Navigation Links
New link identified for bipolar disorder
Date:6/17/2010

Lithium has been established for more than 50 years as one of the most effective treatments for manic depression, clinically termed bipolar disorder.

However, scientists have never been entirely sure exactly why it is beneficial.

Now, new research from Cardiff University scientists suggests a possible mechanism for why Lithium works, opening the door for better understanding of the illness and potentially more effective treatments.

Laboratory studies with cells have shown that an enzyme known as prolyl oligopeptidase (PO) controls a set of genes that determine sensitivity to lithium. Among these genes is ImpA2, which like PO activity itself, has been associated with differences in some bipolar patients. These results reveal a new mechanistic link that could explain these changes in these patients.

Professor Adrian Harwood of Cardiff School of Biosciences, who led the research, said: "We still cannot say definitively how lithium can help stabilise bipolar disorder. However, our research has uncovered a new cell signalling process with links to bipolar disorder.

"This introduces a new mechanism and more candidate genes whose study could lead to greater understanding of the causes of bipolar disorder, better diagnostic tests and new types of drugs that are more effective and have fewer side effects than Lithium does at present."

The research, funded by the Wellcome Trust, is published in the international journal PLoS ONE.


'/>"/>

Contact: Stephen Rouse
Rouses@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Page: 1

Related biology news :

1. Key mechanism identified in metastatic breast cancer
2. Biological link between stress, anxiety and depression identified for the first time
3. New genetic risk factors for aneurysms identified by Yale-led team
4. Autism susceptibility genes identified
5. Structure of insulins docking point identified
6. Newly identified growth factor promotes stem cell growth, regeneration
7. Cell of origin identified for common type of breast cancer
8. Genetic risk factor identified for Parkinsons disease
9. Canine compulsive disorder gene identified
10. Canine compulsive disorder gene identified in dogs
11. Genetic causes identified for disturbances in lipid metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
Breaking Biology News(10 mins):
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
(Date:6/23/2016)... ... , ... STACS DNA Inc., the sample tracking software company, today announced that ... joined STACS DNA as a Field Application Specialist. , “I am thrilled that ... of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings ...
Breaking Biology Technology: