Navigation Links
New key mechanism in cell division discovered
Date:5/18/2012

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have identified the mechanism by which protein Zds1 regulates a key function in mitosis, the process that occurs immediately before cell division. The result has been achieved in the online edition of the Journal of Cell Science and opens the door to developing targeted and direct therapies against cancer.

In every organism, cells grow and divide into two daughter cells through an orderly succession of events called "cell cycle". Cells have to complete four main processes during the cell cycle: growth (G1 and G2 phases), doubling the DNA (S phase), segregation of chromosomes (M phase, mitosis) and division (cytokinesis). In the S phase or DNA replication, the genetic material is duplicated and then during the M phase or mitosis, cells separate the duplicated chromosomes between two daughter cells. This will ensure correct inheritance of genetic information from one cell generation to the next.

Chromosomal stability

The transmission of genetic information (DNA) from parent to child (or equivalently, from cell to cell) is a fundamental question in biology. Aneuploidy, ie lack or excess of chromosomes, is a feature present in almost all human cancers and promotes tumour development. Regulation of mitosis is particularly important for maintaining chromosomal stability. For example, tumour cells are aneuploid due to defects in the segregation of chromosomes, which originate cells with more or less genetic material than usual.

However, in spite of its importance, very little is known about the output regulation of mitosis. In the article published in the Journal of Cell Science, the Cell Cycle research group at IDIBELL led by Ethel Queralt, discovers a new mechanism of regulation of mitotic exit.

Separase protein is a key component for proper chromosome segregation and the regulation of mitosis. In previous work, the group of Dr. Queralt described for the first time the involvement of Zds1 protein in mitosis. This protein cooperates with the separase to ensure correct genetic inheritance from cell to cell.

The study delves into the molecular mechanism by which this protein Zds1 regulates mitosis and contributes to the right segregation of chromosomes. In this paper there have been used the yeast Saccharomyces cerevisiae as a model organism.

Yeast is one of the most widely used model organisms to study basic processes in the cell, allowing to identify complex molecular mechanisms as the study of cell cycle in higher organisms. The application of such basic knowledge will help to develop more specific and direct treatments against various cancers.

Dr. Queralt points out that "the mechanisms of regulation of mitosis are very complex and well-known fact opens the door to specific drugs that inhibit or enable to correct this process in various diseases, especially cancer." She explains that most anticancer drugs are being implemented without knowing exactly how they work, "these are compounds that often we do not know how are working, but they do. If we follow a reverse process, ie if we start to know the activity of a protein or part of the protein, we could design specific drugs to minimize side effects." Dr. Queralt's researching is an important step in developing therapies that prevent tumour cells from replicating.


'/>"/>

Contact: Jordi Morato
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Researchers find mechanism that gives plants balance
2. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
3. Housekeeping mechanism for brain stem cells discovered
4. New genetic mechanism of immune deficiency discovered
5. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
6. Mechanism found connecting metastatic breast cancer and arthritis
7. Researchers unravel genetic mechanism of fatty liver disease in obese children
8. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
9. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
10. Mechanism for Burgess Shale-type preservation
11. Another mechanism discovered by which sulforaphane prevents cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... findings on what they believe could be a new and helpful biomarker for ... research. Click here to read it now. , Biomarkers are components ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of 8.5 ... end machines that use the more unconventional z-dimension of 20mm. Z-dimension or ... the cuvette holder. , FireflySci has developed several Agilent flow cell product lines ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
Breaking Biology Technology: