Navigation Links
New link in liver cancer
Date:3/30/2009

Liver damage can be triggered by various insults, including hepatitis infection or alcohol-induced cirrhosis. In severe cases, this damage can lead to cancer. A new study by researchers at the National Institutes of Health and Osaka University reveals how one protein helps decide the fate of damaged livers in mice. The study will be published online on March 30th in the Journal of Experimental Medicine.

Liver cells rely on signals triggered by growth hormone to survive and multiplyfunctions that go haywire in cancer. Normally, growth hormone works by activating a signaling network inside liver cells that includes a protein called STAT5. When the researchers removed STAT5 from liver cells, cancer ensued.

The normally protective effect of STAT5 was traced to its ability to hitch itself to a damage-inducing protein called TGFbeta and trigger its destruction. Without STAT5, TGFbeta levels soared, and growth hormone activated a related protein, STAT3, which is known to promote tumor growth.

TGFbeta and STAT5 appear to be adversaries in the liver, according to the study. STAT5 protects the liver by breaking down TGFbeta. But when TGFbeta is abundantas occurs in people with chronic liver damagegrowth hormone activates the cancer-promoting STAT3 instead of the protective STAT5. These results might help explain how chronic liver damage can eventually lead to cancer.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Difference in fat storage may explain lower rate of liver disease in African-Americans
2. Researchers identify gene linked to aggressive progression of liver cancer
3. Apple or pear shape is not main culprit to heart woes -- its liver fat
4. New type of vaccines deliver stronger and faster immune response
5. Toxic bile damages the liver
6. Depression during pregnancy can double risk of preterm delivery
7. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
8. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
9. Resveratrol prevents fat accumulation in livers of alcoholic mice
10. RNA molecules, delivery system improve vaccine responses, effectiveness
11. Sig-Tec(R) and BIO-key(R) Deliver Advanced Biometric Security Solution to Ohio County Law Enforcement Agency
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New link in liver cancer
(Date:11/21/2016)... 2016   Neurotechnology , a provider of ... announced that the MegaMatcher On Card fingerprint matching ... the NIST Minutiae Interoperability Exchange (MINEX) III ... steps of the evaluation protocol. ... of fingerprint templates used to establish compliance of ...
(Date:11/16/2016)... SANTA CLARA, Calif. , Nov. 16, 2016 /PRNewswire/ ... company enhancing user experience and security for consumer ... provider for the financial and retail industry, today ... more secure and convenient way to authenticate users ... now uses Sensory,s TrulySecure™ software which ...
(Date:11/14/2016)... SANTA CLARA, Calif. , Nov. 14, ... of the biometric identification market, Frost & ... Global Frost & Sullivan Award for Visionary ... leading player in the biometric identification market ... a multi-modal verification solution for instant, seamless, ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... ... December 05, 2016 , ... In anticipation of AxioMed’s ... disc production, company President, Jake Lubinski will be traveling to Germany on December ... in Cologne and Karlsruhe to discuss the benefits of a viscoelastic total disc ...
(Date:12/5/2016)... -- NxGen MDx announced today that it brought its NxGen Informed Prenatal ... able to improve customer service through shortened turnaround times and at the ... CEO of NxGen MDx. ... A decrease in turnaround times by 25% ... opportunities at the Grand Rapid headquarters. The NxGen Informed Prenatal ...
(Date:12/4/2016)... ... December 02, 2016 , ... A proposed five-year extension ... federally funded research and development is welcome news for the photonics community, say ... , As part of the National Defense Authorization Act (NDAA) compromise agreement finalized ...
(Date:12/2/2016)... ... December 02, 2016 , ... In anticipation of ... lumbar disc production, company President, Jake Lubinski will be traveling to Switzerland from ... disc in Bern, Lucerne, and Zurich to discuss the benefits of a viscoelastic ...
Breaking Biology Technology: