by ...
... is a G1 cyclin required for G1-phase ... a proto-oncogene. cyclin D2 can phosphorylate ... Species Reactivity: Human, Mouse, and Rat. ... is particularly well suited for neutralization of ...
... combines shaking and rocking for maximal fluid movement. ... mm stainless steel or acrylic platform, it is ... operation. The platform angle is easily adjusted from ... action and rotation speed of platform is adjusted ...
... PROTEAN II xi 2-D system runs both gel dimensions ... tube gels can be separated in a single run ... cooling core in much the same manner as the ... the second-dimension slab gels may be cast in the ...
Biology Products: