Navigation Links
New knowledge on the pharmacology of dopamine stabilizers
Date:2/24/2012

A study from Karolinska Institutet in Sweden shows that a new drug for Huntington's disease pridopidine or dopamine stabiliser ACR16 might operate via previously unknown mechanisms of action. Researchers have found that at very low concentrations, ACR16 binds to the sigma-1 receptor, a protein in the brain important to neuronal function and survival. This new knowledge can be used to develop future treatments for schizophrenia, involuntary Parkinsonian tremors and neurodegenerative diseases.

"It's conceivable that some of the beneficial effects of dopamine stabilisers are mediated via the sigma-1 receptor," says principal investigator Daniel Marcellino of the Department of Neuroscience. "Our results suggest a formerly overlooked aspect of dopamine stabiliser pharmacology."

Dopamine stabilisers are a new class of drug substance originally developed by Swedish Nobel laureate Professor Arvid Carlsson. In clinical trials, these substances have revealed promising results against neurological and neuropsychiatric conditions that currently lack suitable treatment, such as schizophrenia and the dyskinesia (involuntary tremors) caused as an adverse effect of Parkinson's drugs.

Pridopidine or dopamine stabiliser ACR16 (also known as Huntexil), is in an advanced phase of clinical trials (phase III) for the relief of the motor symptoms of Huntington's disease, an incurable disease caused by neuronal degeneration in certain parts of the brain. The disease, which is hereditary, is characterised by motor and subsequent psychiatric disorders, leading to a protracted death. There is currently only one drug registered for the relief of Huntington's symptoms, but as it has several adverse effects there is a strong demand for alternative treatment options.

