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New key mechanism in cell division discovered
Date:5/18/2012

eralt described for the first time the involvement of Zds1 protein in mitosis. This protein cooperates with the separase to ensure correct genetic inheritance from cell to cell.

The study delves into the molecular mechanism by which this protein Zds1 regulates mitosis and contributes to the right segregation of chromosomes. In this paper there have been used the yeast Saccharomyces cerevisiae as a model organism.

Yeast is one of the most widely used model organisms to study basic processes in the cell, allowing to identify complex molecular mechanisms as the study of cell cycle in higher organisms. The application of such basic knowledge will help to develop more specific and direct treatments against various cancers.

Dr. Queralt points out that "the mechanisms of regulation of mitosis are very complex and well-known fact opens the door to specific drugs that inhibit or enable to correct this process in various diseases, especially cancer." She explains that most anticancer drugs are being implemented without knowing exactly how they work, "these are compounds that often we do not know how are working, but they do. If we follow a reverse process, ie if we start to know the activity of a protein or part of the protein, we could design specific drugs to minimize side effects." Dr. Queralt's researching is an important step in developing therapies that prevent tumour cells from replicating.


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Contact: Jordi Morato
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

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