Navigation Links
New leads on mechanisms that confer virulence to E.coli-type bacteria
Date:12/9/2011

The researchers have solved the three-dimensional structure of a key region of the DNA-protein complex. Knowledge about the structures that control the activity of genes associated with virulence and resistance to antibiotics is crucial to understand the molecular mechanisms that regulate bacterial pathogenicity and to pave the way for alternative treatments to conventional antibiotics. According to Jess Garca, research associate in the IRB Barcelona group headed by Miquel Pons, researcher at IRB Barcelona and professor of the UB, "a strategy based on selective regulatory systems for genes responsible for virulence is particularly attractive because it could potentially minimize the adverse effects on our bacterial flora and reduce the selective pressure for the development of antibiotic resistance in bacteria".

Many of the genes responsible for pathogenic bacteria virulence and resistance to antibiotics have been acquired through processes such as horizontal gene transfer (HGT). By means of this mechanism, bacteria incorporate genetic material from external sources such as bacteria or phages (viruses that affect bacteria). The correct regulation of HGT genes, in other words silencing when not required and coordinated activation to produce a beneficial effect, is crucial for the success of bacteria.

"The resolved structure has allowed us to understand the way in which Ler recognizes its DNA binding sites. Ler does not recognize specific sequences but local DNA structures. In our study we also tested whether this recognition mode is used by other proteins of the same family, such as H-NS", explains Garca. The Ler and H-NS proteins play a critical role in the regulation of genes acquired through HGT in pathogenic E. coli strains.


'/>"/>
Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1

Related biology news :

1. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
2. How neuronal activity leads to Alzheimers protein cleavage
3. Exposing chicks to maternal stress leads to long-term reproductive success
4. TECNALIA leads five projects within the VII Framework Program
5. Personalized medicine: Innovative online journal leads the way
6. Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
7. Study of placenta unexpectedly leads to cancer gene
8. Game of two halves leads to brain asymmetry
9. Transportation fuels of the future: Nottingham leads the way
10. Concordia University leads academic team for national Cellulosic Biofuels Network
11. Elephant shark genome sequence leads to discovery of color perception in deep-sea fish
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New leads on mechanisms that confer virulence to E.coli-type bacteria
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... UAS LifeSciences, one of the leading manufacturers ... Probiotics, into Target stores nationwide. The company, which has been manufacturing high quality ... list of well-respected retailers. This list includes such fine stores as Whole Foods, ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
Breaking Biology Technology: