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New knowledge on the pharmacology of dopamine stabilizers
Date:2/24/2012

ophrenia. However, in a study published recently in the scientific journal Molecular Psychiatry, researchers at Karolinska Institutet have shown that ACR16 and another dopamine stabiliser (-)-OSU6162 also bind to the sigma-1 receptor in low concentrations.

"We found that ACR16 binds to the sigma-1 receptor at concentrations 100 times lower than those reported for interaction with the D2 receptor," says Dr Marcellino. "This is extremely interesting since experimental studies have shown that sigma-1 receptor ligands have positive effects in schizophrenia and protect against cell death in neurodegenerative conditions."


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Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

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