Dopamine stabilisers are thought to exert their beneficial effects primarily via the dopamine D2 receptor, which is a well-known site of action for drugs for Parkinson's disease and schiz
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Closing the gap: Journal launch brings together wound-healing knowledge
2. New scientific knowledge on juvenile diabetes
3. Researchers advance knowledge of little nano-machines in our body
4. Wallace S. Broecker wins the BBVA Foundation Frontiers of Knowledge Award in Climate Change
5. Federal scientists recognized for contributions to knowledge of bird ecology and habitat
6. Village bird study highlights loss of wildlife knowledge from one
7. German Research Minister Schavan: Rapid knowledge transfer can safe lives
8. The BBVA Foundation presents its Frontiers of Knowledge Awards
9. Peter Reich, BBVA Foundation Frontiers of Knowledge Award in Ecology
10. Studies improve knowledge of underlying brain changes caused by addiction
11. Technique finds gene regulatory sites without knowledge of regulators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Knowing what causes them at the molecular level is ... have created the most detailed map to date of ... blinding diseases, such as age-related macular degeneration. The high-resolution ... which supplies blood and oxygen to the outer retina, ... abundance of proteins in different areas of the choroid, ...
(Date:8/1/2014)... the conductive tissue through which plants transport carbohydrates and ... are capped at one end by a sieve plate ... turn form a network throughout a plant,s body. ... play an important role in carbon sequestration, yet so ... says Professor Yk Helariutta from the Institute of Biotechnology, ...
(Date:8/1/2014)... most diverse families in the ocean today -- marine ... more than 400 million years ago in the Silurian ... its modern members. This Geology study by ... on 25 July 2014, tracks the remarkable evolutionary expansion ... is origin, the Lucinidae family remained at very low ...
Breaking Biology News(10 mins):A map for eye disease 2Developmental regulation of important plant phloem components discovered 2Symbiotic survival 2Symbiotic survival 3Symbiotic survival 4Symbiotic survival 5Symbiotic survival 6Symbiotic survival 7Symbiotic survival 8Symbiotic survival 9Symbiotic survival 10Symbiotic survival 11Symbiotic survival 12Symbiotic survival 13Symbiotic survival 14
... Since its discovery in the 18th century, cocaine has ... reward centres in low doses, cocaine is extremely addictive ... potent compound did not evolve to ensnare humans in ... cocaine is a powerful insect neurotoxin, protecting coca bushes ...
... WA This Christmas season, think twice about spending ... tree. The good, old-fashioned methodkeeping your tree in a ... keep your tree green and healthy. Researchers have determined ... trees; in fact, in several cases the chemical retardants ...
... LANSING, Mich. Diversity is valuable socially, economically and ... has found that growing more corn to produce ethanol ... of beneficial insects to control pests, a loss valued ... states studied (Michigan, Iowa, Minnesota and Wisconsin). "Corn ...
Cached Biology News:Honeybees succumb to cocaine's allure 2Flame retardants prove ineffective on fresh-cut Christmas trees 2Diverse landscapes are better: Policymakers urged to think broadly about biofuel crops 2
(Date:8/1/2014)... As one of the 10 largest medical ... & Clinical Lab Expo is the place where breakthrough ... to the healthcare world. This year, many of the ... include the latest diagnostic technology in the field of ... biosensors have enabled the development of "labs-on-a-chip" that can ...
(Date:8/1/2014)... Research and Markets has announced the addition ... and Analysis Market 2014-2018" report to their offering. ... Single Nucleotide Polymorphism (SNP) genotyping is the screening and ... of various species. SNPs are commonly present in all ... analyze thousands of SNPs and has the potential for ...
(Date:8/1/2014)... Testing the mechanical properties of ... understanding embryonic development. How and why embryonic ... functionally distinct tissues is important because abnormalities can ... McDevitt, Melissa Kinney, and Rabbia Saeed worked from ... cues to control many aspects of embryo development. ...
(Date:7/31/2014)... a good reason people over 60 are not donor ... and weakens with time, making the elderly prone to ... Francisco research team now has discovered a reason why. ... the inability of blood-forming cells to maintain blood production ... molecular defects that could be restored for rejuvenation therapies," ...
Breaking Biology Technology:Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market 2014-2018 2Study Links Biomechanics and Gene Expression in Stem Cells 2Key to aging immune system is discovered 2
... Calif., Oct. 15 ... INKN ), an innovative nanotechnology company developing ... industry, medical diagnostics and sensors and biotechnology research ... its first product offering – the StemDisc450™, a ...
... NORWALK, Conn., Oct. 15 UBM Medica today announces ... ) from MediSpecialty.com, Inc.   OBGYN.net is ... and patients.  The site provides article-based and multimedia content ... online forums – some of which have been running ...
... CoreLab Partners, Inc , the global entity resulting ... in February of this year, has launched a full ... as it relates to Dual Energy X-Ray Absorptiometry ( ... that we have formally launched state-of-the-art imaging solutions to ...
Cached Biology Technology:Shrink Nanotechnologies Unveils Product Image of Initial StemDisc450 Prototype 2Shrink Nanotechnologies Unveils Product Image of Initial StemDisc450 Prototype 3Shrink Nanotechnologies Unveils Product Image of Initial StemDisc450 Prototype 4UBM Medica Acquires Leading Online Community OBGYN.net 2UBM Medica Acquires Leading Online Community OBGYN.net 3CoreLab Partners Launches New DXA Imaging Service Offerings 2
... Dako Target Retrieval Solution, pH 9 ... Tris/EDTA buffer, pH 9, intended for heat-induced ... It is well-suited for use on formalin-fixed, ... Compared with 0.01 mol/L citrate buffer, pH ...
... White to off-white solid. Increases the expression of ... Soluble in H 2 O. Unstable in ... RTECS EK7713840, CAS 3211-76-5, M.W. 196.1. References: ... L., and Junod, A.F. 1995. Biochem. J. ...
... antifade reagent is used to ... standard fluorescence microscopy. The unique ... a wide variety of fixed ... fluorescein, rhodamine, sulforhodamine 101, coumarin, ...
...
Biology Products: