Navigation Links
New link in liver cancer
Date:3/30/2009

Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis. In severe cases, this damage can lead to cancer. A new study by researchers at the National Institutes of Health and Osaka University reveals how one protein helps decide the fate of damaged livers in mice. The study will be published online on March 30th in the Journal of Experimental Medicine.

Liver cells rely on signals triggered by growth hormone to survive and multiplyfunctions that go haywire in cancer. Normally, growth hormone works by activating a signaling network inside liver cells that includes a protein called STAT5. When the researchers removed STAT5 from liver cells, cancer ensued.

The normally protective effect of STAT5 was traced to its ability to hitch itself to a damage-inducing protein called TGFbeta and trigger its destruction. Without STAT5, TGFbeta levels soared, and growth hormone activated a related protein, STAT3, which is known to promote tumor growth.

TGFbeta and STAT5 appear to be adversaries in the liver, according to the study. STAT5 protects the liver by breaking down TGFbeta. But when TGFbeta is abundantas occurs in people with chronic liver damagegrowth hormone activates the cancer-promoting STAT3 instead of the protective STAT5. These results might help explain how chronic liver damage can eventually lead to cancer.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Difference in fat storage may explain lower rate of liver disease in African-Americans
2. Researchers identify gene linked to aggressive progression of liver cancer
3. Apple or pear shape is not main culprit to heart woes -- its liver fat
4. New type of vaccines deliver stronger and faster immune response
5. Toxic bile damages the liver
6. Depression during pregnancy can double risk of preterm delivery
7. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
8. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
9. Resveratrol prevents fat accumulation in livers of alcoholic mice
10. RNA molecules, delivery system improve vaccine responses, effectiveness
11. Sig-Tec(R) and BIO-key(R) Deliver Advanced Biometric Security Solution to Ohio County Law Enforcement Agency
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New link in liver cancer
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ...
(Date:12/17/2014)... BELVOIR, Va. , Dec. 15, 2014 The ... it easier to detect and prevent counterfeit microcircuits from ... agency started performing an in-house microcircuit anti-counterfeit initiative dubbed ... purchased microcircuits while increasing their reliability throughout the supply ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... sandpipers ( Calidris pusilla ) feeding during low tide ... Beauchamp, an ornithologist and research officer at the University ... the periphery remained alert and used short pecks to ... the group relaxed their vigilance and fed on a ...
... are the heart of the smaller, better electronics ... new materials, medical diagnostics and therapeutics, energy storage, ... have unintended consequences for human health and the ... and policy makers, the Virginia Tech Center for ...
... long lasting, possibly permanent, performance-enhancing effects, shows a study ... Physiology ., Previously, re-acquisition of muscle mass with ... has been attributed to motor learning. However, this new ... is a cellular ,memory mechanism, within muscle of brief ...
Cached Biology News:Bird buffet requires surveillance 2Nanomaterials database improved to help consumers, scientists track products 2Nanomaterials database improved to help consumers, scientists track products 3Nanomaterials database improved to help consumers, scientists track products 4
(Date:1/22/2015)... Selexis SA, a serial innovation company with ... used for drug discovery to commercial manufacturing, announced today ... Next-Generation Sequencing (NGS) data packages. The NGS analysis ... ensuring the integrity of the gene, validation of the ...
(Date:1/22/2015)... GenoSpace , a precision medicine software company that has developed ... of genomic, imaging and other biomedical data in research and ... , CEO of Aspera, an IBM Company, to its board ... "We are pleased to welcome Michelle ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 24, 2014  Vermillion, ... focused on gynecologic disease, announced today that the ... investors including Oracle Investment Management, Jack W. ... directors. Total proceeds were $10.5 million, before offering ...
(Date:12/24/2014)... 23, 2014 SoundConnect’s ... introduce cutting edge communication technology, provide continued education ... This webinar series demonstrates online communication features and ... web conferencing’s most innovative and powerful tools. , ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... - Worldwide Net Revenue Increased 4% for the 2008 Third Quarter and ... - Third Quarter Revenue Growth in Pharmaceuticals Division Led by ... and Prevnar +13% , - Guidance for 2008 Full ... Items, Revised to a Range of $3.49 to $3.55 , ...
... - Updated Results Presented at 20th EORTC-NCI-AACR ... and GENEVA, Oct. 22 /PRNewswire-FirstCall/,-- Poniard Pharmaceuticals, ... focused on oncology, today announced positive incremental ... of picoplatin in combination with,docetaxel and prednisone ...
... of Health, SAN DIEGO, Oct. 22 ... $28 million contract from the National Institute,of Allergy ... National,Institutes of Health, for the development of novel ... five-year,contract, Trius will develop novel drugs targeting bacterial ...
Cached Biology Technology:Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 2Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 3Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 4Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 5Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 6Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 7Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 8Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 9Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 10Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 11Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 12Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 13Wyeth Reports Earnings Results for the 2008 Third Quarter and First Nine Months 14Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 2Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 3Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 4Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 5Trius Awarded $28 Million Contract to Develop Novel Antibiotics 2
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... Super Sensitive MultiLink IHC Detection ... secondary antibodies, labeled with multiple ... the bound primary antibody, and ... Streptavidin-Enzyme conjugate. This kit is ...
BioGenex IHC Kits for Rodent Tissues are designed for immunohistochemistry on rodent and rabbit tissues that are closely related to the source of the primary antibody. This kit comes with rat seconda...
Dual-bay Dyad thermal cycler chassis, does not include the Alpha units (requires 2)...
Biology Products: