Navigation Links
New leads on the causes of alcoholism
Date:4/4/2011

In order to develop new medications for alcoholism, researchers need to understand how alcohol acts on the brain's reward system. A previously unknown mechanism has been shown to block the rewarding effects of alcohol on the brain, reveals a thesis from the University of Gothenburg, Sweden.

Research has shown that the glycine receptor in the brain's reward system plays a role in the development of alcoholism. This receptor normally acts as a brake on the brain's communication, and has previously been shown to be heavily implicated in the transmission of pain and in epilepsy. However, this thesis and previous results from the research group at the Department of Psychiatry and Neurochemistry have shown that the glycine receptor also plays a major role in alcoholism.

Acamprosate is found in an existing medicine for reducing relapses in alcoholics. Unfortunately, this type of medicine works for some patients only and there is a real need for new, more effective medication.

"We've chosen to clarify the role of acamprosate in the process and to find out whether this can help us understand how alcohol functions in the brain's reward system," says researcher PeiPei Chau from the Sahlgrenska Academy's Department of Psychiatry and Neurochemistry.

In animal trials with rats, the researchers have seen that acamprosate activates the glycine receptors, so inhibiting the rewarding effects of alcohol, and that it is through this mechanism that acamprosate reduces alcohol consumption.

"We've identified a brand new mode of action in an existing medicine, and this helps us to understand better why alcohol dependency can arise in the brain," says Chau. "Our results also consolidate the group's previous results which showed that glycine receptors can play a major role in the development of new medicines to treat alcohol dependency."


'/>"/>

Contact: PeiPei Chau
peipei.chau@neuro.gu.se
46-031-786-3919
University of Gothenburg
Source:Eurekalert

Page: 1

Related biology news :

1. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
2. How neuronal activity leads to Alzheimers protein cleavage
3. Exposing chicks to maternal stress leads to long-term reproductive success
4. TECNALIA leads five projects within the VII Framework Program
5. Personalized medicine: Innovative online journal leads the way
6. Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
7. Study of placenta unexpectedly leads to cancer gene
8. Game of two halves leads to brain asymmetry
9. Transportation fuels of the future: Nottingham leads the way
10. Concordia University leads academic team for national Cellulosic Biofuels Network
11. Elephant shark genome sequence leads to discovery of color perception in deep-sea fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
(Date:4/28/2016)... GOTHENBURG, Sweden , April 28, 2016 ... 1,491.2 M (139.9), up 966% compared with the first quarter of ... Operating profit totaled SEK 589.1 M (loss: 18.8) and the operating ... SEK 7.12 (loss: 0.32) Cash flow from operations was ... , The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... -- Elekta is pleased to announce that ... treatment planning software, is available for clinical release. Real-world ... version 5.11 provides significant performance speed enhancements over prior ... four times faster than in previous versions of ... Monte Carlo algorithm, users can ...
(Date:4/28/2016)... ... April 28, 2016 , ... Next week ... talk on its first-in-class technologies for tissue stem cell counting and expansion to ... Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, Massachusetts. , The attention ...
(Date:4/27/2016)... ... 2016 , ... Shimadzu Scientific Instruments (SSI) will be showcasing ... Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for ... stop by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC ...
(Date:4/27/2016)... Md. and RESEARCH TRIANGLE PARK, ... Corporation (NASDAQ: UTHR ) announced today that ... Officer, of United Therapeutics will provide an overview and ... 41 st Annual Health Care Conference. ... 2016, at 10:00 a.m. Eastern Time, and can be ...
Breaking Biology Technology: