Navigation Links
New leads on the causes of alcoholism
Date:4/4/2011

In order to develop new medications for alcoholism, researchers need to understand how alcohol acts on the brain's reward system. A previously unknown mechanism has been shown to block the rewarding effects of alcohol on the brain, reveals a thesis from the University of Gothenburg, Sweden.

Research has shown that the glycine receptor in the brain's reward system plays a role in the development of alcoholism. This receptor normally acts as a brake on the brain's communication, and has previously been shown to be heavily implicated in the transmission of pain and in epilepsy. However, this thesis and previous results from the research group at the Department of Psychiatry and Neurochemistry have shown that the glycine receptor also plays a major role in alcoholism.

Acamprosate is found in an existing medicine for reducing relapses in alcoholics. Unfortunately, this type of medicine works for some patients only and there is a real need for new, more effective medication.

"We've chosen to clarify the role of acamprosate in the process and to find out whether this can help us understand how alcohol functions in the brain's reward system," says researcher PeiPei Chau from the Sahlgrenska Academy's Department of Psychiatry and Neurochemistry.

In animal trials with rats, the researchers have seen that acamprosate activates the glycine receptors, so inhibiting the rewarding effects of alcohol, and that it is through this mechanism that acamprosate reduces alcohol consumption.

"We've identified a brand new mode of action in an existing medicine, and this helps us to understand better why alcohol dependency can arise in the brain," says Chau. "Our results also consolidate the group's previous results which showed that glycine receptors can play a major role in the development of new medicines to treat alcohol dependency."


'/>"/>

Contact: PeiPei Chau
peipei.chau@neuro.gu.se
46-031-786-3919
University of Gothenburg
Source:Eurekalert

Page: 1

Related biology news :

1. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
2. How neuronal activity leads to Alzheimers protein cleavage
3. Exposing chicks to maternal stress leads to long-term reproductive success
4. TECNALIA leads five projects within the VII Framework Program
5. Personalized medicine: Innovative online journal leads the way
6. Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
7. Study of placenta unexpectedly leads to cancer gene
8. Game of two halves leads to brain asymmetry
9. Transportation fuels of the future: Nottingham leads the way
10. Concordia University leads academic team for national Cellulosic Biofuels Network
11. Elephant shark genome sequence leads to discovery of color perception in deep-sea fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2017)... MATEO, Calif. , March 6, 2017 /PRNewswire/ ... marketing and sales technology, today announced Predictive Sales ... solution for infusing actionable sales intelligence into Salesforce. ... to automatically enable their sales organizations with deep ... messages that allow for intelligent engagement. Predictive Sales ...
(Date:3/2/2017)... LONDON , March 2, 2017 Who ... infringement lawsuits? Download the full report: https://www.reportbuyer.com/product/4313699/ ... ON THE FINGERPRINT SENSOR FIELD? Fingerprint sensors using ... smartphones. The fingerprint sensor vendor Idex forecasts an increase ... in mobile devices and of the fingerprint sensor market ...
(Date:2/28/2017)... --  Acuant , a leading provider of data capture ... new and core technologies building upon the acquisition of ... desktop Acuant FRM TM facial recognition and match ... manual review of identity documents by accredited professionals. ... most accurate capture software to streamline workflows by securely ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... 2017  Vermillion, Inc. (NASDAQ: VRML), a bio-analytical ... its results for the fourth quarter and full ... marked a pivotal year for us with our ... distribution agreements, major reimbursement progress with Medicare, positive ... In addition we cleared our 2 nd ...
(Date:3/29/2017)... 29, 2017 /PRNewswire/ - Last year,s petition to the White ... only efforts active to generate awareness on the importance of new ... in the healthcare market place. ... Earlier this month Health Advance (OTC ... pharmaceutical and nutritional products, announced its endeavors on this generally ...
(Date:3/29/2017)... ... 29, 2017 , ... (March 29, 2017) — Nerium ... as an active member of the Mexican Direct Selling Association A.C. (AMVD ... in relationship marketing. This professional organization fosters loyal and fair competition among companies ...
(Date:3/29/2017)... March 29, 2017  Halozyme Therapeutics, Inc. (NASDAQ: ... drug-delivery therapies, today announced that an Oncologic Drug ... Administration voted 11 to 0 that the benefit/risk ... was favorable for patients in the proposed indications ... chronic lymphocytic leukemia. The FDA action date is ...
Breaking Biology Technology: