Navigation Links
New link in liver cancer
Date:3/30/2009

Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis. In severe cases, this damage can lead to cancer. A new study by researchers at the National Institutes of Health and Osaka University reveals how one protein helps decide the fate of damaged livers in mice. The study will be published online on March 30th in the Journal of Experimental Medicine.

Liver cells rely on signals triggered by growth hormone to survive and multiplyfunctions that go haywire in cancer. Normally, growth hormone works by activating a signaling network inside liver cells that includes a protein called STAT5. When the researchers removed STAT5 from liver cells, cancer ensued.

The normally protective effect of STAT5 was traced to its ability to hitch itself to a damage-inducing protein called TGFbeta and trigger its destruction. Without STAT5, TGFbeta levels soared, and growth hormone activated a related protein, STAT3, which is known to promote tumor growth.

TGFbeta and STAT5 appear to be adversaries in the liver, according to the study. STAT5 protects the liver by breaking down TGFbeta. But when TGFbeta is abundantas occurs in people with chronic liver damagegrowth hormone activates the cancer-promoting STAT3 instead of the protective STAT5. These results might help explain how chronic liver damage can eventually lead to cancer.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Difference in fat storage may explain lower rate of liver disease in African-Americans
2. Researchers identify gene linked to aggressive progression of liver cancer
3. Apple or pear shape is not main culprit to heart woes -- its liver fat
4. New type of vaccines deliver stronger and faster immune response
5. Toxic bile damages the liver
6. Depression during pregnancy can double risk of preterm delivery
7. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
8. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
9. Resveratrol prevents fat accumulation in livers of alcoholic mice
10. RNA molecules, delivery system improve vaccine responses, effectiveness
11. Sig-Tec(R) and BIO-key(R) Deliver Advanced Biometric Security Solution to Ohio County Law Enforcement Agency
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New link in liver cancer
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... Linda, Ca (PRWEB) , ... August 15, 2017 ... ... coffee production and is threatened by various biotic and abiotic factors. During this ... complex evolutionary history of coffee, as well as gain a better understanding of ...
(Date:8/14/2017)... , ... August 14, 2017 , ... ... essential device-to-computer interconnect using USB or PCI Express, announced the release of SYZYGY™, ... is intended to satisfy the need for a compact, low cost, low pin-count, ...
(Date:8/11/2017)... San Antonio, Texas (PRWEB) , ... August 11, 2017 , ... ... launching a rebranding campaign this month that will incorporate important key elements including a ... to thank the community that has supported them, Bill Miller has partnered with the ...
(Date:8/10/2017)... ... August 09, 2017 , ... As a full-service marketing agency, ... customers with the right message. Their effective, cutting-edge inbound marketing strategies are available ... how crucial the agriculture industry is,” said David Phelps, chief marketing officer at ...
Breaking Biology Technology: