Navigation Links
New knowledge about serious muscle disease
Date:10/31/2013

y to the functioning of the human organism, and genetic defects in the process that attaches mannose to the proteins known as O-mannosylation can lead to diseases such as muscular dystrophy.

"To date, only one single protein has been identified and characterised where the mannose deficiency on the protein leads to muscular dystrophy, but our method enables us to faster identify many new proteins that have mannose attached and therefore potentially play a key role for the disease," says Adnan Halim, who is associated with the research project and a postdoc with the Danish National Research Foundation, Copenhagen Center for Glycomics.

Facts about muscular dystrophy

Muscular dystrophy is a collective term for a range of neuromuscular disorders. There are roughly 100 different known muscular dystrophy diagnoses, which manifest themselves as various functional impairments/disabilities. The individual diagnoses vary greatly, as does the manner in which they develop. Some people experience only a few symptoms, while others suffer extensive functional impairment. About 3,000 people in Denmark suffer from one of the muscle-related diseases classified as muscular dystrophy. Muscular dystrophy cannot be cured, but much can be done to relieve and treat the consequences of the diseases. Source: The Danish Muscular Dystrophy Foundation.

Facts about the research

The researchers used cells with a functional pathway to attach mannose to proteins, but then simplified the proteins' sugar chains by removing the gene responsible for lengthening the chains and making them more complex. The proteins carrying the 'sugar chain', which now consists solely of mannose, were then isolated, enabling the researchers to determine which proteins carried mannose and where the mannose was situated.

Facts about mannose

For many years researchers believed that O-linked mannose on proteins was found only in yeast, bu
'/>"/>

Contact: Malene Bech Vester-Christensen
mbxc@novonordisk.com
45-22-15-25-89
University of Copenhagen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Knowledge about incontinence and pelvic organ prolapse lower among women of color
2. Reproductive biologists move in vitro fertilization knowledge forward
3. New framework to deliver biodiversity knowledge
4. New knowledge about permafrost improving climate models
5. Ag, big data, and traditional knowledge headline the Ecological Society of Americas 2013 Meeting
6. Paving the way for greater use of ancient medical knowledge
7. Disease knowledge may advance faster with CRISPR gene probing tool
8. Growing talent -- schools to provide vital knowledge for food security
9. US and French long-term ecological research networks agree to share knowledge and skills
10. Toward an European open biodiversity knowledge management system
11. Baiting mosquitoes with knowledge and proven insecticides
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... City of Entiat on Tuesday, July 8, 2014. Despite ... to over 1,000 acres by evening. Three outbuildings were ... by the Washington Department of Natural Resources. The ... developing fire control strategies and tactics. Other cooperators include ... Natural Resources, (WA DNR), Bureau of Land Management, Chelan ...
(Date:7/11/2014)... the National Institute of Standards and Technology (NIST) ... more effectively, they often prove that necessity is ... case recently for M. Lorna De Leoz and ... specialization of glycomics. Glycomics is the study of ... are attached to proteins and lipids and influence ...
(Date:7/11/2014)... have explored two different ways that allow unprecedented ... the formation of oxygen molecules in photosynthesis. The ... journal Nature Communications . , "The new ... for water oxidation, which are key components for ... of solar energy in fuels like hydrogen, ethanol ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... IODP Arctic Coring Expedition (ACEX) is making news with new ... Nature, an article by several of the expedition scientists summarizes ... unusually wet, and ice-free up to the time the last ... atmosphere ?a period calculated to have occurred 55 million years ...
... designated Special Areas of Conservation throughout the UK, including ... pile driving. The frequency range of pile driving noise ... and avoid predators. This has the potential to affect ... Lactating females and young calves might be particularly vulnerable ...
... studies offer new evidence suggesting an alternative form of natural ... the blood in humans at levels determined to protect against ... in eight different forms. The primary vitamin E on drugstore ... of vitamin E surfacing as a potent neuroprotective agent in ...
Cached Biology News:Arctic coring expedition continues to yield new clues 2Dolphins at risk 2Natural vitamin E tocotrienol reaches blood at protective levels 2Natural vitamin E tocotrienol reaches blood at protective levels 3
(Date:7/10/2014)... 10, 2014 Women in the ... to an additional family planning option. Sayana® Press ... at all levels of the health system and ... a widely used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with ... is the first of four African countries expected ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
(Date:7/10/2014)... 2014   Ceres, Inc . (Nasdaq: ... today financial results for the three months ended May ... Ceres reported that the company and its ... growing season in Brazil, which concluded in June, despite ... evaluation areas for part of the growing season. Yields ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... Submission demonstrates progress of plant-derived insulin program, ... -, TSX symbol: SBS, CALGARY, July ... company developing a portfolio of therapeutic,proteins for metabolic ... an Investigational New Drug (IND) application for,safflower-produced recombinant ...
... ArunA Biomedical, Inc., the first,company to commercialize human ... that William T. Sharp has been named President,and ... leadership,responsibilities, Mr. Sharp has also been appointed to ... Steven Stice, PhD, who will,remain ArunA,s Chairman and ...
... MADISON Though bacteria are everywhere from the air we ... the vast majority are innocuous or even beneficial, and only ... microbial guest from an unwanted intruder? , Research from the ... but with the host. , A study appearing online this week ...
Cached Biology Technology:SemBioSys submits IND for safflower-produced insulin to U.S. FDA 2SemBioSys submits IND for safflower-produced insulin to U.S. FDA 3ArunA Biomedical Names William T. Sharp President and Chief Executive Officer 2Symbiotic microbes induce profound genetic changes in their hosts 2
...
... Arrays can be used to test the ... and sera that are commonly used as ... contains spots for 21 different protein preparations ... antibody crossreactivity and species specificity, QC of ...
... DNA sequencing is the experimental process ... DNA region. The automated DNA Sequencing is ... thermostable DNA polymerase, which allows cycle sequencing ... and detected in a capillary instrument controlled ...
... On-Demand Cytometry The Guava ... blue laser based multiparameter cytometer with built-in ... you can screen plates of cells and ... of manipulating multiple tubes or having the ...
Biology Products: