Navigation Links
New knowledge on the pharmacology of dopamine stabilizers
Date:2/24/2012

A study from Karolinska Institutet in Sweden shows that a new drug for Huntington's disease pridopidine or dopamine stabiliser ACR16 might operate via previously unknown mechanisms of action. Researchers have found that at very low concentrations, ACR16 binds to the sigma-1 receptor, a protein in the brain important to neuronal function and survival. This new knowledge can be used to develop future treatments for schizophrenia, involuntary Parkinsonian tremors and neurodegenerative diseases.

"It's conceivable that some of the beneficial effects of dopamine stabilisers are mediated via the sigma-1 receptor," says principal investigator Daniel Marcellino of the Department of Neuroscience. "Our results suggest a formerly overlooked aspect of dopamine stabiliser pharmacology."

Dopamine stabilisers are a new class of drug substance originally developed by Swedish Nobel laureate Professor Arvid Carlsson. In clinical trials, these substances have revealed promising results against neurological and neuropsychiatric conditions that currently lack suitable treatment, such as schizophrenia and the dyskinesia (involuntary tremors) caused as an adverse effect of Parkinson's drugs.

Pridopidine or dopamine stabiliser ACR16 (also known as Huntexil), is in an advanced phase of clinical trials (phase III) for the relief of the motor symptoms of Huntington's disease, an incurable disease caused by neuronal degeneration in certain parts of the brain. The disease, which is hereditary, is characterised by motor and subsequent psychiatric disorders, leading to a protracted death. There is currently only one drug registered for the relief of Huntington's symptoms, but as it has several adverse effects there is a strong demand for alternative treatment options.

Dopamine stabilisers are thought to exert their beneficial effects primarily via the dopamine D2 receptor, which is a well-known site of action for drugs for Parkinson's disease and schiz
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Closing the gap: Journal launch brings together wound-healing knowledge
2. New scientific knowledge on juvenile diabetes
3. Researchers advance knowledge of little nano-machines in our body
4. Wallace S. Broecker wins the BBVA Foundation Frontiers of Knowledge Award in Climate Change
5. Federal scientists recognized for contributions to knowledge of bird ecology and habitat
6. Village bird study highlights loss of wildlife knowledge from one
7. German Research Minister Schavan: Rapid knowledge transfer can safe lives
8. The BBVA Foundation presents its Frontiers of Knowledge Awards
9. Peter Reich, BBVA Foundation Frontiers of Knowledge Award in Ecology
10. Studies improve knowledge of underlying brain changes caused by addiction
11. Technique finds gene regulatory sites without knowledge of regulators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... business incubator, received a $1.4 million federal grant to ... staunch bleeding during brain surgery. , Surgeons can spray ... bio-polymer solutions in the gel will cohere and control ... The gel can shorten an intracranial surgery by 30- ... the patient,s skull to be open and less anesthesia, ...
(Date:7/10/2014)... today that Courtney Aldrich, Ph.D., will head the ... as editor-in-chief. With the first issue slated for ... meet a growing demand for a place to ... vision is to develop a journal focused on ... science that advances the field and lays the ...
(Date:7/10/2014)... with a cardiac pacemaker, a low sense of self-competence ... a study in the July Journal of ... of the Society for Developmental and Behavioral Pediatrics ... Williams & Wilkins , a part of Wolters ... protective factor against lower health-related quality of life in ...
Breaking Biology News(10 mins):A start-up at NJIT develops bleeding-control gel for brain surgery 2ACS Infectious Diseases: Unique chemistry journal names editor 2For children with pacemakers, 'self-competence' affects quality of life 2
... The next time you,re outdoors, see if you can spot the ... an easy task trees there are few and far between, ... In the temperate Northeast, dense forests make the exercise a bit ... sequoias often reach higher than the eye can estimate. Knowing ...
... The United States joined more than 50 countries Thursday ... to better track vessels engaged in illegal, unreported and ... highly migratory species. Annual global economic losses due to ... $23 billion. This action is a first step ...
... This release is available in French . ... Neanderthals and is found exclusively in people outside Africa, according ... of the Department of Pediatrics at the University of Montreal ... in the July issue of Molecular Biology and Evolution. ...
Cached Biology News:MIT: The tallest tree in the land 2MIT: The tallest tree in the land 3US joins over 50 nations in adopting recommendation to list vessels engaged in illegal fishing 2US joins over 50 nations in adopting recommendation to list vessels engaged in illegal fishing 3Genetic research confirms that non-Africans are part Neanderthal 2
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company ... under simulated embryonic conditions, today announced that they have ... Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent ... is an amendment to the existing license between Histogen ...
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, ... is an emerging biomedical company acquiring, developing, manufacturing, and ... , Free report download: http://equitiesiq.com/reports/alliqua/ , In ... team and Board, which launched the company’s new strategy ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Having judged last years a success, the ... opened the second annual Wisconsin Governor's Business Plan ... ,Interested businesses will submit 250-word business proposals within one ... and business services. The proposals will be accepted until ...
... open Thursday , Madison, Wis. The UW-Madison ... advances in nanotechnology, run by the university and Milwaukees ... December 16 during a campus open house, with parking in ... as the manufacture of tiny robots, has led to many ...
... Gateway Technical College has almost finished ... Advanced Career Education Program , and already it has gained ... its ideas. , ,The college receieved a grant on Tuesday ... part by the success of its partnership program. The funds ...
Cached Biology Technology:Governors business-plan competition starts another round 2Governors business-plan competition starts another round 3Tech Digest: Nanotechnology, GE Healthcare, NovaMed, PhysioGenix 2Gateway Technical College pilots IBM training program 2
... All MagCellect Ferrofluid products perform ... with R&D Systems MagCellect Magnet. ... this neodymium iron boron permanent ... x 75 mm test tubes ...
... 2'-O-Methyltransferase converts Cap 0 (or Cap 0-like) ... 1 structure has been shown to increase ... 50%. This improvement is seen in Cap ... Capping System as well as those Cap ...
Request Info...
Form: Ready to use Applications: Western Blot, ELISA...
Biology Products: