Navigation Links
New low-cost method to deliver vaccine shows promise
Date:11/15/2010

BOSTON (November 16, 2010) Researchers have developed a promising new approach to vaccination for rotavirus, a common cause of severe diarrheal disease that is responsible for approximately 500,000 deaths among children in the developing world every year. In a study published in the November issue of Clinical and Vaccine Immunology, a vaccine delivered as nasal drops effectively induced an immune response in mice and protected them from rotavirus infection. The new vaccine delivery system has also been tested successfully and found to be heat stable with tetanus and is currently being tested with diphtheria and pertussis.

The team from the Cummings School of Veterinary Medicine at Tufts University and Tufts University School of Medicine collaborated with researchers from Boston and Tulane Universities to test the effectiveness of immunization with harmless bacteria that were engineered to display rotavirus protein.

"The new vaccine, in conjunction with an agent that enhances immunity, induced sufficient antibody formation against rotavirus to protect mice against infection when the mice were exposed to rotavirus three weeks after their third immunization," explained John E. Herrmann, PhD, research professor in the infectious diseases division of the department of biomedical sciences at the Cummings School of Veterinary Medicine at Tufts University and the senior author of the published study.

"We created the rotavirus vaccine using a harmless bacterium called Bacillus subtilis (B. subtilis), which we can modify to display on its surface or in its cytoplasm proteins from infectious bacteria and viruses. When people are exposed to these proteins, they develop antibodies against them and therefore become immune to the bacteria and viruses," said the study's first author Sangun Lee, PhD, DVM, research associate at the Cummings School. "The B. subtilis bacteria are so harmless that they are part of the normal diet in several
'/>"/>

Contact: Siobhan E. Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Undergraduates low-cost ultrasound system wins Gates Foundation grant
2. Low-cost, ultra-fast DNA sequencing brings diagnostic use closer
3. Simple, low-cost steps enhance adolescents health
4. Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
5. Pilot study shows effectiveness of new, low-cost method for monitoring hand hygiene compliance
6. Cellulosic biofuel technology will generate low-cost green fuel, says major study
7. High Performance, Low-Cost VoIP Chips Address Critical Performance Issues Such as Echo, Latency, and Packet Loss
8. Fast-track gene-ID method speeds rare disease search
9. OU study on genetics in fruit flies leads to new method for understanding brain function
10. New method successfully predicted how oil from Deepwater Horizon spill would spread
11. University at Buffalo symposium on in silico methods, high throughput screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New low-cost method to deliver vaccine shows promise
(Date:1/22/2015)... , Jan. 22, 2015   EyeLock, Inc. , a ... has appointed Steve Gerber to the new role ... be responsible for leading development of mobile platforms and wearable ... of success and innovation in the semiconductor industry to his ...
(Date:12/22/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ... "The Global Watermarking and Fingerprinting Markets" report ... http://photos.prnewswire.com/prnh/20130307/600769 This insight provides an ... fingerprinting markets. Watermarking aims to control and monitor ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2The Global Watermarking and Fingerprinting Markets 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... medical device currently used for intestinal research, the colonsope, ... method has been developed, inspired by the way in ... received her PhD degree from TU Delft based on ... extremely difficult area to navigate through with a medical ...
... drug tamoxifen (Nolvadex®), which can become less effective over ... along with a second drug, according to new research ... Institute (NCI), part of the National Institutes of Health, ... 11, 2006, issue of Cancer Cell*. , Tamoxifen has ...
... Herceptin is borne by other patients whose treatment has to ... week’s BMJ. , New guidance from the National Institute for ... breast cancer, but it provides no extra funding and does ... extra money. This leaves medical staff with difficult decisions to ...
Cached Biology News:Like a snail through the intestinal canal 2Restoring tamoxifen sensitivity in resistant breast cancer cells 2Other patients bear the real cost of Herceptin 2
(Date:1/22/2015)... Pipette.com has added the Eppendorf Centrifuge ... of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 R ... R and receive the following:, ,     Free ... Eppendorf Reference 2 ,     3 Free boxes ...
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)... 22. 2015  Varian Medical Systems (NYSE: VAR ), ... for its commitment to sustainability with inclusion on a prestigious ... highest ranked healthcare equipment company among the Corporate Knights Global ... Economic Forum at Davos, Switzerland . ...
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... Tech provides veteran business leadership to deliver new ideas to market. ... ... www.lgeexecs.com [LGE Execs], an Austin based firm formed to ... agreement with the Texas Tech University System (TTUS). The agreement will ...
... - Dr. Yong Shi of Stevens Institute of ... his project titled "MEMS Umbrella-Shaped Actuator with Active ... on scientific/technical merit for three years and will ... is to design, fabricate and test an umbrella-shaped ...
... SAN FRANCISCO, Calif., Sept. 2 Anesiva,Inc. (Nasdaq: ... M.D. has joined,the company as senior vice president ... clinical and regulatory functions., "Bill brings to ... management products, and a medical background in,anesthesiology," said ...
Cached Biology Technology:LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences 2LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences 3Dr. Yong Shi awarded NSF grant 2Anesiva Announces Appointment of William Houghton, M.D. as Senior Vice President and Chief Medical Officer 2
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... cell culture scale-up, these culture chambers produce ... 10 9 range and are useful ... flasks. • High mechanical • strength and ... to shipping • Certified nonpyrogenic and sterilized ...
Mouse monoclonal antibody to QARS - glutaminyl-tRNA synthetase...
... recombinant thermostable DNA polymerase obtained by high ... gene in E. coli, Concentration: 5U/ul, Applications: ... Fisher Scientific, the world leader in serving ... make the world healthier, cleaner and safer ...
Biology Products: