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New knowledge about the brain's effective bouncer
Date:7/15/2014

multidrug resistance-associated protein 1 are active in the artificially created barrier tissue. The proteins pump pharmacological agents from the 'brain side' to the 'blood side' in the same way as in the human blood-brain barrier.

Collaboration finds a way

The new findings have resulted from collaboration with industrial scientists from the pharmaceutical company H. Lundbeck A/S.

"It is important to the treatment of brain diseases such as Alzheimer's that we find a way of circumventing the brain's effective defence. The university and industry must work together to overcome the fundamental challenges inherent in developing pharmaceuticals for the future," says Lassina Badolo, Principal Scientist with H. Lundbeck A/S and an expert on the absorption of medicines in the body.

Associate Professor Birger Brodin adds:

"We have shown that the models have the same bouncer proteins as the ones found in the intact barrier. We are now in the process of studying the proteins in the blood-brain barrier that accept pharmacological agents instead of throwing them out. If we can combine a beneficial substance which the brain needs with a so-called 'absorber protein', we will in the long term be able to smuggle pharmacological agents across the blood-brain barrier."


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Contact: Birger Brodin
birger.brodin@sund.ku.dk
45-22-48-03-55
University of Copenhagen The Faculty of Health and Medical Sciences
Source:Eurekalert

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